On April 15, 2023, Dominic Perks notified the board of directors of Gelesis Holdings, Inc. that he is resigning from the Board as a Class I director, effective immediately. Mr. Perks' decision to resign from the Board was due to his other professional responsibilities and was not a result of any disagreement with the Company on any matter relating to the Company's operations, policies, or practices. Mr. Perks served on the Board at the request of Hambro Perks Asset Management Limited, a Guernsey limited company (“Hambro Perks”) and the manager of HPSO SPV Limited, a beneficial owner of more than 10% of the Company's outstanding shares of common stock as of March 24, 2023.

Mr. Perks resigned from his position with Hambro Perks concurrently with his resignation from the Board.