On October 3, 2023, Christopher Brooke resigned as Chief Operating Officer of Aytu BioPharma, Inc. (the ?Company?), effective October 13, 2023, to pursue another opportunity at a development-stage biotechnology company. Mr. Brooke?s resignation is not due to any outstanding issues with the Company or disagreements with respect to the Company?s operations, policies or practices, or the Company?s independent auditors. The Company does not intend to seek a replacement for the position of Chief Operating Officer given the Company?s wind down of manufacturing operations at its Grand Prairie, TX production facility and indefinite suspension of all pipeline research and development programs.