e-therapeutics plc announced the addition of its RNAi platform as a therapeutic drug modality. The Company has recently filed a patent application related to the chemistry of novel GalNAc-conjugated siRNAs (short interfering RNA), an important element of its RNAi platform that enables specific hepatocyte targeting for liver gene silencing. In addition, a number of siRNA constructs have been designed with potentially beneficial safety and potency profiles and additional patent applications are expected to be filed shortly. The company believes that the new patent applications, combined with know-how, will provide a significant competitive advantage in RNAi. The new constructs will include features to minimise potential microRNA off-target effects, thermally destabilising regions of the siRNA for reduced toxicity and important position-specific stabilisation chemistries to improve potency. Multiple in vitro and in vivo experiments are underway to test these constructs with contract research organizations in Germany and China.