In a statement, the Commission said Takeda had agreed to the sale in order to ensure that the drug in Shire's product pipeline aimed at treating inflammatory bowel disease would continue its way to the market, where it is expected to compete with Entyvio, Takeda's biggest-selling drug.

Reuters reported the approval was expected on Nov. 9.

Takeda has already secured unconditional clearance from regulators in the United States, Japan, China and Brazil.

(Reporting by Alastair Macdonald)