On June 25, 2019, Hong Fang Simone Song, a Class I Director of the Company, stepped down from the Orchard Therapeutics plc's Board of Directors effective immediately prior to the Annual General Meeting on June 26, 2019 and at the completion of her term. Ms. Song's decision to resign was not the result of any disagreement with the Company on any matter relating to the Company's operations, policies or practices.