On February 26, 2023, the Board of Directors of Aptinyx, Inc. approved a restructuring plan (the “Plan”) to reduce the Company's operating costs and better align its workforce with the needs of its business. Under the Plan, the Company is reducing its workforce by approximately 60%, to be substantially completed by March 3, 2023. The Company expects to incur estimated severance and related costs of approximately $1.4 million, which will be recorded primarily in the first quarter of 2023.