Enveric Biosciences, Inc. announced successful completion of preclinical ADME and toxicology studies conforming to earlier positive results from PK animal studies and supportive of Enveric's clinical design objectives for reduced overall side effects and shorter duration of hallucinatory effect for its lead candidate EB-373. The in vitro assays using liver extracts derived from human, dog, rat, and mouse models demonstrated efficient conversion of EB-373 to active metabolite psilocin, with consistent results across all species. Preclinical results for EB-373 have consistently shown rapid achievement of peak psilocin concentration in the blood at levels >95% that of the parent prodrug, indicating the almost complete conversion of EB-373 to psilocin by the liver.

The in vitro results align with prior results in animal studies that demonstrated faster onset of acute peak neuroactive effects.