In connection with the Acquisition and as of the Effective Time, each of Timothy P. Walbert, Michael Grey,
William F. Daniel, Jeff Himawan, Ph.D., Susan Mahony, Ph.D., Gino Santini, James Shannon, M.D., H. Thomas Watkins and Pascale Witz ceased serving as a member of the board of directors of Horizon Therapeutics Public Limited Company and each committee thereof on which such director served.