Press release
09.00 EEST / 08.00 CEST
Nanoform and PlusVitech partner to repurpose aprepitant as a treatment for lung cancer
Following PlusVitech's positive first time in human studies, a Phase 2 study with 24 patients has commenced, investigating the efficacy of high dose aprepitant in a non-small cell lung cancer (NSCLC) population that is refractory to standard treatment. The current formulation carries a high pill burden of potentially dozens of capsules per day, with a complicated regimen for patients that are most often frail and have trouble swallowing (dysphagia). The new formulation by Nanoform is designed to deliver substantially higher drug load with better bioavailability, which simplifies the dose regimen and improves patient convenience and compliance. Repurposing an existing drug offers a potentially faster, risk-reduced and cost-effective development path to provide new treatments for high medical need indications like NSCLC.
"Our mission is to employ Nanoform's leading nanotechnology to provide patients with new treatments as fast as possible and we are excited to work with PlusVitech on this promising new approach to help lung cancer patients", said Edward Hæggström, CEO of Nanoform. "Following the recent positive results for nanoenzalutamide and nanoapalutamide, this is yet another example of the increasing number of oncology programs that our best-in-class nanomedicine approach empowers".
"Getting this medicine into a pivotal Phase 3 trial with a dose form that's suitable for these very ill patients is vital for the PlusVitech team of highly passionate professionals", said Dr.
Nanoform's nanocrystalline formulations enable significantly higher drug loading, allowing for smaller pills and a reduced pill burden. Its Controlled Expansion of Supercritical Solutions (CESS®) technology uses carbon dioxide of recycled origin, and is free from organic hydrocarbons and solvents, offering an environmentally sustainable alternative.
Nanoform's technology delivers some of the world's smallest nanoparticles, at clinical and commercial scale, for multiple pharmaceutical innovator partners for new product developments, 505(b)(2) pathway projects, and differentiated generics across oral, hydrogel, ophthalmic, inhaled and injectable dose forms. Nanoform's state of the art development and manufacturing facility is located adjacent to
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About Nanoform
Nanoform is the medicine performance-enhancing company that leverages best-in-class innovative nanoparticle engineering technologies, expert formulation, and scalable GMP API manufacturing to enable superior medicines for patients. The company focuses on reducing clinical attrition and on enhancing drug molecules' performance through its nanoforming technologies and formulation services, from pre-formulation to commercial scale. Nanoform will help improve bioavailability and drug delivery profiles, drive differentiation, patient adherence and extend the lifecycle potential of products. Nanoform's shares are listed on the Premier-segment of Nasdaq First North Growth Market in
About PlusVitech
PlusVitech is a Spanish biotechnology/pharmaceutical/medicine company, spin-off of the Andalusian Health Service. It was founded in 2013 in
Forward-Looking Statements
This press release contains forward-looking statements, including, without limitation, statements regarding Nanoform's strategy, business plans and focus. The words "may", "will", "could", "would", "should", "expect", "plan", "anticipate", "intend", believe", "estimate", "predict", "project", "potential", "continue", "target" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, any related to Nanoform's business, operations, clinical trials, supply chain, strategy, goals and anticipated timelines, competition from other companies, and other risks described in the Report of the Board of Directors and Financial Statements for the year ended
https://news.cision.com/nanoform/r/nanoform-and-plusvitech-partner-to-repurpose-aprepitant-as-a-treatment-for-lung-cancer,c3958300
https://mb.cision.com/Main/18905/3958300/2718352.pdf
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