On November 27, 2023, Mr. Darren Lui resigned from his position as Aptorum Group Limited?s Chief Accounting Officer and as an Executive Director of the Board of Directors, to focus on his personal goals and pursuits. On November 30, 2023, Dr. Clark Cheng also resigned from his position as the Company?s Chief Medical Officer and as an Executive Director of the Board of Directors, to focus on his personal goals and pursuits. Mr. Ian Huen, one of the Company?s directors, who also served as the Company?s Chief Executive Officer from October 2017 until his prior resignation in June 2022, will step back into the role of Chief Executive Officer.

Neither Mr. Lui or Dr. Cheng?s resignation was a result of any disagreement with the Company relating to its operations, policies or practices. The Board is grateful for Mr. Lui and Dr. Cheng?s significant contribution to the Company over the years, and expresses its gratitude for their dedicated service to the Company during their tenures.