SCOTTSDALE - Journey Medical Corporation (Nasdaq: DERM) ('Journey Medical'), a commercial-stage pharmaceutical company that primarily focuses on the selling and marketing of FDA-approved prescription pharmaceutical products for the treatment of dermatological conditions, today announced positive topline results from the two Phase 3 multicenter, randomized, double-blind, parallel-group, active-comparator and placebo-controlled clinical trials, Minocycline Versus Oracea in Rosacea-1 ('MVOR-1') and Minocycline Versus Oracea in Rosacea-2 ('MVOR-2'), evaluating Minocycline Hydrochloride Modified Release Capsules, 40 mg ('DFD-29') for the treatment of moderate-to-severe papulopustular rosacea in adults.

DFD-29 is being developed for the treatment of rosacea in collaboration with Dr. Reddy's Laboratories Ltd.

Subjects in the MVOR-1 and MVOR-2 Phase 3 clinical trials were randomized in a 3:3:2 ratio to treatment with DFD-29, Doxycycline Capsules, 40 mg ('Oracea') or placebo once daily for 16 weeks. The primary objective of both studies was to evaluate the safety and efficacy of DFD-29 compared to placebo for the treatment of papulopustular rosacea. The secondary objective was to evaluate the safety and efficacy of DFD-29 compared to Oracea. Both clinical trials achieved the co-primary and all secondary endpoints, which compared the efficacy of DFD-29 to Oracea and placebo for the treatment of rosacea. The proportion of subjects achieving Investigator's Global Assessment ('IGA') treatment success in the DFD-29 group was statistically superior to those in Oracea and placebo groups. Additionally, the reduction in the total inflammatory lesion count from baseline to week 16 in the DFD-29 group was statistically superior to Oracea and placebo groups. There were no major safety issues and no serious adverse events related to study products in both MVOR-1 and MVOR-2 trials. The number of treatment emergent adverse events ('TEAEs') and their severity were similar between the treatment groups. The number of TEAEs related to study products were also similar between the groups.

MVOR-1 Topline Results

In the DFD-29 group, 65.0% of subjects demonstrated IGA success, while 46.1% showed IGA success in the Oracea group and 31.2% of subjects showed IGA success in the placebo group. The difference between the DFD-29 and Oracea groups was statistically significant with a p-value of 0.007, and the difference between the DFD-29 and the placebo groups was statistically significant with a p-value of

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