Constellation Pharmaceuticals, Inc. announced the appointment of Adrian Senderowicz, M.D., as senior vice president and chief medical officer. In addition, the company is promoting three members of its management team, underscoring Constellation Pharmaceuticals’ strategic focus on charting a clear path to registration for the company’s two lead clinical development programs, CPI-1205 and CPI-0610—targeting EZH2 (a member of the PRC2 complex) and BET, respectively—while also exploring new opportunities at the nexus of cancer epigenetics and immuno-oncology. A board-certified medical oncologist by training, Dr. Senderowicz has more than two decades of experience in the life sciences. He was the principal investigator for a multitude of clinical trials in solid and hematological tumors and brings to Constellation Pharmaceuticals significant regulatory expertise as a former clinical team leader at the U.S. Food and Drug Administration’s Center for Drug Evaluation and Research Division of Drug Oncology Products. Prior to joining Constellation Pharmaceuticals, Dr. Senderowicz served as chief medical officer at Cerulean Pharma, where he helped secure fast-track designation for the company’s lead clinical development program in two indications. Previously, Dr. Senderowicz held roles of increasing responsibility at Ignyta, Inc., Sanofi Oncology, Tokai Pharmaceuticals and AstraZeneca plc. In addition to Dr. Senderowicz’s appointment, Constellation Pharmaceuticals is bolstering its efforts by aligning its management team with near- and long-term research and development priorities. As such, the company has promoted Patrick Trojer, Ph.D., to senior vice president of the EZH2 franchise and head of translational sciences; Robert Sims, Ph.D., to senior vice president of research; and Brenda Sousa to senior vice president of human resources and operations. Dr. Trojer and Sims, both founding scientists of Constellation Pharmaceuticals, will work with Dr. Senderowicz to advance its two ongoing clinical development programs and novel R&D programs. As the head of the EZH2 franchise, Dr. Trojer will also be responsible for integrating translational research, clinical development and pre-commercial activities across CPI-1205 and the company’s next-generation PRC2 medicines. Moreover, Dr. Sims will lead the company’s discovery work, specifically applying its research in cancer epigenetics to the highly complementary area of immuno-oncology. Ms. Sousa will continue to focus on talent acquisition and development, as well as operations to ensure the company is well positioned to achieve its goals.