CSPC Pharmaceutical : VOLUNTARY ANNOUNCEMENT - INVESTIGATIONAL NEW DRUG "ALMB-0168" OBTAINS CLINICAL TRIAL APPROVAL IN CHINA

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CSPC Pharmaceutical Group Limited

石 藥 集 團 有 限 公 司

(Incorporated in Hong Kong with limited liability)

(Stock Code: 1093)

VOLUNTARY ANNOUNCEMENT

INVESTIGATIONAL NEW DRUG "ALMB-0168"

OBTAINS CLINICAL TRIAL APPROVAL IN CHINA

The board of directors (the "Board") of CSPC Pharmaceutical Group Limited (the "Company", together with its subsidiaries, the "Group") is pleased to announce that AlaMab Therapeutics (Shanghai) Inc.*（上海恩樂邁生物科技有限公司）, a subsidiary of the Company, has obtained approval from the National Medical Products Administration of the People's Republic of China for conducting clinical trial of the investigational new drug ALMB-0168 for the treatment of bone cancer and bone metastasis in China.

ALMB-0168 is a first-in-class humanized monoclonal antibody agonist for novel target hemichannel connexin 43 membrane protein, which is independently developed by AlaMab Therapeutics Inc. ("AlaMab"), a subsidiary of the Company, for the treatment of serious diseases with unmet medical needs, including bone cancer, bone metastasis and osteoporosis. ALMB-0168 has been granted orphan-drug designation and rare pediatric disease designation by the U.S. FDA in 2019 for the treatment of bone cancer, and a multi-center phase I clinical trial is currently being conducted in Australia.

AlaMab is an innovative biopharmaceutical company in the U.S. dedicated to the research and development of first-in-class antibody drugs. ALMB-0166, another product of AlaMab for the same target but with different mechanisms, is currently under phase I clinical trial for the treatment of acute spinal cord injury. AlaMab is making unremitting efforts to expedite the research and development progress of these two drug candidates.

By Order of the Board

CSPC Pharmaceutical Group Limited

Cai Dongchen

Chairman

Hong Kong, 15 September 2020

• For identification purpose only

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As at the date of this announcement, the Board comprises Mr. CAI Dongchen, Mr. ZHANG Cuilong, Mr. WANG Zhenguo, Mr. PAN Weidong, Mr. WANG Huaiyu, Dr. LI Chunlei, Dr. WANG Qingxi and Mr. CHAK Kin Man as executive directors; Mr. LEE Ka Sze, Carmelo as non-executive director; and Mr. CHAN Siu Keung, Leonard, Mr. WANG Bo, Professor LO Yuk Lam, Dr. YU Jinming and Mr. CHEN Chuan as independent non-executive directors.

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