ProQR Therapeutics N.V. has appointed René Beukema as a member of the management team in the role of Chief Corporate Development Officer and General Counsel. Mr. Beukema is also nominated to join the Management Board, subject to approval by shareholders at the AGM. Mr. Beukema is a seasoned M&A and equity capital markets executive and an experienced corporate lawyer who previously served as the Company's Chief Corporate Development Officer and General Counsel from September 2013 to December 2018.

Most recently, he has been General Counsel & Chief Corporate Development at Frame Cancer Therapeutics. Prior to his initial tenure at the Company, Mr. Beukema served as General Counsel and Corporate Secretary of Crucell N.V. for twelve years, following his positions as Senior Legal Counsel at GE Capital /TIP Europe and Legal Counsel at TNT Express Worldwide. Mr. Beukema was also a venture partner of Aescap Venture, a life sciences venture capital firm from 2011 to 2012 and is co-founder and advisor of Mytomorrows N.V., a Dutch life sciences company.

He holds a post-doctoral degree in corporate law from the University of Nijmegen in co-operation with the Dutch Association of In-house Counsel (Nederlands Genootschap van Bedrijfsjuristen) and a master's degree in Dutch law from the University of Amsterdam. Gerard Platenburg has assumed the role of Chief Scientific Officer, where he will continue to provide strategic oversight of ProQR's proprietary Axiomer RNA-editing platform technology. He is the scientific co-founder of ProQR and previously served as ProQR's Chief Innovation Officer from 2014 to 2022.

John Maraganore, PhD, a biopharma industry leader and the former founding CEO of Alnylam Pharmaceuticals, will extend his commitment as a strategic advisor to the Supervisory Board. Dr. Maraganore previously joined the Company in March 2022 as a strategic advisor to help it define an updated strategic focus. Going forward, Dr. Maraganore will join all Supervisory Board meetings to guide the Company in rolling out the new strategy, including further building out the Company's Axiomer RNA-editing technology as a value-generating platform.

Smital Shah, Chief Business and Financial Officer, will be leaving the Company and a search has been initiated for a Chief Financial Officer. As part of the planned transition, Ms. Shah will depart ProQR at the end of 2022.