LONDON--(BUSINESS WIRE)--

FORM 8.3 Amendment to Purchase

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Full name of discloser: Barclays PLC.
(b) Owner or controller of interest and short
positions disclosed, if different from 1(a):
(c) Name of offeror/offeree in relation to whose SHIRE PLC
relevant securities this form relates:
(d) If an exempt fund manager connected with an
offeror/offeree, state this and specify identity of
offeror/offeree:
(e) Date position held/dealing undertaken: 27 December 2018
(f) In addition to the company in 1(c) above, is the discloser making YES:
disclosures in respect of any other party to the offer? TAKEDA PHARMACEUTICAL CO LTD

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security: 5p ordinary
Interests Short Positions
Number (%) Number (%)
(1) Relevant securities owned
and/or controlled: 7,268,635 0.79% 786,321 0.09%
(2) Cash-settled derivatives:
317,685 0.03% 5,455,013 0.59%
(3) Stock-settled derivatives (including options)
and agreements to purchase/sell: 751,500 0.08% 560,800 0.06%
(4)
TOTAL: 8,337,820 0.91% 6,802,134 0.74%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including traded options), or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other employee options)

Class of relevant security in relation to which subscription right exists:
Details, including nature of the rights concerned and relevant percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant Purchase/sale Number of Price per unit
security securities
5p ordinary Purchase 21 45.7500 GBP
5p ordinary Purchase 1,385 45.9000 GBP
5p ordinary Purchase 110 45.3056 GBP
5p ordinary Purchase 15,000 45.7000 GBP
5p ordinary Purchase 26,217 45.6954 GBP
5p ordinary Purchase 41,500 45.5000 GBP
5p ordinary Purchase 64,240 45.3000 GBP
5p ordinary Purchase 135,634 45.3600 GBP
5p ordinary Purchase 164,046 45.4000 GBP
5p ordinary Sale 1,629 44.0000 GBP
5p ordinary Sale 6,000 45.4333 GBP
5p ordinary Sale 26,217 45.7000 GBP
5p ordinary Sale 29,334 45.3600 GBP
5p ordinary Sale 32,235 44.9456 GBP
5p ordinary Sale 61,667 45.1000 GBP
5p ordinary Sale 35,000 45.5546 GBP
5p ordinary Sale 225,000 44.9130 GBP
5p ordinary Sale 620,065 45.4311 GBP
ADR Purchase 8 173.8100 USD
ADR Purchase 22 173.2200 USD
ADR Purchase 68 172.9202 USD
ADR Purchase 98 172.6000 USD
ADR Purchase 100 173.7500 USD
ADR Purchase 100 172.7700 USD
ADR Purchase 100 171.5700 USD
ADR Purchase 100 172.9000 USD
ADR Purchase 200 172.7100 USD
ADR Purchase 200 174.0000 USD
ADR Purchase 261 173.4559 USD
ADR Purchase 400 172.1187 USD
ADR Purchase 434 172.2411 USD
ADR Purchase 566 172.2500 USD
ADR Purchase 700 172.1028 USD
ADR Purchase 700 172.3850 USD
ADR Purchase 800 173.8437 USD
ADR Purchase 880 172.9823 USD
ADR Purchase 1,000 172.2920 USD
ADR Purchase 1,000 173.8750 USD
ADR Purchase 1,000 172.6149 USD
ADR Purchase 1,051 172.6058 USD
ADR Purchase 1,134 172.8000 USD
ADR Purchase 1,173 171.8841 USD
ADR Purchase 3,201 173.9800 USD
ADR Sale 8 173.8100 USD
ADR Sale 28 172.3100 USD
ADR Sale 33 172.0100 USD
ADR Sale 76 173.8500 USD
ADR Sale 100 172.0400 USD
ADR Sale 100 172.9000 USD
ADR Sale 100 171.5700 USD
ADR Sale 200 173.8550 USD
ADR Sale 300 171.9083 USD
ADR Sale 398 172.2904 USD
ADR Sale 775 171.6754 USD
ADR Sale 790 172.2043 USD
ADR Sale 800 172.4306 USD
ADR Sale 1,000 172.2462 USD
ADR Sale 1,100 172.2263 USD
ADR Sale 2,000 173.8750 USD
ADR Sale 3,063 172.8041 USD
ADR Sale 6,895 173.9800 USD

(b) Cash-settled derivative transactions

Class of Product Nature of dealing Number of Price per
relevant description reference unit
security securities
5p ordinary SWAP Long 4,616 44.7118 GBP
5p ordinary SWAP Long 58,680 45.0979 GBP
5p ordinary SWAP Short 1 45.7600 GBP
5p ordinary SWAP Short 20 45.7500 GBP

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class Product Writing, Number Exercise Type Expiry Option
of description purchasing, of price date money
relevant selling, securities per unit paid/
security varying etc to which received
option per unit
relates
ADR Call Options Purchasing 3,600 175 USD American 18 Jan 2019 3.3600 USD
ADR Put Options Purchasing 7,500 145 USD American 18 Jan 2019 0.2500 USD
ADR Put Options Selling 10,000 165 USD American 18 Jan 2019 1.8000 USD

(ii) Exercise

Class of relevant security Product description

e.g. call option

 Exercising/ exercised against Number of securities Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security Nature of dealing

e.g. subscription, conversion

 Details Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached? YES
Date of disclosure: 3 Jan 2019
Contact name: Large Holdings Regulatory Operations
Telephone number: 020 3134 7213

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN STOCK-SETTLED DERIVATIVE (INCLUDING OPTION) POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the 'Code')

1. KEY INFORMATION

Identity of the person whose positions/dealings Barclays PLC.
are being disclosed:
Name of offeror/offeree in relation to whose SHIRE PLC
relevant securities this from relates:

2. STOCK-SETTLED DERIVATIVES (INCLUDING OPTIONS)

Class Product Writing, Number Exercise Type Expiry
of description purchasing, of price date
relevant selling, securities per unit
security varying etc to which
option
relates
ADR Call Options Purchased 100 110.0000 American 17 Jan 2020
ADR Call Options Purchased 100 195.0000 American 19 Jul 2019
ADR Call Options Purchased 100 155.0000 American 15 Jan 2021
ADR Call Options Purchased 100 195.0000 American 15 Jan 2021
ADR Call Options Purchased 100 173.0000 American 18 Jan 2019
ADR Call Options Purchased 100 105.0000 American 18 Jan 2019
ADR Call Options Purchased 100 220.0000 American 18 Jan 2019
ADR Call Options Purchased 100 140.0000 American 18 Jan 2019
ADR Call Options Purchased 100 190.0000 American 4 Jan 2019
ADR Call Options Purchased 200 210.0000 American 18 Jan 2019
ADR Call Options Purchased 200 155.0000 American 17 Jan 2020
ADR Call Options Purchased 200 130.0000 American 17 Jan 2020
ADR Call Options Purchased 200 135.0000 American 17 Jan 2020
ADR Call Options Purchased 200 160.0000 American 17 Jan 2020
ADR Call Options Purchased 200 120.0000 American 17 Jan 2020
ADR Call Options Purchased 300 115.0000 American 18 Jan 2019
ADR Call Options Purchased 400 170.0000 American 17 Jan 2020
ADR Call Options Purchased 400 230.0000 American 18 Jan 2019
ADR Call Options Purchased 500 150.0000 American 18 Jan 2019
ADR Call Options Purchased 500 180.0000 American 18 Apr 2019
ADR Call Options Purchased 600 173.0000 American 28 Dec 2018
ADR Call Options Purchased 700 175.0000 American 28 Dec 2018
ADR Call Options Purchased 900 195.0000 American 18 Apr 2019
ADR Call Options Purchased 1,000 180.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 190.0000 American 11 Jan 2019
ADR Call Options Purchased 1,000 135.0000 American 18 Jan 2019
ADR Call Options Purchased 1,000 185.0000 American 19 Jul 2019
ADR Call Options Purchased 1,000 175.0000 American 19 Jul 2019
ADR Call Options Purchased 1,000 170.0000 American 19 Jul 2019
ADR Call Options Purchased 1,400 230.0000 American 15 Jan 2021
ADR Call Options Purchased 1,700 195.0000 American 17 Jan 2020
ADR Call Options Purchased 2,000 150.0000 American 17 Jan 2020
ADR Call Options Purchased 2,000 165.0000 American 18 Apr 2019
ADR Call Options Purchased 2,100 190.0000 American 18 Apr 2019
ADR Call Options Purchased 2,600 185.0000 American 18 Apr 2019
ADR Call Options Purchased 3,100 155.0000 American 18 Jan 2019
ADR Call Options Purchased 3,600 175.0000 American 18 Apr 2019
ADR Call Options Purchased 3,800 125.0000 American 18 Jan 2019
ADR Call Options Purchased 4,300 170.0000 American 18 Apr 2019
ADR Call Options Purchased 5,700 160.0000 American 19 Jul 2019
ADR Call Options Purchased 7,700 155.0000 American 18 Apr 2019
ADR Call Options Purchased 9,200 200.0000 American 15 Jan 2021
ADR Call Options Purchased 18,200 160.0000 American 18 Jan 2019
ADR Call Options Purchased 20,700 175.0000 American 18 Jan 2019
ADR Call Options Purchased 22,300 200.0000 American 18 Jan 2019
ADR Call Options Purchased 23,900 195.0000 American 18 Jan 2019
ADR Call Options Purchased 137,900 190.0000 American 18 Jan 2019
ADR Call Options Written -56,000 200.0000 American 17 Jan 2020
ADR Call Options Written -42,400 200.0000 American 19 Jul 2019
ADR Call Options Written -33,100 185.0000 American 18 Jan 2019
ADR Call Options Written -31,000 180.0000 American 18 Jan 2019
ADR Call Options Written -7,400 240.0000 American 17 Jan 2020
ADR Call Options Written -4,200 165.0000 American 18 Jan 2019
ADR Call Options Written -2,700 145.0000 American 18 Jan 2019
ADR Call Options Written -2,400 130.0000 American 18 Jan 2019
ADR Call Options Written -1,500 210.0000 American 19 Jul 2019
ADR Call Options Written -1,000 85.0000 American 18 Jan 2019
ADR Call Options Written -800 155.0000 American 18 Apr 2019
ADR Call Options Written -800 170.0000 American 18 Jan 2019
ADR Call Options Written -700 163.0000 American 28 Dec 2018
ADR Call Options Written -600 160.0000 American 18 Jan 2019
ADR Call Options Written -500 135.0000 American 19 Jul 2019
ADR Call Options Written -300 160.0000 American 18 Apr 2019
ADR Call Options Written -100 150.0000 American 18 Apr 2019
ADR Call Options Written -100 140.0000 American 17 Jan 2020
ADR Put Options Purchased -257,200 165.0000 American 18 Jan 2019
ADR Put Options Purchased -41,400 135.0000 American 18 Jan 2019
ADR Put Options Purchased -15,600 160.0000 American 18 Apr 2019
ADR Put Options Purchased -5,900 180.0000 American 18 Jan 2019
ADR Put Options Purchased -5,300 165.0000 American 15 Jan 2021
ADR Put Options Purchased -5,000 170.0000 American 18 Jan 2019
ADR Put Options Purchased -4,200 155.0000 American 18 Jan 2019
ADR Put Options Purchased -3,700 145.0000 American 17 Jan 2020
ADR Put Options Purchased -3,500 140.0000 American 18 Jan 2019
ADR Put Options Purchased -2,900 175.0000 American 18 Jan 2019
ADR Put Options Purchased -2,700 80.0000 American 18 Jan 2019
ADR Put Options Purchased -2,600 160.0000 American 15 Jan 2021
ADR Put Options Purchased -2,500 120.0000 American 17 Jan 2020
ADR Put Options Purchased -2,300 175.0000 American 4 Jan 2019
ADR Put Options Purchased -2,300 85.0000 American 18 Jan 2019
ADR Put Options Purchased -2,100 150.0000 American 18 Jan 2019
ADR Put Options Purchased -2,000 80.0000 American 17 Jan 2020
ADR Put Options Purchased -2,000 130.0000 American 15 Jan 2021
ADR Put Options Purchased -1,800 115.0000 American 18 Jan 2019
ADR Put Options Purchased -1,700 160.0000 American 17 Jan 2020
ADR Put Options Purchased -1,400 165.0000 American 17 Jan 2020
ADR Put Options Purchased -1,200 135.0000 American 17 Jan 2020
ADR Put Options Purchased -1,100 170.0000 American 17 Jan 2020
ADR Put Options Purchased -1,100 70.0000 American 17 Jan 2020
ADR Put Options Purchased -1,000 155.0000 American 15 Jan 2021
ADR Put Options Purchased -800 150.0000 American 17 Jan 2020
ADR Put Options Purchased -600 180.0000 American 18 Apr 2019
ADR Put Options Purchased -500 140.0000 American 17 Jan 2020
ADR Put Options Purchased -400 165.0000 American 19 Jul 2019
ADR Put Options Purchased -200 65.0000 American 17 Jan 2020
ADR Put Options Purchased -100 75.0000 American 17 Jan 2020
ADR Put Options Purchased -100 195.0000 American 15 Jan 2021
ADR Put Options Written 100 110.0000 American 18 Jan 2019
ADR Put Options Written 100 110.0000 American 17 Jan 2020
ADR Put Options Written 100 95.0000 American 18 Jan 2019
ADR Put Options Written 200 100.0000 American 18 Jan 2019
ADR Put Options Written 200 200.0000 American 17 Jan 2020
ADR Put Options Written 1,000 147.0000 American 28 Dec 2018
ADR Put Options Written 1,000 90.0000 American 18 Jan 2019
ADR Put Options Written 1,800 185.0000 American 18 Jan 2019
ADR Put Options Written 2,300 130.0000 American 18 Jan 2019
ADR Put Options Written 4,000 165.0000 American 18 Apr 2019
ADR Put Options Written 5,300 120.0000 American 18 Jan 2019
ADR Put Options Written 6,900 170.0000 American 18 Apr 2019
ADR Put Options Written 11,000 160.0000 American 19 Jul 2019
ADR Put Options Written 13,800 155.0000 American 18 Apr 2019
ADR Put Options Written 19,900 165.0000 American 18 Jan 2019
ADR Put Options Written 29,300 125.0000 American 18 Jan 2019
ADR Put Options Written 89,500 160.0000 American 18 Jan 2019
ADR Put Options Written 280,400 145.0000 American 18 Jan 2019

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to cash-settled derivatives.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

View source version on businesswire.com:https://www.businesswire.com/news/home/20190103005367/en/

BARCLAYS PLC

Source: BARCLAYS PLC

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Shire plc published this content on 03 January 2019 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 03 January 2019 13:28:02 UTC