4basebio PLC announced a strategic research collaboration between its wholly owned subsidiary 4basebio Discovery Limited and eTheRNA immunotherapies. Under the Strategic Research Collaboration, the companies will be collaborating on the use of 4basebio's synthetic osDNA™ technology as a template for eTheRNA‘s in vitro mRNA production. The successful outcome of this project will pave the way for the use of a novel, high-performance and cost-effective DNA template for IVT mRNA synthesis.

mRNA technology has come into focus as a drug class to treat a wide variety of diseases with high unmet medical needs, exemplified by the success of vaccines to treat COVID-19. Normally, linearised plasmid DNA is used as a starting template for in vitro transcription (IVT) into mRNA. This mRNA is then translated in a patient's cells to produce proteins that could prevent or treat disease.