Tissue Regenix : Notice of AGM - 2023

Unit 3, Phoenix Court

Lotherton Way

Garforth, Leeds, England

LS25 2GY

Tel [phone]

www.tissueregenix.com

21 March 2023

Dear Shareholder

ANNUAL REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2022 ('ACCOUNTS') AND NOTICE OF 2023 ANNUAL GENERAL MEETING ('AGM')

Please accept this letter as notification that the Accounts of Tissue Regenix Group plc (the 'Company'), which include the notice of the 2023 AGM, have now been published. This document is available on the Company's website at www.tissueregenix.com.

AGM procedure

The Company's AGM will be held at DLA Piper, 160 Aldersgate St, Barbican, London EC1A 4HT, on 27 April 2023 at 11.00 a.m. Shareholders are invited to ask the Board questions about the Accounts or the AGM by email emailing Walbrook PR at [e-mail].

This letter does not contain the full details of the AGM resolutions, including the special resolutions for 2023. These are contained in the notice of the meeting and should be read before you submit your proxy votes. The Directors consider that the proposed resolutions contained in the notice of AGM are in the best interests of the Company and shareholders as a whole, and unanimously recommend that you vote in favour of them, as they intend to do in respect of their own shareholdings.

Proxy voting

You will not receive a hard copy form of proxy for the 2023 AGM in the post. Instead, you will be able to vote electronically using the link www.signalshares.com. You will need to log into your Signal Shares account or register if you have not previously done so. To register you will need your investor code, this is detailed on your share certificate or available from our registrar, Link Group (whose contact details are below).

If you are a CREST member, you can appoint a proxy electronically by using the CREST voting service.

If you are an institutional investor you may also be able to appoint a proxy electronically via the Proxymity platform, a process which has been agreed by the Company and approved by the Registrar. For further information regarding Proxymity, please go to www.proxymity.io. Your proxy must be lodged by 11.00 a.m. on 25 April 2023 in order to be considered valid or, if the meeting is adjourned, by the time which is 48 hours before the time of the adjourned meeting. Before you can appoint a proxy via this process you will need to have agreed to Proxymity's associated terms and conditions. It is important that you read these carefully as you will be bound by them and they will govern the electronic appointment of your proxy. An electronic proxy appointment via the Proxymity platform may be revoked completely by sending an authenticated message via the platform instructing the removal of your proxy vote.

If you would like to use a hard copy form of proxy, you can contact our Registrar, Link Group, and ask them to post you a proxy form. You will need to complete, sign and return your proxy form if you would rather do this than vote electronically.

Please follow the guidance in the notice of AGM concerning voting by proxy. Please note that proxy votes must be received no later than 11.00 a.m. GMT on Tuesday 25 April 2023.

If you need help with voting online, please contact our Registrar, Link Group, at [e-mail] by calling them on 0371 664 0300 if calling from the UK, or [phone] if calling from outside of the UK. Calls are charged at the standard geographic rate and will vary by provider. Calls outside the UK will be charged at the applicable international rate. The lines are open between 09.00 - 17.30, Monday to Friday excluding public holidays in England and Wales.

Thank you for your continued support as a shareholder of Tissue Regenix Group plc.

Yours sincerely,

Kirsten Lund

Company Secretary

Registered in England and Wales No. 05969271 Registered office as above

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