4basebio UK Societas announced it has filed a patent application for a novel protected and stabilized linear synthetic DNA type, “osDNA™”. DNA is susceptible to degradation by nucleases which are naturally occurring enzymes within organisms and which have a vital role in the regulation of many cellular processes, while also protecting against foreign DNA species. Enzymatic DNA degradation can render gene therapies ineffective and is a substantial consideration when developing gene therapies or DNA vaccines. The Company’s novel osDNA™ product has demonstrated increased longevity compared to conventional DNA types. Unlike hpDNA™ which is a closed DNA construct, osDNA™ is open linear DNA and incorporates all of the established benefits of hpDNA™ over widely used plasmid DNA, in particular the absence of bacterial backbone, antibiotic resistance genes or endotoxins. osDNA™ therefore also benefits from a high level of purity. Furthermore, a long terminal mono-nucleotide sequence (homopolymeric sequence) is an essential feature of high-quality mRNA. These types of sequences are known to be difficult to manufacture through plasmid fermentation. osDNA™ is readily able to incorporate these sequences, positioning osDNA™ as a highly suited template for the production of mRNA products, an area of significant commercial opportunity for the Company’s products and technologies.