CSPC Pharmaceutical : VOLUNTARY ANNOUNCEMENT - PASSING OF CONSISTENCY EVALUATION FOR "DOXORUBICIN HYDROCHLORIDE LIPOSOME INJECTION"

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CSPC PHARMACEUTICAL GROUP LIMITED

石 藥 集 團 有 限 公 司

(Incorporated in Hong Kong with limited liability)

(Stock code: 1093)

VOLUNTARY ANNOUNCEMENT

PASSING OF CONSISTENCY EVALUATION FOR

"DOXORUBICIN HYDROCHLORIDE LIPOSOME INJECTION"

The board of directors (the "Board") of CSPC Pharmaceutical Group Limited (the "Company", together with its subsidiaries, the "Group") is pleased to announce that the "Doxorubicin Hydrochloride Liposome Injection (10ml:20mg)" (brand name: Duomeisu（多美素）) (the "Product") developed by CSPC Ouyi Pharmaceutical Co., Ltd.*（石藥集團歐意藥業有限公司）, a subsidiary of the Company, has been granted approval by the National Medical Products Administration of the People's Republic of China for passing the consistency of quality and efficacy evaluation of generic drugs (the "Consistency Evaluation"), being the first product of this type passing the Consistency Evaluation in China.

Doxorubicin hydrochloride, an anthracycline antibiotic, is a broad-spectrumanti-tumor drug with cytotoxic effects by the inhibition of DNA, RNA and protein synthesis. It can be indicated for the treatment of AIDS-related Kaposi's sarcoma (AIDS-KS) in patients with low CD4 count (<200 CD4 lymphocytes/mm3) and extensive mucocutaneous or visceral disease. The Product can be used as first-line systemic chemotherapy or as second-line chemotherapy in AIDS-KS patients with progression or in patents intolerant to prior combination chemotherapy comprising at least two of the following agents: vincristine, bleomycin and standard doxorubicin (or other anthracycline antibiotics).

Duomeisu is one of the key anti-tumor products of the Group. The passing of the Consistency Evaluation signifies that the Group's high-endnano-preparation technology has reached the advanced international standard.

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By Order of the Board

CSPC Pharmaceutical Group Limited

Cai Dongchen

Chairman

Hong Kong, 11 May 2021

As at the date of this announcement, the Board comprises Mr. CAI Dongchen, Mr. ZHANG Cuilong, Mr. WANG Zhenguo, Mr. PAN Weidong, Mr. WANG Huaiyu, Dr. LI Chunlei, Dr. WANG Qingxi, Mr. CHAK Kin Man and Dr. JIANG Hao as executive directors; and Mr. WANG Bo, Mr. CHEN Chuan, Prof. WANG Hongguang, Mr. AU Chun Kwok Alan and Mr. LAW Cheuk Kin Stephen as independent non-executive directors.

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