Valuation: Silence Therapeutics plc

Market Cap 448M 592M 528M 492M 842M 57.3B 851M 5.9B 2.3B 29.22B 2.22B 2.18B 93.49B P/E 2026 *
-18.5x
P/E 2027 * -14.8x
Enterprise Value 315M 416M 371M 346M 592M 40.27B 598M 4.15B 1.61B 20.54B 1.56B 1.53B 65.69B EV / Sales 2026 *
976x
EV / Sales 2027 * 365x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Chief Executive Officer 72 2025-11-30
Director of Finance/CFO 54 2022-01-31
Chief Tech/Sci/R&D Officer - 2020-12-31
Director TitleAgeSince
Director/Board Member 63 2018-06-20
Chairman 72 2003-12-31
Director/Board Member 65 2025-05-04
Change 5-day change 1-year change 3-year change Capi.($)
-3.19%-3.19%+44.60%+87.98% 74.68B
-15.86%-16.67%+3.92%+50.90% 58.7B
-2.39%-2.05%+4.29%+31.33% 48.36B
-6.35%-8.35%+303.95%+651.28% 43.05B
+0.30%-3.71%+28.89%+30.33% 42.48B
-3.82%-4.32%+2.49%+101.36% 41.39B
-2.13%+1.07%+7.51%+50.31% 31.29B
-3.35%-6.35%-13.20%-17.22% 23.93B
-1.24%-11.97%-38.10%+311.13% 22.22B
Average -4.23%-2.63%+38.26%+144.16% 42.9B
Weighted average by Cap. -4.86%-1.88%+44.70%+136.42%

Financials

2026 *2027 *
Net sales 322K 427K 380K 355K 607K 41.27M 613K 4.25M 1.65M 21.05M 1.6M 1.57M 67.33M 751K 993K 885K 825K 1.41M 96.07M 1.43M 9.9M 3.85M 48.99M 3.72M 3.65M 157M
Net income -42.14M -55.74M -49.7M -46.34M -79.28M -5.39B -80.11M -556M -216M -2.75B -209M -205M -8.8B -71.01M -93.93M -83.76M -78.1M -134M -9.09B -135M -937M -364M -4.64B -352M -345M -14.83B
Net Debt -133M -176M -157M -146M -250M -17.04B -253M -1.76B -682M -8.69B -660M -647M -27.79B -174M -230M -205M -191M -327M -22.28B -331M -2.3B -892M -11.36B -863M -846M -36.34B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
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ESG MSCI
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Ratings Surperformance© - Silence Therapeutics plc