Jasper Therapeutics, Inc. announced that positive final results from the Phase 1 study of briquilimab in combination with fludarabine and low-dose irradiation (Flu/TBI) conditioning in older adults with acute myeloid leukemia (AML) in complete remission or myelodysplastic syndromes (MDS) undergoing allogeneic hematopoietic cell transplant (HCT) will be presented during an oral session at the America Society of Hematology (ASH) 2023 Annual Meeting & Exposition, being held December 9-12, 2023, in San Diego, CA. The study being presented demonstrated that a regimen of briquilimab plus Flu/TBI leads to successful engraftment of donor blood stem cell without the associated short and long-term toxicities that accompany busulfan-based regimens commonly used in transplant of donor or gene-corrected cells. Based on its mechanism of action, briquilimab is known to potently synergize with radiation, leading to stem cell depletion without increasing off-target toxicity.

Details of the presentation are as follows: Abstract Title: Final Results from Phase 1 Study of Briquilimab, an Anti-CD117 Monoclonal Antibody, in Combination with Low Dose Irradiation and Fludarabine Conditioning, Shows Durable Remissions in Older Adults with Acute, Myeloid Leukemia in Complete Remission and Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Cell Transplantation, Publication Number: 470, Session Number/Title: 721. Allogeneic Transplantation: Conditioning Regimens, Engraftment and Acute Toxicities: Novel Conditioning Regimens for Myeloid Malignancies, Date /Time:Sunday, December 10, 2023; 9:30 a.m. ? 11:00 a.m. PST, Presenting Author: Dr. Arpita Gandhi, M.D., M.S., Assistant Professor of Medicine, Division of Hematology/Medical Oncology, Oregon Health & Science University School of Medicine.