Nyxoah SA announced data from a real-world case series evaluating treatment of three complete concentric collapse (CCC) patients with the Genio(R) hypoglossal nerve stimulation system. The investigator-sponsored case series was presented by Dr. Christian Plettenberg from the Universittsklinikum Dseldorf on December 8, 2023. Results showed an average apnea-hypopnea index (AHI) decrease of 73% and Epworth Sleepiness Scale (ESS) decrease of 58%.

There were no implant related adverse events. Key Results: AHI: The AHI in Patient 1 decreased from 44/h to 5.6/h, in Patient 2 from 24/h to1.2/h and in Patient 3 from 3636/h to 11.2/h. This resulted in an average reduction of 73%. ESS: The ESS in Patient 1 decreased from 15 to 2, in Patient 2 from 12 to 9 and in Patient 3 from 11 to 5. This resulted in an average reduce of 58%.