GAITHERSBURG -
The preclinical studies were conducted at Altimmune's collaborating institutions, the University of Alabama at
The data, which were obtained in the K18-hACE2 transgenic mouse model, showed that a single intranasal dose of AdCOVID provided 100% protection against a lethal challenge from the SARS-CoV-2 virus. In these studies, which were performed in the laboratories of
'These data are very promising in my view. They show that AdCOVID conferred protection not only against COVID-19 related death, but also against any clinical signs of infection in the mice,' stated
UAB previously demonstrated that serum IgG and respiratory mucosal IgA titers in mice treated with AdCOVID were maintained for at least 6 months following a single intranasal vaccination and that memory B cells specific for spike antigen were found in the lymph nodes when assessed 5.5 months post-vaccination. Together, these new data demonstrate that a single vaccination with AdCOVID in preclinical models leads to a long-lived systemic and mucosal immune responses against the SARS-CoV-2 virus, important for sustained protection from disease.
'The data from these preclinical studies only reinforce our high expectations for the ongoing Phase 1 study of AdCOVID launched this quarter,' said Dr.
About AdCOVID
AdCOVID is a single-dose intranasal vaccine candidate for COVID-19. It is designed to stimulate a broad immune response including both systemic immunity (neutralizing antibody) and local immunity (mucosal IgA, resident memory T cells) in the nasal cavity and respiratory tract.
In published preclinical studies conducted in collaboration with the
Based on data from Altimmune's other intranasal platform vaccine candidates, AdCOVID is expected to have extended stability at room temperature that would allow for cold chain-free shipment of the vaccine. If demonstrated, AdCOVID could be stored in the common refrigerators found in community-based doctors' offices and pharmacies for two years or more. The Company believes that these simple and convenient handling requirements, together with the potential ability to block SARS-CoV-2 transmission, could position AdCOVID as a leading intranasal COVID-19 vaccine. Altimmune recently started a Phase 1 clinical trial of AdCOVID and anticipates having a data readout from this trial in the second quarter of 2021
About Altimmune
Altimmune is a clinical stage biopharmaceutical company focused on developing intranasal vaccines, immune modulating therapies and treatments for liver disease. Our diverse pipeline includes proprietary intranasal vaccines for COVID-19 (AdCOVID), anthrax (NasoShield) and influenza (NasoVAX); an intranasal immune modulating therapeutic for COVID-19 (T-COVID) and next generation peptide therapeutics for NASH (ALT-801) and chronic hepatitis B (HepTcell).
Forward-Looking Statement for Altimmune
Any statements made in this press release relating to future financial or business performance, conditions, plans, prospects, trends, or strategies and other financial and business matters, including without limitation, the timing of key milestones for our clinical assets, the timing of the data readout from the AdCOVID Phase 1 clinical trial in Q2 2021, the potential immunization effects of AdCOVID, the potential of AdCOVID to block SARS-CoV-2 transmission, the shipping and storage requirements for AdCOVID, the prospects for regulatory approval, our ability to manufacture AdCOVID for our clinical trials and commercial needs, and commercializing or selling any product or drug candidates, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.
In addition, when or if used in this press release, the words 'may,' 'could,' 'should,' 'anticipate,' 'believe,' 'estimate,' 'expect,' 'intend,' 'plan,' 'predict' and similar expressions and their variants, as they relate to
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