LONDON--(BUSINESS WIRE)--

FORM 8.3 - AMENDMENT TO SALES

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Full name of discloser:

Barclays PLC.

(b) Owner or controller of interests and short positions disclosed, if different from 1(a):

The naming of nominee or vehicle companies is insufficient. For a trust, the trustee(s), settlor and beneficiaries must be named.

(c) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

SHIRE PLC

(d) If an exempt fund manager connected with an offeror/offeree, state this and specify identity of offeror/offeree:
(e) Date position held/dealing undertaken:

For an opening position disclosure, state the latest practicable date prior to the disclosure

16 October 2018

(f) In addition to the company in 1(c) above, is the discloser making disclosures in respect of any other party to the offer?

If it is a cash offer or possible cash offer, state 'N/A'

YES TAKEDA PHARMACEUTICAL CO LTD

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security: 5p ordinary
Interests Short Positions
Number (%) Number (%)
(1) Relevant securities owned
and/or controlled: 4,462,556 0.49% 2,843,362 0.31%
(2) Cash-settled derivatives:
333,301 0.04% 3,454,452 0.38%
(3) Stock-settled derivatives (including options)
and agreements to purchase/sell: 254,300 0.03% 349,300 0.04%
(4)
TOTAL: 5,050,157 0.55% 6,647,114 0.73%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including traded options), or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other employee options)

Class of relevant security in relation to which subscription right exists:
Details, including nature of the rights concerned and relevant percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant Purchase/sale Number of Price per unit
security securities
5p ordinary Purchase 33 44.0150 GBP
5p ordinary Purchase 38 44.0300 GBP
5p ordinary Purchase 54 43.9600 GBP
5p ordinary Purchase 66 44.0000 GBP
5p ordinary Purchase 73 43.9350 GBP
5p ordinary Purchase 79 43.9950 GBP
5p ordinary Purchase 98 43.9885 GBP
5p ordinary Purchase 107 44.0100 GBP
5p ordinary Purchase 110 43.9725 GBP
5p ordinary Purchase 131 44.0050 GBP
5p ordinary Purchase 141 44.0200 GBP
5p ordinary Purchase 150 43.9900 GBP
5p ordinary Purchase 155 44.1396 GBP
5p ordinary Purchase 236 44.1689 GBP
5p ordinary Purchase 237 44.1000 GBP
5p ordinary Purchase 284 44.0831 GBP
5p ordinary Purchase 289 44.2010 GBP
5p ordinary Purchase 374 44.1700 GBP
5p ordinary Purchase 523 44.0689 GBP
5p ordinary Purchase 581 44.1414 GBP
5p ordinary Purchase 591 44.0104 GBP
5p ordinary Purchase 911 44.1691 GBP
5p ordinary Purchase 1,034 43.9978 GBP
5p ordinary Purchase 1,157 44.1697 GBP
5p ordinary Purchase 1,244 44.1207 GBP
5p ordinary Purchase 1,322 44.1683 GBP
5p ordinary Purchase 1,525 44.1798 GBP
5p ordinary Purchase 3,437 44.2076 GBP
5p ordinary Purchase 4,188 44.0651 GBP
5p ordinary Purchase 4,782 44.0630 GBP
5p ordinary Purchase 5,507 44.0458 GBP
5p ordinary Purchase 6,351 44.0951 GBP
5p ordinary Purchase 7,351 44.0899 GBP
5p ordinary Purchase 7,385 44.0619 GBP
5p ordinary Purchase 24,750 44.0785 GBP
5p ordinary Purchase 37,056 44.0650 GBP
5p ordinary Purchase 111,013 44.0826 GBP
5p ordinary Sale 28 43.9986 GBP
5p ordinary Sale 33 44.0150 GBP
5p ordinary Sale 38 44.0300 GBP
5p ordinary Sale 54 43.9600 GBP
5p ordinary Sale 66 44.0000 GBP
5p ordinary Sale 73 43.9350 GBP
5p ordinary Sale 79 43.9950 GBP
5p ordinary Sale 107 44.0100 GBP
5p ordinary Sale 131 44.0050 GBP
5p ordinary Sale 141 44.0200 GBP
5p ordinary Sale 150 43.9900 GBP
5p ordinary Sale 205 43.9822 GBP
5p ordinary Sale 241 44.0783 GBP
5p ordinary Sale 330 44.2212 GBP
5p ordinary Sale 466 44.1253 GBP
5p ordinary Sale 498 44.1205 GBP
5p ordinary Sale 591 44.0104 GBP
5p ordinary Sale 667 44.0383 GBP
5p ordinary Sale 705 43.9987 GBP
5p ordinary Sale 752 44.0487 GBP
5p ordinary Sale 864 44.1267 GBP
5p ordinary Sale 881 44.1994 GBP
5p ordinary Sale 986 44.2050 GBP
5p ordinary Sale 1,034 43.9978 GBP
5p ordinary Sale 3,071 43.9994 GBP
5p ordinary Sale 4,201 44.0550 GBP
5p ordinary Sale 4,236 44.1963 GBP
5p ordinary Sale 13,684 44.0384 GBP
5p ordinary Sale 15,102 44.0663 GBP
5p ordinary Sale 18,356 44.0687 GBP
5p ordinary Sale 22,804 44.0744 GBP
5p ordinary Sale 24,228 44.0650 GBP
5p ordinary Sale 108,032 44.0518 GBP
ADR Purchase 50 174.2599 USD
ADR Purchase 100 175.1100 USD
ADR Purchase 100 175.6500 USD
ADR Purchase 100 174.2900 USD
ADR Purchase 100 175.0800 USD
ADR Purchase 100 175.3300 USD
ADR Purchase 100 174.6000 USD
ADR Purchase 200 175.2300 USD
ADR Purchase 200 175.3100 USD
ADR Purchase 200 175.3350 USD
ADR Purchase 500 174.9665 USD
ADR Purchase 500 174.3165 USD
ADR Purchase 500 175.4380 USD
ADR Purchase 519 175.1413 USD
ADR Purchase 530 175.1339 USD
ADR Purchase 600 174.2975 USD
ADR Purchase 666 175.1325 USD
ADR Purchase 758 175.0827 USD
ADR Purchase 1,178 175.5100 USD
ADR Purchase 1,600 175.2112 USD
ADR Purchase 2,005 175.0846 USD
ADR Purchase 3,258 175.0524 USD
ADR Purchase 5,239 175.4214 USD
ADR Purchase 5,400 175.1447 USD
ADR Purchase 5,639 175.3945 USD
ADR Purchase 6,439 175.1529 USD
ADR Purchase 7,000 174.4000 USD
ADR Purchase 7,000 174.5515 USD
ADR Purchase 11,200 175.1006 USD
ADR Purchase 36,579 174.9777 USD
ADR Sale 20 175.1300 USD
ADR Sale 100 174.5200 USD
ADR Sale 100 174.2875 USD
ADR Sale 100 175.6900 USD
ADR Sale 100 175.7400 USD
ADR Sale 200 175.2200 USD
ADR Sale 200 175.4350 USD
ADR Sale 272 175.0955 USD
ADR Sale 300 175.3933 USD
ADR Sale 374 175.3032 USD
ADR Sale 400 174.3237 USD
ADR Sale 400 175.4200 USD
ADR Sale 400 175.0420 USD
ADR Sale 400 175.4300 USD
ADR Sale 500 175.4160 USD
ADR Sale 500 175.4380 USD
ADR Sale 578 175.3901 USD
ADR Sale 900 175.0288 USD
ADR Sale 1,100 175.4245 USD
ADR Sale 1,128 175.5100 USD
ADR Sale 1,244 175.0128 USD
ADR Sale 1,400 175.0792 USD
ADR Sale 1,561 175.4235 USD
ADR Sale 1,600 175.3632 USD
ADR Sale 1,770 175.1107 USD
ADR Sale 2,186 175.0615 USD
ADR Sale 3,481 175.1942 USD
ADR Sale 3,757 175.1657 USD
ADR Sale 3,800 174.9989 USD
ADR Sale 3,900 175.1164 USD
ADR Sale 4,100 175.1540 USD
ADR Sale 5,700 175.0160 USD
ADR Sale 6,429 175.0808 USD
ADR Sale 7,000 174.4000 USD
ADR Sale 7,600 175.0939 USD
ADR Sale 12,239 174.9238 USD
ADR Sale 15,671 175.1246 USD
ADR Sale 16,500 174.6500 USD
(b) Cash-settled derivative transactions
Class of Product Nature of dealing Number of Price per
relevant description reference unit
security securities
5p ordinary CFD Long 26 44.0384 GBP
5p ordinary CFD Long 342 44.2640 GBP
5p ordinary CFD Long 641 44.0383 GBP
5p ordinary CFD Long 3,071 43.9994 GBP
5p ordinary CFD Long 5,100 44.0209 GBP
5p ordinary SWAP Long 19,935 44.0070 GBP
5p ordinary SWAP Long 20,556 44.0558 GBP
5p ordinary SWAP Long 26,486 44.0650 GBP
5p ordinary SWAP Long 60,158 44.0584 GBP
5p ordinary SWAP Short 66 44.0000 GBP
5p ordinary CFD Short 289 44.2010 GBP
5p ordinary SWAP Short 372 44.0002 GBP
5p ordinary CFD Short 523 44.0689 GBP
5p ordinary CFD Short 1,525 44.1798 GBP
5p ordinary SWAP Short 2,978 44.1201 GBP
5p ordinary CFD Short 3,437 44.2076 GBP
5p ordinary CFD Short 7,351 44.0898 GBP
5p ordinary CFD Short 10,777 44.0685 GBP
5p ordinary SWAP Short 10,777 44.0685 GBP
5p ordinary CFD Short 22,214 44.1729 GBP
5p ordinary SWAP Short 26,177 44.0650 GBP
5p ordinary SWAP Short 63,093 44.0595 GBP

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class Product Writing, Number Exercise Type Expiry Option
of description purchasing, of price date money
relevant selling, securities per unit paid/
security varying etc to which received
option per unit
relates
ADR Call Options Selling 100 175 USD American 21 Dec 2018 7.8000 USD
ADR Put Options Selling 600 150 USD American 18 Apr 2019 5.2500 USD
ADR Put Options Selling 4,400 155 USD American 18 Apr 2019 6.4045 USD
ADR Put Options Selling 100 160 USD American 18 Apr 2019 7.7000 USD
ADR Put Options Selling 1,000 160 USD American 19 Jul 2019 8.5000 USD

(ii) Exercise

Class of relevant security Product description

e.g. call option

Exercising/ exercised against Number of securities Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security Nature of dealing

e.g. subscription, conversion

Details Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

18 Oct 2018

Contact name:

Large Holdings Regulatory Operations

Telephone number:

020 3134 7213

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel at monitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk.

143221.01

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN STOCK-SETTLED DERIVATIVE (INCLUDING OPTION) POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the 'Code')

1. KEY INFORMATION

Full name of person making disclosure:

Barclays PLC.

Name of offeror/offeree in relation to whose relevant securities the disclosure relates:

SHIRE PLC

2. STOCK-SETTLED DERIVATIVES (INCLUDING OPTIONS)

Class Product Writing, Number Exercise Type Expiry
of description purchasing, of price date
relevant selling, securities per unit
security varying etc to which
option
relates
5p ordinary Call Options Written -125,000 3600.0000 American 21 Dec 2018
5p ordinary Put Options Written 125,000 3600.0000 American 21 Dec 2018
ADR Call Options Purchased 100 140.0000 American 18 Jan 2019
ADR Call Options Purchased 100 105.0000 American 18 Jan 2019
ADR Call Options Purchased 100 160.0000 American 19 Oct 2018
ADR Call Options Purchased 100 220.0000 American 18 Jan 2019
ADR Call Options Purchased 100 180.0000 American 26 Oct 2018
ADR Call Options Purchased 100 110.0000 American 17 Jan 2020
ADR Call Options Purchased 200 130.0000 American 17 Jan 2020
ADR Call Options Purchased 200 160.0000 American 17 Jan 2020
ADR Call Options Purchased 200 190.0000 American 18 Jan 2019
ADR Call Options Purchased 200 120.0000 American 17 Jan 2020
ADR Call Options Purchased 200 135.0000 American 17 Jan 2020
ADR Call Options Purchased 200 155.0000 American 17 Jan 2020
ADR Call Options Purchased 200 210.0000 American 18 Jan 2019
ADR Call Options Purchased 300 115.0000 American 18 Jan 2019
ADR Call Options Purchased 300 175.0000 American 18 Jan 2019
ADR Call Options Purchased 400 230.0000 American 18 Jan 2019
ADR Call Options Purchased 500 165.0000 American 18 Jan 2019
ADR Call Options Purchased 500 150.0000 American 18 Jan 2019
ADR Call Options Purchased 500 125.0000 American 18 Jan 2019
ADR Call Options Purchased 1,000 180.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 135.0000 American 18 Jan 2019
ADR Call Options Purchased 1,000 170.0000 American 17 Jan 2020
ADR Call Options Purchased 1,200 170.0000 American 18 Jan 2019
ADR Call Options Purchased 1,200 165.0000 American 19 Oct 2018
ADR Call Options Purchased 1,700 195.0000 American 17 Jan 2020
ADR Call Options Purchased 2,000 150.0000 American 17 Jan 2020
ADR Call Options Purchased 2,200 195.0000 American 18 Jan 2019
ADR Call Options Purchased 2,400 170.0000 American 19 Oct 2018
ADR Call Options Purchased 3,100 155.0000 American 18 Jan 2019
ADR Call Options Purchased 3,500 125.0000 American 19 Oct 2018
ADR Call Options Purchased 3,700 185.0000 American 19 Oct 2018
ADR Call Options Purchased 3,900 190.0000 American 18 Apr 2019
ADR Call Options Purchased 5,000 195.0000 American 19 Oct 2018
ADR Call Options Purchased 21,700 200.0000 American 18 Jan 2019
ADR Call Options Written -56,000 200.0000 American 17 Jan 2020
ADR Call Options Written -18,400 185.0000 American 18 Jan 2019
ADR Call Options Written -15,300 180.0000 American 18 Jan 2019
ADR Call Options Written -4,100 180.0000 American 19 Oct 2018
ADR Call Options Written -3,000 130.0000 American 19 Oct 2018
ADR Call Options Written -2,700 145.0000 American 18 Jan 2019
ADR Call Options Written -1,100 210.0000 American 19 Oct 2018
ADR Call Options Written -1,000 85.0000 American 18 Jan 2019
ADR Call Options Written -900 175.0000 American 19 Oct 2018
ADR Call Options Written -800 155.0000 American 18 Apr 2019
ADR Call Options Written -800 160.0000 American 19 Oct 2018
ADR Call Options Written -500 160.0000 American 18 Apr 2019
ADR Call Options Written -500 135.0000 American 19 Jul 2019
ADR Call Options Written -100 130.0000 American 18 Jan 2019
ADR Call Options Written -100 140.0000 American 17 Jan 2020
ADR Call Options Written -100 145.0000 American 19 Oct 2018
ADR Call Options Written -100 175.0000 American 21 Dec 2018
ADR Call Options Written -100 150.0000 American 18 Apr 2019
ADR Call Options Written -100 170.0000 American 18 Apr 2019
ADR Put Options Purchased -45,400 175.0000 American 19 Oct 2018
ADR Put Options Purchased -18,800 135.0000 American 18 Jan 2019
ADR Put Options Purchased -8,600 170.0000 American 19 Oct 2018
ADR Put Options Purchased -6,700 165.0000 American 19 Oct 2018
ADR Put Options Purchased -5,900 180.0000 American 18 Jan 2019
ADR Put Options Purchased -4,600 155.0000 American 18 Jan 2019
ADR Put Options Purchased -3,700 145.0000 American 17 Jan 2020
ADR Put Options Purchased -3,000 155.0000 American 16 Nov 2018
ADR Put Options Purchased -2,700 80.0000 American 18 Jan 2019
ADR Put Options Purchased -2,500 120.0000 American 17 Jan 2020
ADR Put Options Purchased -2,300 85.0000 American 18 Jan 2019
ADR Put Options Purchased -1,800 115.0000 American 18 Jan 2019
ADR Put Options Purchased -1,500 165.0000 American 18 Jan 2019
ADR Put Options Purchased -1,200 135.0000 American 17 Jan 2020
ADR Put Options Purchased -1,100 150.0000 American 19 Oct 2018
ADR Put Options Purchased -1,000 140.0000 American 18 Jan 2019
ADR Put Options Purchased -1,000 170.0000 American 17 Jan 2020
ADR Put Options Purchased -1,000 150.0000 American 18 Jan 2019
ADR Put Options Purchased -1,000 105.0000 American 18 Jan 2019
ADR Put Options Purchased -1,000 80.0000 American 17 Jan 2020
ADR Put Options Purchased -800 150.0000 American 17 Jan 2020
ADR Put Options Purchased -700 160.0000 American 17 Jan 2020
ADR Put Options Purchased -500 175.0000 American 16 Nov 2018
ADR Put Options Purchased -500 140.0000 American 17 Jan 2020
ADR Put Options Purchased -400 165.0000 American 17 Jan 2020
ADR Put Options Purchased -400 145.0000 American 18 Jan 2019
ADR Put Options Purchased -200 115.0000 American 19 Oct 2018
ADR Put Options Purchased -200 170.0000 American 18 Jan 2019
ADR Put Options Purchased -100 155.0000 American 26 Oct 2018
ADR Put Options Written 100 110.0000 American 17 Jan 2020
ADR Put Options Written 100 168.0000 American 26 Oct 2018
ADR Put Options Written 100 95.0000 American 18 Jan 2019
ADR Put Options Written 100 160.0000 American 18 Apr 2019
ADR Put Options Written 100 110.0000 American 18 Jan 2019
ADR Put Options Written 100 75.0000 American 19 Oct 2018
ADR Put Options Written 100 140.0000 American 19 Oct 2018
ADR Put Options Written 200 100.0000 American 18 Jan 2019
ADR Put Options Written 200 200.0000 American 17 Jan 2020
ADR Put Options Written 200 70.0000 American 19 Oct 2018
ADR Put Options Written 200 125.0000 American 19 Oct 2018
ADR Put Options Written 500 125.0000 American 18 Jan 2019
ADR Put Options Written 800 150.0000 American 18 Apr 2019
ADR Put Options Written 1,000 90.0000 American 18 Jan 2019
ADR Put Options Written 2,300 130.0000 American 18 Jan 2019
ADR Put Options Written 5,300 120.0000 American 18 Jan 2019
ADR Put Options Written 5,500 145.0000 American 19 Oct 2018
ADR Put Options Written 7,200 155.0000 American 18 Apr 2019
ADR Put Options Written 7,800 160.0000 American 18 Jan 2019
ADR Put Options Written 9,000 170.0000 American 18 Apr 2019
ADR Put Options Written 11,000 160.0000 American 19 Jul 2019
ADR Put Options Written 18,300 155.0000 American 0 Jan 1900

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to cash-settled derivatives.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

View source version on businesswire.com:https://www.businesswire.com/news/home/20181018005575/en/

BARCLAYS PLC

Source: BARCLAYS PLC

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Barclays plc published this content on 18 October 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 18 October 2018 14:52:05 UTC