Management's Discussion and Analysis of Financial Condition and Results of
Operations ("MD&A") is designed to provide material information relevant to an
assessment of Danaher's financial condition and results of operations, including
an evaluation of the amounts and certainty of cash flows from operations and
from outside sources. The MD&A is designed to focus specifically on material
events and uncertainties known to management that are reasonably likely to cause
reported financial information not to be necessarily indicative of future
operating results or of future financial condition. This includes descriptions
and amounts of matters that have had a material impact on reported operations,
as well as matters that are reasonably likely based on management's assessment
to have a material impact on future operations. The Company's MD&A is divided
into five sections:

•Overview

•Results of Operations

•Liquidity and Capital Resources

•Critical Accounting Estimates

•New Accounting Standards



This discussion and analysis should be read together with Danaher's audited
financial statements and related Notes thereto as of December 31, 2021 and 2020
and for each of the three years in the period ended December 31, 2021 included
in this Annual Report. Management's discussion and analysis of financial
condition and results of operations for 2019 is included in Item 7 of the
Company's Annual Report on Form 10-K with respect to the year ended December 31,
2020 filed with the Securities and Exchange Commission and should be referred to
for information regarding this period.

Unless otherwise indicated, all financial results in this report refer to continuing operations.



OVERVIEW

General

Refer to "Item 1. Business-General" for a discussion of Danaher's strategic
objectives and methodologies for delivering long-term shareholder value. Danaher
is a multinational business with global operations. During 2021, approximately
62% of Danaher's sales were derived from customers outside the United States. As
a diversified, global business, Danaher's operations are affected by worldwide,
regional and industry-specific economic and political factors. Danaher's
geographic and industry diversity, as well as the range of its products and
services, help limit the impact of any one industry or the economy of any single
country on its consolidated operating results. The Company's individual
businesses monitor key competitors and customers, including to the extent
possible their sales, to gauge relative performance and the outlook for the
future.

As a result of the Company's geographic and industry diversity, the Company
faces a variety of opportunities and challenges, including rapid technological
development (particularly with respect to computing, automation, artificial
intelligence, mobile connectivity, communications and digitization) in most of
the Company's served markets, the expansion and evolution of opportunities in
high-growth markets, trends and costs associated with a global labor force,
consolidation of the Company's competitors and increasing regulation. The
Company operates in a highly competitive business environment in most markets,
and the Company's long-term growth and profitability will depend in particular
on its ability to expand its business in high-growth geographies and high-growth
market segments, identify, consummate and integrate appropriate acquisitions and
identify and consummate appropriate investments and strategic partnerships,
develop innovative and differentiated new products and services with higher
gross profit margins, expand and improve the effectiveness of the Company's
sales force, continue to reduce costs and improve operating efficiency and
quality, and effectively address the demands of an increasingly regulated global
environment. The Company is making significant investments, organically and
through acquisitions and investments, to address the rapid pace of technological
change in its served markets and to globalize its manufacturing, research and
development and customer-facing resources (particularly in high-growth markets)
in order to be responsive to the Company's customers throughout the world and
improve the efficiency of the Company's operations.

Business Performance



Consolidated revenues for the year ended December 31, 2021 increased 32.0% as
compared to 2020. Foreign currency exchange rates contributed 1.5% and
acquisitions contributed 7.5% to the increase in revenues in 2021. Core sales
increased 23.0% in 2021 compared to 2020 and core sales including Cytiva
increased 25.0% in 2021 compared to 2020 (for the definition of "core sales" and
"core sales including Cytiva" refer to "-Results of Operations" below). While
differences exist among the

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Company's businesses, on an overall basis, demand for the Company's products and
services increased on a year-over-year basis in 2021 as compared to 2020, and
together with the Company's continued investments in sales growth initiatives
and the other business-specific factors contributed to the core sales growth
discussed below. As the conditions related to the pandemic improved in many
geographies in 2021 compared to 2020, the Company generally experienced
increased demand in the end-markets it serves. In addition to the improving
pandemic conditions, development and production related to COVID-19 vaccines and
therapeutics among biotechnology and pharmaceutical customers continued to
generate strong demand for bioprocessing and genomic products in the Company's
Life Sciences segment and COVID-19 related testing generated strong demand
primarily in the Company's molecular diagnostics testing business in the
Diagnostics segment and in the Company's flow cytometry, genomics, lab
automation, centrifugation, particle counting and characterization business and
the genomics consumables business in the Life Sciences segment. Geographically,
both high-growth and developed markets contributed to year-over-year core sales
growth during 2021. Core sales in developed markets grew more than 20% in 2021
as compared to 2020 and were driven by North America and Western Europe. Core
sales in high-growth markets grew approximately 30% in 2021 as compared to 2020,
with broad-based growth across these markets, led by growth in China.
High-growth markets represented approximately 31% of the Company's total sales
in 2021.

The Company's net earnings from continuing operations for the year ended
December 31, 2021 totaled approximately $6.3 billion, compared to approximately
$3.6 billion for the year ended December 31, 2020. Net earnings attributable to
common stockholders for the year ended December 31, 2021 totaled approximately
$6.3 billion or $8.61 per diluted common share compared to approximately $3.5
billion or $4.89 per diluted common share for the year ended December 31, 2020.
The increase in net earnings in 2021 as compared to 2020 was driven by increased
sales in the Company's existing businesses and sales from acquired businesses,
partially offset by the impact of the modification and partial termination of a
prior commercial arrangement and resolution of the associated litigation. Refer
to "-Results of Operations" for further discussion of the year-over-year changes
in net earnings and diluted net earnings per common share for the year ended
December 31, 2021.

For a discussion of the impact of supply chain disruptions, labor availability constraints and increased labor costs on our businesses in 2021, please see "Item 1. Business - Materials."

The COVID-19 Pandemic



The global spread of a novel strain of coronavirus (COVID-19) has led to
unprecedented restrictions on, and disruptions in, business and personal
activities, including as a result of preventive and precautionary measures that
we, other businesses, our communities and governments have taken and are taking
to mitigate the spread of the virus and to manage its impact. The Company
continues to actively monitor the pandemic, including the current spread of
certain variants of the virus, and has taken and intends to continue taking
steps to identify and seek to mitigate the adverse impacts on, and risks to, the
Company's business (including but not limited to its employees, customers,
business partners, manufacturing capabilities and capacity, and supply and
distribution channels) posed by the spread of COVID-19 and the governmental and
community responses thereto. The Company's businesses have activated their
business continuity plans as a result of this pandemic, including taking steps
in an effort to help keep our workforce healthy and safe, and are assessing and
updating those plans on an ongoing basis. As a result of COVID-19 the Company's
businesses have modified certain of their respective business practices, and the
Company expects to take such further actions as may be required by government
authorities or as determined to be in the best interests of our employees,
customers and other business partners. The Company has developed and is
implementing return-to-workplace protocols designed to help ensure the health
and safety of its employees, customers and business partners, for its businesses
to apply as appropriate. Given that the prevalence of COVID-19 and the nature of
the response thereto (including the degree to which restrictions are being
relaxed or re-imposed) varies significantly by geography, the impact of the
pandemic on the Company's different business locations around the world at any
given time also varies significantly.

We are also deploying our capabilities, expertise and scale to address the critical health needs related to COVID-19. We have developed and made available diagnostic tests for the rapid detection of COVID-19. In addition, our businesses are providing critical support to firms that are developing and producing vaccines and therapies for COVID-19, among other support.



While we expect overall demand for the Company's COVID-19 related products to
moderate as and to the extent the pandemic subsides, as the pandemic evolves
toward endemic status we believe a level of demand for the Company's products
that support COVID-19 related vaccines and therapeutics (including initiatives
that seek to prevent or mitigate similar, future pandemics) and COVID-19 testing
will continue. However, on a relative basis, we expect the level of ongoing
demand for products supporting COVID-19 testing will be subject to more
fluctuations in demand than the level of demand for products supporting COVID-19
related vaccines and therapeutics. The Company's ability to satisfy COVID-19
related demand will also depend in part upon the expansion of our production
capacity in these areas.

Due to the speed with which the COVID-19 situation continues to evolve, the
global breadth of its spread, the range of governmental and community responses
thereto and our geographic and business line diversity, its further impact on
our

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business remains highly uncertain, but may be materially negative to certain
elements of our business. The potential negative impact will depend on future
developments including but not limited to:

•the degree of spread and severity of COVID-19 variants such as Omicron; and

•the timing and durability of continued recovery in the global demand for our non-COVID-19 related products and services.

For additional information on the risks of COVID-19 to the Company's operations, refer to the "Item 1A. Risk Factors" section of this Annual Report.

Acquisitions



On August 30, 2021, the Company acquired Aldevron, L.L.C. ("Aldevron") for a
cash purchase price of approximately $9.6 billion (the "Aldevron Acquisition").
Aldevron manufactures high-quality plasmid DNA, mRNA and proteins, serving
biotechnology and pharmaceutical customers across research, clinical and
commercial applications, and is now part of the Company's Life Sciences segment.
Aldevron generated revenues of approximately $300 million in 2020. The
acquisition of Aldevron is expected to provide additional sales and earnings
opportunities for the Company by expanding product line diversity, including new
product offerings supporting genomic medicine. The Company financed the Aldevron
Acquisition using cash on hand and proceeds from the issuance of commercial
paper.

In addition to the Aldevron Acquisition, during 2021 the Company acquired 13
other businesses for total consideration of approximately $1.4 billion in cash,
net of cash acquired. The businesses acquired complement existing units of each
of the Company's three segments. The aggregate annual sales of the 13 other
businesses acquired in 2021 at the time of their acquisition, in each case based
on the company's revenues for its last completed fiscal year prior to the
acquisition, were approximately $100 million.

Refer to Note 2 to the Consolidated Financial Statements for discussion regarding the Company's acquisitions.

RESULTS OF OPERATIONS



In this report, references to the non-GAAP measures of core sales (also referred
to as core revenues or sales/revenues from existing businesses) and core sales
including Cytiva refer to sales from continuing operations calculated according
to generally accepted accounting principles in the United States ("GAAP") but
excluding:

•sales from acquired businesses (as defined below, as applicable); and

•the impact of currency translation.



References to sales or operating profit attributable to acquisitions or acquired
businesses refer to sales or operating profit, as applicable, from acquired
businesses recorded prior to the first anniversary of the acquisition less any
sales and operating profit, during the applicable period, attributable to
divested product lines not considered discontinued operations; provided that in
calculating core sales including Cytiva, Cytiva's sales (net of the sales of the
Company product lines divested in 2020 to obtain regulatory approval to acquire
Cytiva, or the "divested product lines") ("Cytiva sales") are excluded from the
definition of sales attributable to acquisitions or acquired businesses. The
portion of revenue attributable to currency translation is calculated as the
difference between:

•the period-to-period change in revenue (excluding sales from acquired businesses (as defined above, as applicable)); and

•the period-to-period change in revenue (excluding sales from acquired businesses (as defined above, as applicable)) after applying current period foreign exchange rates to the prior year period.



As noted above, beginning with results for the second quarter of 2020, the
Company also presents core sales on a basis that includes Cytiva sales. Prior to
the acquisition of Cytiva, Danaher calculated core sales solely on a basis that
excluded sales from acquired businesses recorded prior to the first anniversary
of the acquisition. However, given Cytiva's significant size and historical core
sales growth rate, in each case compared to Danaher's existing businesses,
management believes it is appropriate to also present core sales on a basis that
includes Cytiva sales. Management believes this presentation provides useful
information to investors by demonstrating beginning immediately after the
acquisition Cytiva's impact on the Company's growth profile, rather than waiting
to demonstrate such impact until 12 months after the acquisition when Cytiva
would normally have been included in Danaher's core sales calculation. Danaher
calculates period-to-period core sales growth including Cytiva by adding Cytiva
sales to core sales for both the baseline and current periods. Beginning in the
second quarter

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of 2021, Cytiva sales are included in core sales, and therefore the measure "core sales including Cytiva" is no longer provided for quarterly periods beginning with the second quarter of 2021.



Core sales growth (and the related measure of core sales including Cytiva)
should be considered in addition to, and not as a replacement for or superior
to, sales, and may not be comparable to similarly titled measures reported by
other companies. Management believes that reporting these non-GAAP financial
measures provides useful information to investors by helping identify underlying
growth trends in Danaher's business and facilitating comparisons of Danaher's
revenue performance with its performance in prior and future periods and to
Danaher's peers. Management also uses these non-GAAP financial measures to
measure the Company's operating and financial performance, and uses core sales
growth as one of the performance measures in the Company's executive short-term
cash incentive program. The Company excludes the effect of currency translation
from these measures because currency translation is not under management's
control, is subject to volatility and can obscure underlying business trends,
and excludes the effect of acquisitions (other than Cytiva sales, in the case of
core sales growth including Cytiva) and divestiture-related items because the
nature, size, timing and number of acquisitions and divestitures can vary
dramatically from period-to-period and between the Company and its peers and can
also obscure underlying business trends and make comparisons of long-term
performance difficult.

Throughout this discussion, references to sales growth or decline refer to the
impact of both price and unit sales and references to productivity improvements
generally refer to improved cost efficiencies resulting from the ongoing
application of DBS.

The Company deems acquisition-related transaction costs incurred in a given period to be significant (generally relating to the Company's larger acquisitions) if it determines that such costs exceed the range of acquisition-related transaction costs typical for Danaher in a given period.

Core Sales Growth and Core Sales Growth Including Cytiva



                                                                             2021 vs. 2020           2020 vs. 2019
Total sales growth (GAAP)                                                            32.0  %                 24.5  %
Impact of:
Acquisitions/divestitures                                                            (7.5) %                (18.0) %
Currency exchange rates                                                              (1.5) %                    -  %
Core sales growth (non-GAAP)                                                         23.0  %                  6.5  %
Impact of Cytiva sales growth (net of divested product lines)                         2.0  %                  3.0  %
Core sales growth including Cytiva (non-GAAP)                                        25.0  %                  9.5  %


2021 Sales Compared to 2020

Total sales increased 32.0% on a year-over-year basis in 2021 primarily as a
result of an increase in core sales resulting from the factors discussed below
by segment as well as an increase in sales from acquired businesses, net of
divestitures, primarily due to the acquisition of Cytiva. The impact of currency
translation increased reported sales by 1.5% on a year-over-year basis in 2021
primarily due to the favorable impact of the weakening of the U.S. dollar
against most other major currencies in 2021.

Operating Profit Performance

Operating profit margins were 25.3% for the year ended December 31, 2021 as compared to 19.0% in 2020. The following factors impacted year-over-year operating profit margin comparisons.

2021 vs. 2020 operating profit margin comparisons were favorably impacted by:



•Higher 2021 core sales volumes, an increased proportion of sales of higher
margin product lines, incremental year-over-year cost savings associated with
continuing productivity improvement initiatives and the impact of foreign
currency exchange rates in 2021, net of incremental year-over-year costs
associated with various new product development and sales, service and marketing
growth investments and incremental year-over-year material and labor costs - 560
basis points

•2020 acquisition-related fair value adjustments to inventory and deferred
revenue, transaction costs deemed significant and integration preparation costs,
net of 2021 acquisition-related fair value adjustments to inventory and deferred
revenue in each case related to the acquisition of Cytiva - 210 basis points.

•The incremental accretive effect in 2021 of acquired businesses, net of product
line dispositions which did not qualify as discontinued operations - 60 basis
points

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•First quarter 2020 impairment charges related to a facility in the Diagnostics
segment and a trade name and other intangible assets in the Environmental &
Applied Solutions segment and a third quarter 2020 impairment charge related to
trade names in the Environmental & Applied Solutions segment, net of a first
quarter 2021 impairment charge related to a trade name in the Diagnostics
segment - 5 basis points

2021 vs. 2020 operating profit margin comparisons were unfavorably impacted by:



•Third quarter 2021 impact of the modification and partial termination of a
prior commercial arrangement and resolution of the associated litigation - 185
basis points

•Full year 2021 acquisition-related fair value adjustments to inventory and
transaction costs deemed significant, in each case related to the acquisition of
Aldevron - 20 basis points

Business Segments

Sales by business segment for the years ended December 31 are as follows ($ in
millions):

                                       2021          2020          2019
Life Sciences                       $ 14,958      $ 10,576      $  6,951
Diagnostics                            9,844         7,403         6,561

Environmental & Applied Solutions 4,651 4,305 4,399 Total

$ 29,453      $ 22,284      $ 17,911

For information regarding the Company's sales by geographical region, refer to Note 5 to the Consolidated Financial Statements.

LIFE SCIENCES



The Life Sciences segment offers a broad range of instruments and consumables
that are primarily used by customers to study the basic building blocks of life,
including genes, proteins, metabolites and cells, in order to understand the
causes of disease, identify new therapies, and test and manufacture new drugs
and vaccines.

Life Sciences Selected Financial Data



                                             Year Ended December 31
($ in millions)                        2021           2020           2019
Sales                               $ 14,958       $ 10,576       $ 6,951
Operating profit                       4,367          2,054         1,401
Depreciation                             258            183           130
Amortization of intangible assets      1,183            870           357
Operating profit as a % of sales        29.2  %        19.4  %       20.2  %
Depreciation as a % of sales             1.7  %         1.7  %        1.9  %
Amortization as a % of sales             7.9  %         8.2  %        5.1  %

Core Sales Growth and Core Sales Growth Including Cytiva



                                                                              2021 vs. 2020           2020 vs. 2019
Total sales growth (GAAP)                                                             41.5  %                 52.0  %
Impact of:
Acquisitions/divestitures                                                            (16.5) %                (46.5) %
Currency exchange rates                                                               (2.0) %                    -  %
Core sales growth (non-GAAP)                                                          23.0  %                  5.5  %
Impact of Cytiva sales growth (net of divested product lines)                          4.5  %                  7.5  %
Core sales growth including Cytiva (non-GAAP)                                         27.5  %                 13.0  %


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2021 Sales Compared to 2020

Price increases in the segment contributed 2.0% to sales growth on a year-over-year basis during 2021 as compared with 2020 and are reflected as a component of the change in core revenue growth.



During 2021, total Life Sciences segment sales increased 41.5% primarily as a
result of increased core sales resulting from the factors discussed below and
increased sales from acquisitions. In addition, the impact of currency
translation increased reported sales by 2.0% in 2021 compared to 2020, primarily
due to the favorable impact of the weakening of the U.S. dollar in 2021 compared
to 2020. On an overall basis, in 2021 the Life Sciences segment saw continued
strong demand for products supporting customers in the pursuit and production of
COVID-19-related vaccines and therapeutics as well as broad strength across its
other product lines. In 2021, core sales for the filtration, separation and
purification technologies business increased compared to 2020 due to strong
demand for these products led by the biopharmaceutical and the microelectronics
end-markets, partially offset by weaker demand in the aerospace end-market.
Geographically, core sales for the business were led by North America, Western
Europe and China. Core sales for the Company's flow cytometry, genomics, lab
automation, centrifugation, particle counting and characterization business
increased in 2021 across all major geographies, led by North America and Western
Europe. Core sales for the business were driven by demand earlier in the year
for genomic sample preparation consumables related to COVID-19 as well as demand
for flow cytometry products. Core sales in the mass spectrometry business
increased in 2021 across all major end-markets driven in part by demand for new
products. Geographically, demand for these products increased across all major
geographies, led by North America, Western Europe and China.

The acquisitions of Cytiva on March 31, 2020 (the "Cytiva Acquisition") and
Aldevron on August 30, 2021 have provided, and are expected to continue to
provide, additional sales and earnings growth opportunities for the Company's
Life Sciences segment by expanding the business' geographic and product line
diversity, including new product and service offerings that complement the
Company's bioprocessing workflow and genomic medicine solutions. In 2021, Cytiva
experienced significant increased year-over-year demand across all major
geographies, driven by continued strong demand for instruments and consumables
used in the research and development and production of COVID-19 related
treatments and vaccines and increased demand for non-COVID 19 related products
as well as by the completion of a major project in China. Since acquisition,
Aldevron has seen sales growth in all major product lines compared to the prior
year period.

Operating Profit Performance

Operating profit margins increased 980 basis points during 2021 as compared to 2020. The following factors impacted year-over-year operating profit margin comparisons.

2021 vs. 2020 operating profit margin comparisons were favorably impacted by:



•Higher 2021 core sales volumes, an increased proportion of sales of higher
margin product lines, incremental year-over-year cost savings associated with
continuing productivity improvement initiatives and the impact of foreign
currency exchange rates in 2021, net of incremental year-over-year costs
associated with various new product development and sales and marketing growth
investments and incremental year-over-year material and labor costs - 500 basis
points

•2020 acquisition-related fair value adjustments to inventory and deferred
revenue, transaction costs deemed significant and integration preparation costs,
net of 2021 acquisition-related fair value adjustments to inventory and deferred
revenue in each case related to the acquisition of Cytiva - 440 basis points

•The incremental accretive effect in 2021 of acquired businesses, net of product
line dispositions which did not qualify as discontinued operations - 80 basis
points

2021 vs. 2020 operating profit margin comparisons were unfavorably impacted by:



•Full year 2021 acquisition-related fair value adjustments to inventory and
transaction costs deemed significant, in each case related to the acquisition of
Aldevron - 40 basis points

Depreciation and amortization of intangible assets as a percentage of sales were relatively consistent in 2021 as compared with 2020.

DIAGNOSTICS

The Diagnostics segment offers clinical instruments, reagents, consumables, software and services that hospitals, physicians' offices, reference laboratories and other critical care settings use to diagnose disease and make treatment decisions.


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Diagnostics Selected Financial Data



                                            Year Ended December 31
($ in millions)                        2021          2020          2019
Sales                               $ 9,844       $ 7,403       $ 6,561
Operating profit                      2,313         1,538         1,134
Depreciation                            409           397           376
Amortization of intangible assets       205           205           206
Operating profit as a % of sales       23.5  %       20.8  %       17.3  %
Depreciation as a % of sales            4.2  %        5.4  %        5.7  %
Amortization as a % of sales            2.1  %        2.8  %        3.1  %


Core Sales Growth

                                2021 vs. 2020      2020 vs. 2019
Total sales growth (GAAP)              33.0  %            13.0  %
Impact of:
Acquisitions/divestitures              (0.5) %               -  %
Currency exchange rates                (1.5) %             0.5  %
Core sales growth (non-GAAP)           31.0  %            13.5  %


2021 Sales Compared to 2020

Price increases in the segment contributed 0.5% to sales growth on a year-over-year basis during 2021 as compared with 2020 and are reflected as a component of the change in core sales growth.



During 2021, total Diagnostics segment sales increased 33.0% primarily as a
result of increased core sales resulting from the factors discussed below. In
addition, the impact of currency translation increased reported sales by 1.5%,
primarily due to the favorable impact of the weakening of the U.S. dollar in
2021 compared to 2020, and the impact of sales from acquisitions increased
reported sales by 0.5% in 2021. During 2021, the Diagnostics segment experienced
higher year-over-year sales for molecular diagnostics tests for COVID-19. Demand
across the other Diagnostics segment businesses also increased with non-COVID
product lines testing volumes improving as individuals resumed visits to
healthcare providers following the easing of shutdowns and restrictions related
to the pandemic. In 2021, core sales in the segment's clinical lab business
increased on a year-over-year basis across all major geographies driven
primarily by continued increased demand in the chemistry and immunoassay product
lines. During 2021, core sales in the molecular diagnostics business grew on a
year-over-year basis in both developed and high-growth markets, which
contributed significantly to overall segment core sales growth. The business
continued to experience strong growth in sales of consumables, driven primarily
by increased sales of diagnostic test solutions for COVID-19, as increased
production capacity allowed the business to produce more diagnostic tests in
response to continued market growth, and higher year-over-year demand for
testing for non-respiratory diseases. Core sales in the acute care diagnostic
business increased year-over-year due to continued strong demand for blood gas
consumables and immunoassay products, partially offset by lower year-over-year
instrument sales largely due to strong COVID-19 related demand for blood gas
instruments in 2020. Geographically, demand was strong across most major
geographies. Core sales in the pathology business grew year-over-year across all
major geographies, driven by increased demand for core histology, advanced
staining and pathology imaging products.

Operating Profit Performance

Operating profit margins increased 270 basis points during 2021 as compared to 2020. The following factors impacted year-over-year operating profit margin comparisons.

2021 vs. 2020 operating profit margin comparisons were favorably impacted by:



•Higher 2021 core sales volumes, an increased proportion of sales of higher
margin product lines, incremental year-over-year cost savings associated with
continuing productivity improvement initiatives and the impact of foreign
currency exchange rates in 2021, net of incremental year-over-year costs
associated with various new product development, sales, service and marketing
growth investments and incremental year-over-year material and labor costs - 810
basis points

•The incremental accretive effect in 2021 of acquired businesses - 20 basis points


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2021 vs. 2020 operating profit margin comparisons were unfavorably impacted by:



•Third quarter 2021 impact of the modification and partial termination of a
prior commercial arrangement and resolution of the associated litigation - 555
basis points

•First quarter 2021 impairment charge related to a trade name, net of a first quarter 2020 impairment charge related to a facility - 5 basis points

Depreciation and amortization of intangible assets both decreased as a percentage of sales during 2021 as compared with 2020, primarily as a result of the increase in sales.

ENVIRONMENTAL & APPLIED SOLUTIONS



The Environmental & Applied Solutions segment offers products and services that
help protect precious resources and keep global food and water supplies safe.
The Company's water quality business provides instrumentation, consumables,
software, services and disinfection systems to help analyze, treat and manage
the quality of ultra-pure, potable, industrial, waste, ground, source and ocean
water in residential, commercial, municipal, industrial and natural resource
applications. The Company's product identification business provides
instruments, software, services and consumables for various color and appearance
management, packaging design and quality management, packaging converting,
printing, marking, coding and traceability applications for consumer,
pharmaceutical and industrial products.

Environmental & Applied Solutions Selected Financial Data



                                            Year Ended December 31
($ in millions)                        2021          2020          2019
Sales                               $ 4,651       $ 4,305       $ 4,399
Operating profit                      1,054           979         1,052
Depreciation                             44            47            49
Amortization of intangible assets        62            63            62
Operating profit as a % of sales       22.7  %       22.7  %       23.9  %
Depreciation as a % of sales            0.9  %        1.1  %        1.1  %
Amortization as a % of sales            1.3  %        1.5  %        1.4  %


Core Sales Growth (Decline)

                                          2021 vs. 2020      2020 vs. 2019
Total sales growth (decline) (GAAP)               8.0  %            (2.0) %
Impact of:
Acquisitions/divestitures                         1.5  %               -  %
Currency exchange rates                          (1.5) %             0.5  %
Core sales growth (decline) (non-GAAP)            8.0  %            (1.5) %


2021 Sales Compared to 2020

Price increases in the segment contributed 1.5% to sales growth on a year-over-year basis during 2021 as compared with 2020 and are reflected as a component of the change in core revenue growth.



In 2021, total Environmental & Applied Solutions segment sales increased 8.0%,
primarily as a result of core sales growth driven by the factors discussed
below. The impact of currency translation increased reported sales 1.5% in 2021,
primarily due to the favorable impact of the weakening of the U.S. dollar in
2021 compared to 2020. Divestitures, net of acquisitions, decreased reported
sales by 1.5% in 2021.

On an overall basis, in 2021 the segment's water quality businesses increased at
a mid-single digit rate due to continuing demand for consumables and increased
demand for equipment on a year-over-year basis, driven in part by the recovery
from the decline in equipment demand in 2020 as a result of the COVID-19
pandemic. Year-over-year core sales in the analytical instrumentation product
line increased driven by demand in North America, Western Europe and China and
by demand in the municipal and industrial end-markets. Core sales in the
chemical treatment solutions product line increased as a result of demand in the
chemical, commercial and industry and food and beverage end-markets, driven by
North America.

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The segment's product identification businesses grew at a low-double digit rate
due to continued demand for consumables along with an increase in demand for
equipment, driven in part by the recovery from lower equipment volumes in 2020
resulting from the COVID-19 pandemic. Core sales in the marking and coding
business increased across all major geographies and most major end-markets.
Year-over-year core sales in the packaging and color solutions products and
services business increased across most major geographies.

Operating Profit Performance

Operating profit margins were flat during 2021 as compared to 2020. The following factors impacted year-over-year operating profit margin comparisons.

2021 vs. 2020 operating profit margin comparisons were favorably impacted by:



•Impairment charges related to a trade name and other intangible assets in the
first quarter of 2020 and a trade name in the third quarter of 2020 - 45 basis
points

2021 vs. 2020 operating profit margin comparisons were unfavorably impacted by:



•Incremental year-over-year costs associated with sales, service and marketing
growth investments and incremental year-over-year material and labor costs, net
of higher 2021 core sales volumes, incremental year-over-year cost savings
associated with continuing productivity improvement initiatives and the impact
of foreign currency exchange rates in 2021 - 45 basis points

COST OF SALES AND GROSS PROFIT



                               Year Ended December 31
($ in millions)          2021           2020           2019
Sales                 $ 29,453       $ 22,284       $ 17,911
Cost of sales          (11,501)        (9,809)        (7,927)
Gross profit          $ 17,952       $ 12,475       $  9,984
Gross profit margin       61.0  %        56.0  %        55.7  %


The year-over-year increase in cost of sales during 2021 as compared with 2020
was due primarily to the impact of higher year-over-year sales volumes,
including sales volumes from recently acquired businesses and incremental
year-over-year material and labor costs. This increase was partially offset by
lower incremental year-over-year acquisition-related charges associated with
fair value adjustments to inventory in connection with acquisitions (the
acquisition of Aldevron in 2021 and Cytiva in 2020), which increased cost of
sales by $59 million in 2021 and $457 million in 2020.

The year-over-year increase in gross profit margin during 2021 as compared with
2020 was due primarily to higher year-over-year sales volumes, including sales
volumes from recently acquired businesses and the impact of the change in mix of
sales to higher margin product lines. The acquisition-related charges of $76
million incurred in 2021 associated with fair value adjustments to deferred
revenue related to the Cytiva Acquisition and fair value adjustments to
inventory in connection with the acquisitions of both Aldevron and Cytiva, were
lower than the $509 million of fair value adjustments to deferred revenue and
inventory recorded in 2020 related to the Cytiva Acquisition, which also
contributed to the increased gross profit margin in 2021. Gross profit margin
also benefited in 2021 from the inclusion of a full year of Cytiva sales
compared to only nine months in 2020.

OPERATING EXPENSES

                                                                           Year Ended December 31
($ in millions)                                                  2021               2020               2019
Sales                                                        $  29,453          $  22,284          $  17,911
Selling, general and administrative ("SG&A") expenses           (8,198)            (6,896)            (5,589)
Research and development ("R&D") expenses                       (1,742)            (1,348)            (1,126)
Other operating expenses                                          (547)                 -                  -
SG&A as a % of sales                                              27.8  %            30.9  %            31.2  %
R&D as a % of sales                                                5.9  %             6.0  %             6.3  %
Other operating expenses as a % of sales                           1.9  %               -  %               -  %


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SG&A expenses as a percentage of sales declined 310 basis points on a
year-over-year basis for 2021 compared with 2020. The decline was driven by the
benefit of increased leverage of the Company's general and administrative cost
base, including amortization expense, resulting from higher 2021 sales volumes,
including sales volumes from recently acquired businesses, incremental
year-over-year cost savings associated with continuing productivity improvement
initiatives and lower year-over-year impairment charges related to a facility, a
trade name and other intangible assets incurred in 2020, net of impairment
charges related to a trade name in 2021. The Company's 2021 transaction costs
for the acquisition of Aldevron were lower than 2020 transaction costs for the
acquisition of Cytiva, which also benefited SG&A as a percentage of sales during
2021. These decreases were partially offset by continued investments in sales
and marketing growth initiatives in 2021.

R&D expenses (consisting principally of internal and contract engineering
personnel costs) as a percentage of sales declined slightly in 2021 as compared
with 2020, primarily due to the sales growth rate exceeding the spending growth
related to new product development initiatives.

Other operating expenses and other operating expenses as a percentage of sales
increased in 2021 compared with 2020 as a result of the contract settlement
expense related to the modification and partial termination of a prior
commercial arrangement and resolution of the associated litigation during 2021.
Refer to Note 8 to the accompanying Consolidated Financial Statements.

NONOPERATING INCOME (EXPENSE)



Nonoperating income (expense) consists primarily of net unrealized and realized
gains/losses resulting from changes in the fair value of the Company's
investments in equity securities and investments in partnerships, the
non-service cost components of net periodic benefit costs and gains on the sale
of product lines. Refer to Note 9 in the Consolidated Financial Statements.

LOSS ON EARLY EXTINGUISHMENT OF BORROWINGS



In the fourth quarter of 2021, the Company redeemed the €800 million aggregate
principal amount of 2.5% senior unsecured notes due 2025 at a redemption price
equal to the outstanding principal amount and a make-whole premium as specified
in the applicable indenture, plus accrued and unpaid interest. The Company
recorded a loss on early extinguishment of these borrowings related to the
payment of the make-whole premiums and deferred costs in connection with the
redemption of $96 million ($73 million after-tax). The Company funded the
redemption using available cash balances, including proceeds from the fourth
quarter 2021 issuance of the $1.0 billion aggregate principal amount of 2.8%
senior unsecured notes due 2051.

In the fourth quarter of 2020, the Company redeemed the €800 million aggregate
principal amount of 1.7% senior unsecured notes due 2022 at a redemption price
equal to the outstanding principal amount and a make-whole premium as specified
in the applicable indenture, plus accrued and unpaid interest. The Company
recorded a loss on early extinguishment of these borrowings of $26 million ($20
million after-tax) related to the payment of make-whole premiums in connection
with the redemption. The Company funded the redemption using available cash
balances, including proceeds from the fourth quarter 2020 issuance of the $1.0
billion aggregate principal amount of 2.6% senior unsecured notes due 2050.

INTEREST COSTS



Interest expense of $238 million for 2021 was $37 million lower than in 2020,
due primarily to lower average debt balances in 2021 compared to 2020, partially
offset by the impact of the weaker U.S. dollar in 2021 on the interest expense
for the Company's foreign currency denominated debt (and U.S. dollar debt that
has been effectively converted into foreign currency through cross-currency swap
derivative contracts). Interest income of $11 million for 2021 was $60 million
lower than in 2020, due primarily to lower average cash balances in 2021 as a
result of the funding of the Cytiva Acquisition in 2020 and the Aldevron
Acquisition in 2021 and lower interest rates.

For a further description of the Company's debt and cross-currency swap derivative contracts related to the debt as of December 31, 2021 refer to Notes 14 and 15 to the Consolidated Financial Statements.

INCOME TAXES

General



Income tax expense and deferred tax assets and liabilities reflect management's
assessment of future taxes expected to be paid on items reflected in the
Company's Consolidated Financial Statements. The Company records the tax effect
of discrete items and items that are reported net of their tax effects in the
period in which they occur.

The Company's effective tax rate can be affected by changes in the mix of
earnings in countries with different statutory tax rates (including as a result
of business acquisitions and dispositions), changes in the valuation of deferred
tax assets and liabilities, accruals related to contingent tax liabilities and
period-to-period changes in such accruals, the results of audits and

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examinations of previously filed tax returns (as further discussed below), the
expiration of statutes of limitations, the implementation of tax planning
strategies, tax rulings, court decisions, settlements with tax authorities,
changes in tax laws and regulations, and legislative policy changes that may
result from the OECD's initiative on Base Erosion and Profit Shifting. For a
description of the tax treatment of earnings that are planned to be reinvested
indefinitely outside the United States, refer to "-Liquidity and Capital
Resources-Cash and Cash Requirements" below.

The amount of income taxes the Company pays is subject to ongoing audits by
federal, state and non-U.S. tax authorities, which often result in proposed
assessments. Management performs a comprehensive review of its global tax
positions on a quarterly basis. Based on these reviews, which take into account
the results of discussions and resolutions of matters with certain tax
authorities and the other factors referenced in the prior paragraph, reserves
for contingent tax liabilities are accrued or adjusted as necessary. For a
discussion of risks related to these and other tax matters, refer to "Item 1A.
Risk Factors".

Year-Over-Year Changes in the Tax Provision and Effective Tax Rate



                                                             Year Ended 

December 31


                                                          2021              

2020 2019


 Effective tax rate from continuing operations                  16.5  %     

18.9 % 26.4 %




The Company's effective tax rate for 2021 and 2020 differs from the U.S. federal
statutory rate of 21.0%, due principally to net discrete benefits related
primarily to the release of reserves for uncertain tax positions due to the
expiration of statutes of limitation and audit settlements, excess tax benefits
from stock-based compensation and the mix of earnings between the U.S. and
certain jurisdictions with lower overall tax rates, net of changes in estimates
associated with prior period uncertain tax positions. Refer to Note 7 to the
Consolidated Financial Statements for a discussion of the Company's effective
tax rate.

The Company conducts business globally, and files numerous consolidated and
separate income tax returns in the U.S. federal, state and non-U.S.
jurisdictions. The non-U.S. countries in which the Company has a significant
presence include China, Denmark, Germany, Singapore, Sweden, Switzerland and the
United Kingdom. Excluding these jurisdictions, the Company believes that a
change in the statutory tax rate of any individual non-U.S. country would not
have a material effect on the Company's Consolidated Financial Statements given
the geographic dispersion of the Company's taxable income.

The Company and its subsidiaries are routinely examined by various U.S. and
non-U.S. taxing authorities. The IRS has completed substantially all of the
examinations of the Company's federal income tax returns through 2015 and is
currently examining certain of the Company's federal income tax returns for 2016
through 2018. In addition, the Company has subsidiaries in Austria, Belgium,
Canada, China, Denmark, France, Germany, India, Japan, Korea, Switzerland, the
United Kingdom and various other countries, states and provinces that are
currently under audit for years ranging from 2004 through 2020.

During the year ended December 31, 2020, the Company settled the IRS audits of
its federal income tax returns for 2012 through 2015. In the audit, the IRS
proposed significant adjustments to the Company's taxable income of
approximately $2.7 billion related to the deferral of tax on certain premium
income related to the Company's self-insurance programs. For income tax
purposes, the recognition of certain premium income has been deferred in
accordance with U.S. tax laws related to insurance. While the settlement of
these matters was not material to the Company's financial statements, the
settlement does not preclude the IRS from proposing similar adjustments in
future audits and the IRS has continued to examine the deferral of premium
income related to self-insurance programs in its examination of the Company's
federal income tax returns for 2016 through 2018. The examination is ongoing and
to date, the IRS has not proposed any adjustments related to the Company's
self-insurance programs. Due to the enactment of the TCJA in 2017 and the
resulting reduction in the U.S. corporate tax rate for years after 2017, the
Company remeasured its deferred tax liabilities related to the temporary
differences associated with this deferred premium income from 35.0% to 21.0%. If
the IRS proposes adjustments related to the Company's self-insurance premiums
with respect to years prior to the adoption of the TCJA and the Company is
unsuccessful in defending its position, any taxes owed to the IRS may be
computed under the previous 35.0% statutory tax rate and the Company may be
required to remeasure the related deferred tax liabilities from 21.0% to 35.0%,
which in addition to any interest due on the amounts assessed, would require a
charge to future earnings. Management believes the positions the Company has
taken in its U.S. tax returns are in accordance with the relevant tax laws.

Tax authorities in Denmark have issued tax assessments related to interest
accrued by certain of the Company's subsidiaries for the years 2004 through
2015. During the first quarter of 2021, the Company received a notice from the
Danish tax authorities that included a significant reduction in the interest
amounts imposed on the original tax assessments. Taking into account the revised
interest amounts, the assessments total approximately DKK 2.1 billion including
interest accrued to date (approximately $317 million based on the exchange rate
as of December 31, 2021). The Company's appeal of the tax assessments with the
Danish National Tax Tribunal has been put on hold awaiting the final outcome of
other preceding withholding tax cases that have been brought before the Danish
High Court. Management believes the positions the Company has taken in Denmark
are

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in accordance with the relevant tax laws and is vigorously defending its
positions. The Company intends on pursuing this matter through the Danish High
Court should the appeal to the Danish National Tax Tribunal be unsuccessful.
While the ultimate resolution of this matter is uncertain and could take many
years, as a result of the payments the Company has previously made related to
these assessments in order to mitigate further interest accruals, the Company
does not expect the resolution of this matter will have a future material
adverse impact to the Company's financial statements, including its cash flow
and effective tax rate.

The Company expects its 2022 effective tax rate to be approximately 20.0% which
is higher than the 2021 rate due primarily to the impact of net discrete tax
benefits on the 2021 effective tax rate and the geographic mix of earnings
anticipated for 2022. Any future legislative changes in the United States and/or
potential tax reform in other jurisdictions, could cause the Company's effective
tax rate to differ from this estimate. Refer to Note 7 to the Consolidated
Financial Statements for additional information related to income taxes.

DISCONTINUED OPERATIONS



On July 2, 2016, the Company completed the separation of its former Test &
Measurement segment, Industrial Technologies segment (excluding the product
identification businesses) and retail/commercial petroleum business by
distributing to Danaher stockholders on a pro rata basis all of the issued and
outstanding common stock of Fortive Corporation ("Fortive"), the entity the
Company incorporated to hold such businesses. In 2021, the Company recorded an
income tax benefit of $86 million related to the release of previously provided
reserves associated with uncertain tax positions on certain of the Company's tax
returns which were jointly filed with Fortive entities. These reserves were
released due to the expiration of statutes of limitations for those returns.
This income tax benefit is included in earnings from discontinued operations,
net of income taxes in the Consolidated Statements of Earnings.

On December 18, 2019, the Company completed its disposition of its remaining
ownership of Envista and as a result, the results of Envista are reported as
discontinued operations.

Refer to Note 3 to the Consolidated Financial Statements for additional information.

COMPREHENSIVE INCOME



Comprehensive income decreased by $572 million in 2021 as compared to 2020,
primarily driven by the impact of losses from foreign currency translation
adjustments in 2021 compared to gains in 2020, partially offset by higher net
earnings and an increase in the income from pension and postretirement plan
benefit adjustments and cash flow hedge adjustments in 2021 compared to 2020.
The Company recorded a foreign currency translation loss of approximately $1.3
billion for 2021 compared to a gain of approximately $2.9 billion for 2020. The
Company recorded a pension and postretirement plan benefit gain of $378 million
for 2021 compared to a loss of $147 million for 2020. The Company recorded gains
from cash flow hedge adjustments related to the Company's derivative contracts
in 2021 of $247 million compared to losses of $72 million in 2020.

FINANCIAL INSTRUMENTS AND RISK MANAGEMENT



The Company is exposed to market risk from changes in interest rates, foreign
currency exchange rates, equity prices and commodity prices as well as credit
risk, each of which could impact its Consolidated Financial Statements. The
Company generally addresses its exposure to these risks through its normal
operating and financing activities. The Company also periodically uses
derivative financial instruments to manage foreign exchange risks and interest
rate risks. In addition, the Company's broad-based business activities help to
reduce the impact that volatility in any particular area or related areas may
have on its financial statements as a whole.

Interest Rate Risk



The Company manages interest cost using a mixture of fixed-rate and
variable-rate debt. A change in interest rates on fixed rate debt impacts the
fair value of the debt but not the Company's earnings or cash flow because the
interest on such debt is fixed. Generally, the fair market value of fixed-rate
debt will increase as interest rates fall and decrease as interest rates rise.
As of December 31, 2021, an increase of 100 basis points in interest rates would
have decreased the fair value of the Company's fixed-rate long-term debt by
approximately $1.7 billion.

As of December 31, 2021, the Company's variable-rate debt obligations consisted
primarily of U.S. dollar and euro-based commercial paper borrowings (refer to
Note 14 to the Consolidated Financial Statements for information regarding the
Company's outstanding commercial paper balances as of December 31, 2021). As a
result, the Company's primary interest rate exposure results from changes in
short-term interest rates. As these shorter duration obligations mature, the
Company may issue additional short-term commercial paper obligations to
refinance all or part of these borrowings, to the extent commercial paper
markets are available. In 2021, the average annual interest rate associated with
the Company's outstanding commercial

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paper borrowings was approximately negative 12 basis points. A hypothetical increase of this average by 100 basis points would have increased the Company's annual interest expense by approximately $20 million.

Refer to "Results of Operations-Interest Costs" for discussion of the Company's cross-currency swap derivative contracts and interest rate swap agreements.

Currency Exchange Rate Risk



The Company faces transactional exchange rate risk from transactions with
customers in countries outside the United States and from intercompany
transactions between affiliates. Transactional exchange rate risk arises from
the purchase and sale of goods and services in currencies other than Danaher's
functional currency or the functional currency of its applicable subsidiary. The
Company also faces translational exchange rate risk related to the translation
of financial statements of its foreign operations into U.S. dollars, Danaher's
functional currency. Costs incurred and sales recorded by subsidiaries operating
outside of the United States are translated into U.S. dollars using exchange
rates effective during the respective period. As a result, the Company is
exposed to movements in the exchange rates of various currencies against the
U.S. dollar. In particular, the Company has more sales in European currencies
than it has expenses in those currencies. Therefore, when European currencies
strengthen or weaken against the U.S. dollar, operating profits are increased or
decreased, respectively. The effect of a change in currency exchange rates on
the Company's net investment in non-U.S. subsidiaries is reflected in the
accumulated other comprehensive income (loss) component of stockholders' equity.

Currency exchange rates positively impacted 2021 reported sales on a
year-over-year basis primarily due to the weakening of the U.S. dollar against
most major currencies during the first nine months of 2021, slightly offset by
the strengthening of the U.S. dollar during the fourth quarter of 2021. If the
currency exchange rates in effect as of December 31, 2021 were to prevail
throughout 2022, currency exchange rates would decrease 2022 estimated sales
relative to 2021 sales by approximately 1.0%. Strengthening of the U.S. dollar
against other major currencies compared to the exchange rates in effect as of
December 31, 2021 would adversely impact the Company's sales and results of
operations on an overall basis. Any weakening of the U.S. dollar against other
major currencies compared to the exchange rates in effect as of December 31,
2021 would positively impact the Company's sales and results of operations.

The Company has generally accepted the exposure to exchange rate movements
without using derivative financial instruments to manage this transactional
exchange risk, although the Company has used foreign currency-denominated debt
and cross-currency swaps to hedge a portion of its net investments in non-U.S.
operations against adverse movements in exchange rates. Both positive and
negative movements in currency exchange rates against the U.S. dollar will
continue to affect the reported amount of sales and net earnings in the
Company's Consolidated Financial Statements. In addition, the Company has assets
and liabilities held in foreign currencies. A 10% depreciation in major
currencies relative to the U.S. dollar as of December 31, 2021 would have
reduced foreign currency-denominated net assets and stockholders' equity by
approximately $1.6 billion. Refer to Note 15 to the Consolidated Financial
Statements for information regarding the Company's hedging of a portion of its
net investment in non-U.S. operations.

Equity Price Risk



The Company's investment portfolio from time to time includes publicly-traded
equity securities that are sensitive to fluctuations in market price. As of
December 31, 2021, the Company held $88 million of publicly-traded equity
securities. Additionally, the Company holds non-marketable equity investments in
privately held companies that may be impacted by equity price risks. These
non-marketable equity investments are accounted for under the Fair Value
Alternative method with changes in fair value recorded in earnings. Volatility
in the equity markets or other fair value considerations could affect the value
of these investments and require charges or gains to be recognized in earnings.

Commodity Price Risk

For a discussion of risks relating to commodity prices, refer to "Item 1A. Risk Factors."



Credit Risk

The Company is exposed to potential credit losses in the event of nonperformance
by counterparties to its financial instruments. Financial instruments that
potentially subject the Company to credit risk consist of cash and temporary
investments, receivables from customers and derivatives. The Company places cash
and temporary investments with various high-quality financial institutions
throughout the world and exposure is limited at any one institution. Although
the Company typically does not obtain collateral or other security to secure
these obligations, it does regularly monitor the third-party depository
institutions that hold its cash and cash equivalents. The Company's emphasis is
primarily on safety and liquidity of principal and secondarily on maximizing
yield on those funds.

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In addition, concentrations of credit risk arising from receivables from
customers are limited due to the diversity of the Company's customers. The
Company's businesses perform credit evaluations of their customers' financial
conditions as deemed appropriate and also obtain collateral or other security
when deemed appropriate.

The Company enters into derivative transactions infrequently and typically with
high-quality financial institutions, so that exposure at any one institution is
limited.

LIQUIDITY AND CAPITAL RESOURCES



Management assesses the Company's liquidity in terms of its ability to generate
cash to fund its operating, investing and financing activities. The Company
continues to generate substantial cash from operating activities and believes
that its operating cash flow, cash on hand and other sources of liquidity will
be sufficient to allow it to continue investing in existing businesses
(including capital expenditures), consummating strategic acquisitions and
investments, paying interest and servicing debt, paying dividends, funding
restructuring activities and managing its capital structure on a short-term and
long-term basis.

The Company has relied primarily on borrowings under its commercial paper
program to address liquidity requirements that exceed the capacity provided by
its operating cash flows and cash on hand, while also accessing the capital
markets from time to time including to secure financing for more significant
acquisitions. Subject to any limitations that may result from the COVID-19
pandemic or other market disruptions (such as the disruptions in the financial
and capital markets that occurred at times in 2020), the Company anticipates
following the same approach in the future.

Following is an overview of the Company's cash flows and liquidity for the years ended December 31:

Overview of Cash Flows and Liquidity



($ in millions)                                            2021               2020               2019
Total operating cash flows provided by continuing
operations                                             $   8,358          $   6,215          $   3,657

Cash paid for acquisitions                             $ (10,961)         $ (20,971)         $    (331)
Payments for additions to property, plant and
equipment                                                 (1,294)              (791)              (636)
Proceeds from sales of property, plant and equipment          13                  2                 13
Payments for purchases of investments                       (934)              (342)              (241)
Proceeds from sales of investments                           126                 13                  -
Proceeds from sale of product lines                           26                826                  -
All other investing activities                                37                 24                 29
Total investing cash used in discontinued operations           -                  -                (72)
Net cash used in investing activities                  $ (12,987)         $ 

(21,239) $ (1,238)



Proceeds from the issuance of common stock in
connection with stock-based compensation               $      86          $ 

153 $ 130 Proceeds from the public offering of common stock, net of issuance costs

                                              -              1,729              1,443

Proceeds from the public offering of preferred stock, net of issuance costs

                                          -              1,668              1,600
Net proceeds from the sale of Envista Holdings
Corporation common stock, net of issuance costs                -                  -                643
Payment of dividends                                        (742)              (615)              (527)

Net proceeds from (repayments of) borrowings
(maturities of 90 days or less)                            2,265             (4,637)             2,802

Proceeds from borrowings (maturities longer than 90 days)

                                                        984              8,670             12,113

Repayments of borrowings (maturities longer than 90 days)

                                                     (1,186)            (5,933)            (1,565)
Make-whole premiums to redeem borrowings prior to
maturity                                                     (96)               (26)                (7)
All other financing activities                               (16)                (3)               (43)

Cash distributions to Envista Holdings Corporation, net

                                                            -                  -               (224)
Net cash provided by financing activities              $   1,295          $ 

1,006 $ 16,365




•Operating cash flows from continuing operations increased approximately $2.1
billion, or 34%, during 2021 as compared to 2020, due primarily to higher net
earnings from continuing operations (after excluding charges for

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depreciation, amortization (including intangible assets and inventory step-up),
stock compensation, gain on sale of product lines, unrealized investment
gains/losses, loss on the extinguishment of debt and the contract settlement
expense in 2021). These increases were partially offset by higher cash used in
aggregate for accounts receivables, inventories, trade accounts payable and
accrued and prepaid expenses in 2021 compared to the prior year.

•Net cash used in investing activities consisted primarily of cash paid for
acquisitions, capital expenditures and investments, net of proceeds from the
sale of investments, and decreased primarily as a result of lower cash paid for
acquisitions in 2021 compared to 2020. Refer to Notes 2 and 12 to the
Consolidated Financial Statements included in this Annual Report for a
discussion of the Company's acquisitions and investments.

•As of December 31, 2021, the Company held approximately $2.6 billion of cash and cash equivalents.



Operating Activities

Cash flows from operating activities can fluctuate significantly from period-to-period as working capital needs and the timing of payments for income taxes, restructuring activities and productivity improvement initiatives, pension funding and other items impact reported cash flows.



Operating cash flows from continuing operations were approximately $8.4 billion
for 2021, an increase of approximately $2.1 billion, or 34%, as compared to
2020. The year-over-year change in operating cash flows from 2020 to 2021 was
primarily attributable to the following factors:

•2021 operating cash flows benefited from higher net earnings in 2021 as compared to 2020.



•Net earnings for 2021 reflected an increase of approximately $679 million of
depreciation, amortization, stock compensation expense, unrealized investment
gains/losses, loss on the extinguishment of debt and contract settlement expense
as compared to 2020. Amortization expense primarily relates to the amortization
of intangible assets and inventory fair value adjustments. Depreciation expense
relates to both the Company's manufacturing and operating facilities as well as
instrumentation leased to customers under operating-type lease arrangements.
Contract settlement expense represents the pretax charge related to the
modification and partial termination of a prior commercial arrangement and
resolution of the associated litigation. Refer to Note 8 to the Consolidated
Financial Statements for additional information on the contract settlement
expense. Depreciation, amortization, stock compensation and contract settlement
expense are noncash expenses that decrease earnings without a corresponding
impact to operating cash flows. Cash flows from the gain on sale of product
lines and loss on the extinguishment of debt are reflected in cash flows from
investing activities while unrealized investment gains/losses impact net
earnings without immediately impacting cash flows as the cash flow impact from
investments occurs when the invested capital is returned to the Company.

•The aggregate of trade accounts receivable, inventories and trade accounts
payable used $564 million in operating cash flows during 2021, compared to $160
million of operating cash flows used in 2020. The amount of cash flow generated
from or used by the aggregate of trade accounts receivable, inventories and
trade accounts payable depends upon how effectively the Company manages the cash
conversion cycle, which effectively represents the number of days that elapse
from the day it pays for the purchase of raw materials and components to the
collection of cash from its customers and can be significantly impacted by the
timing of collections and payments in a period.

•The aggregate of prepaid expenses and other assets, deferred income taxes and
accrued expenses and other liabilities used $94 million in operating cash flows
during 2021, compared to $739 million provided in 2020. The timing of cash
payments for taxes, various employee-related liabilities, customer funding and
accrued expenses drove the majority of this change.

Investing Activities

Cash flows relating to investing activities consist primarily of cash used for acquisitions and capital expenditures, including instruments leased to customers, cash used for investments and cash proceeds from divestitures of businesses or assets.

Net cash used in investing activities was approximately $13.0 billion during 2021 compared to approximately $21.2 billion of net cash used in 2020.

Acquisitions, Divestitures and Sale of Investments



For a discussion of the Company's 2021 and 2020 acquisitions and divestitures
refer to "-Overview" and Note 2 to the Consolidated Financial Statements. In
addition, in 2021 and 2020, the Company invested $934 million and $342 million,
respectively, in non-marketable equity securities and partnerships.

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Capital Expenditures



Capital expenditures are made primarily for increasing manufacturing capacity,
replacing equipment, supporting new product development, improving information
technology systems and the manufacture of instruments that are used in
operating-type lease arrangements that certain of the Company's businesses enter
into with customers. Capital expenditures totaled approximately $1.3 billion in
2021 and $791 million in 2020. The year-over-year increase in capital spending
in 2021 was primarily due to incremental capital expenditures to increase
manufacturing capacity for diagnostic testing and biopharma products (including
to address increased COVID-19 related demand) as well as incremental capital
expenditures as a result of the Cytiva and Aldevron Acquisitions. In 2022, the
Company expects to incur higher capital spending than the prior year to increase
manufacturing capacity primarily to support customer demand for products related
to testing, treatment and vaccine production for COVID-19 and other growth
opportunities. The Company estimates capital expenditures in 2022 to be
approximately $1.5 billion.

During 2021, certain agencies of the U.S. government, including BARDA, agreed to
finance an expansion of production capacity related to chromatography, liquid
cell culture media, buffers and cell culture powder media and single-use
consumables at certain of the Company's Life Sciences businesses and the
development of diagnostics testing technologies and the expansion of testing
production capacity at certain of the Company's Diagnostics businesses. The
Company's businesses may enter into similar agreements in the future. In
consideration of this financing the U.S. government has certain rights,
including rights with respect to the allocation of certain of the incremental
production capacity associated with such expansion and/or rights in intellectual
property produced with its financial assistance. The amount awarded pursuant to
these grants in 2021 totaled $568 million and will be paid over periods ranging
from one to four years. In 2021, the Company received aggregate payments related
to government grants of $73 million that offset operating expenses and capital
expenditures of $41 million and $32 million, respectively.

Financing Activities



Cash flows from financing activities consist primarily of cash flows associated
with the issuance and repayments of commercial paper, issuance and repayment of
long-term debt, borrowings under committed credit facilities, issuance and
repurchases of common stock, issuance of preferred stock and payments of cash
dividends to shareholders. Financing activities provided cash of approximately
$1.3 billion during 2021 compared to approximately $1.0 billion of cash provided
during 2020. The year-over-year increase in cash provided by financing
activities was due primarily to cash provided in 2021 from the issuance of
commercial paper used to fund a portion of the Aldevron Acquisition and the
issuance of debt securities in the fourth quarter of 2021, partially offset by
cash provided by the sale of common and preferred stock and borrowings incurred
in 2020 to finance the remaining amounts needed to acquire Cytiva and for
general corporate purposes, as well as the issuance of debt securities in the
fourth quarter of 2020.

Total debt was approximately $22.2 billion and $21.2 billion as of December 31,
2021 and 2020, respectively, and notes payable and current portion of long-term
debt was $8 million and $11 million as of December 31, 2021 and 2020,
respectively. As of December 31, 2021, the Company had the ability to incur
approximately $2.2 billion of additional indebtedness in direct borrowings or
under the outstanding commercial paper facilities based on the amounts available
under the Company's $5.0 billion Five-Year Facility which were not being used to
backstop outstanding commercial paper balances. As of December 31, 2021, the
Company has classified approximately $2.8 billion of its borrowings outstanding
under the U.S. dollar and euro-denominated commercial paper program, $699
million of borrowings outstanding under the 2022 Biopharma Notes and $284
million of borrowings outstanding under the Floating Rate 2022 Euronotes as
long-term debt in the Consolidated Balance Sheet as the Company has the intent
and ability, as supported by availability under the Five-Year Facility, to
refinance these borrowings for at least one year from the balance sheet date. As
commercial paper obligations mature, the Company may issue additional short-term
commercial paper obligations to refinance all or part of these borrowings, to
the extent commercial paper markets are available.

Under the Company's U.S. dollar and euro-denominated commercial paper program,
the notes are typically issued at a discount from par, generally based on the
ratings assigned to the Company by credit rating agencies at the time of the
issuance and prevailing market rates measured by reference to LIBOR or EURIBOR.
Additionally, the Company's floating rate senior unsecured notes due 2022 pay
interest based upon the three-month EURIBOR plus 0.3%. In July 2017, the head of
the United Kingdom Financial Conduct Authority announced the intent to phase out
the use of LIBOR by the end of 2021. The U.S. Federal Reserve, in conjunction
with the Alternative Reference Rates Committee, a steering committee comprised
of large U.S. financial institutions, is considering replacing U.S.
dollar LIBOR with the Secured Overnight Financing Rate, or SOFR, a new index
calculated by short-term repurchase agreements, backed by Treasury securities.
The Company has evaluated the anticipated impact of the transition from LIBOR
and does not expect the transition to be material to the Company's financial
position. The U.S. dollar LIBOR-based borrowings will be available to the
Company under the Five-Year Facility until 2023, upon the discontinuance of
LIBOR. Prior to the discontinuation of LIBOR, the Company expects to amend the
Five-Year Facility to replace LIBOR with another reference interest rate.

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Refer to Note 14 to the Consolidated Financial Statements for additional information regarding the Company's financing activities and indebtedness, including the Company's outstanding debt as of December 31, 2021, and the Company's commercial paper program and Five-Year Facility.

Common Stock Offering and MCPS Offering

For a description of the 2020 Common Stock and MCPS Series B Offerings, refer to Note 19 to the Consolidated Financial Statements.

Shelf Registration Statement



The Company has filed a "well-known seasoned issuer" shelf registration
statement on Form S-3 with the SEC that registers an indeterminate amount of
debt securities, common stock, preferred stock, warrants, depositary shares,
purchase contracts and units for future issuance. The Company expects to use net
proceeds realized by the Company from future securities sales off this shelf
registration statement for general corporate purposes, including without
limitation repayment or refinancing of debt or other corporate obligations,
acquisitions, capital expenditures, share repurchases, dividends and/or working
capital.

Stock Repurchase Program

Please see Note 19 to the Consolidated Financial Statements for a description of the Company's stock repurchase program.

Dividends



The Company declared a regular quarterly dividend of $0.21 per share of Company
common stock that was paid on January 28, 2022 to holders of record on
December 30, 2021. In addition, the Company declared quarterly cash dividends of
$11.875 per MCPS Series A and $12.50 per MCPS Series B that were paid on January
15, 2022 to holders of record as of December 31, 2021. Aggregate 2021 and 2020
cash payments for dividends on Company common stock were $578 million and $500
million, respectively, and aggregate 2021 and 2020 cash payments for the
dividends on the Company's MCPS were $164 million and $115 million,
respectively. The year-over-year increase in dividend payments in 2021 primarily
relates to dividends paid on the MCPS Series B, which were issued in May 2020,
and an increase in the quarterly dividend rate on common stock effective with
respect to the dividend paid in the second quarter of 2021.

Cash and Cash Requirements



As of December 31, 2021, the Company held approximately $2.6 billion of cash and
cash equivalents that were on deposit with financial institutions or invested in
highly liquid investment-grade debt instruments with a maturity of 90 days or
less with an approximate weighted average annual interest rate of 0.2%. Of the
cash and cash equivalents, $353 million was held within the United States and
approximately $2.2 billion was held outside of the United States. The Company
will continue to have cash requirements to support general corporate purposes,
which may include working capital needs, capital expenditures, acquisitions and
investments, paying interest and servicing debt, paying taxes and any related
interest or penalties, funding its restructuring activities and pension plans as
required, paying dividends to shareholders, repurchasing shares of the Company's
common stock and supporting other business needs.

The Company generally intends to use available cash and internally generated
funds to meet these cash requirements, but in the event that additional
liquidity is required, the Company may also borrow under its commercial paper
programs (if available) or borrow under the Company's Five-Year Facility, enter
into new credit facilities and either borrow directly thereunder or use such
credit facilities to backstop additional borrowing capacity under its commercial
paper programs (if available) and/or access the capital markets. The Company
also may from time to time seek to access the capital markets to take advantage
of favorable interest rate environments or other market conditions.

While repatriation of some cash held outside the United States may be restricted
by local laws, most of the Company's foreign cash could be repatriated to the
United States. Following enactment of the TCJA and the associated Transition
Tax, in general, repatriation of cash to the United States can be completed with
no incremental U.S. tax; however, repatriation of cash could subject the Company
to non-U.S. taxes on distributions. The cash that the Company's non-U.S.
subsidiaries hold for indefinite reinvestment is generally used to finance
non-U.S. operations and investments, including acquisitions. The income taxes,
if any, applicable to such earnings including basis differences in our non-U.S.
subsidiaries are not readily determinable. As of December 31, 2021, management
believes that it has sufficient sources of liquidity to satisfy its cash needs,
including its cash needs in the United States.

During 2021, the Company contributed $10 million to its U.S. defined benefit
pension plans and $50 million to its non-U.S. defined benefit pension plans.
During 2022, the Company's cash contribution requirements for its U.S. and its
non-U.S. defined benefit pension plans are forecasted to be approximately $10
million and $48 million, respectively. The ultimate amounts to be contributed
depend upon, among other things, legal requirements, underlying asset returns,
the plan's funded status, the anticipated tax deductibility of the contribution,
local practices, market conditions, interest rates and other factors.

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Contractual and Other Obligations

For a description of the Company's debt and lease obligations, commitments, and litigation and contingencies, refer to Notes 10, 14, 17 and 18 to the Consolidated Financial Statements.

Legal Proceedings

Refer to Note 18 to the Consolidated Financial Statements for information regarding legal proceedings and contingencies, and for a discussion of risks related to legal proceedings and contingencies, refer to "Item 1A. Risk Factors."

CRITICAL ACCOUNTING ESTIMATES



Management's discussion and analysis of the Company's financial condition and
results of operations is based upon the Company's Consolidated Financial
Statements, which have been prepared in accordance with accounting principles
generally accepted in the United States. The preparation of these financial
statements requires management to make estimates and judgments that affect the
reported amounts of assets, liabilities, revenues and expenses, and related
disclosure of contingent assets and liabilities. The Company bases these
estimates and judgments on historical experience, the current economic
environment and on various other assumptions that are believed to be reasonable
under the circumstances. Actual results may differ materially from these
estimates and judgments.

The Company believes the following accounting estimates are most critical to an
understanding of its financial statements. Estimates are considered to be
critical if they meet both of the following criteria: (1) the estimate requires
assumptions about material matters that are uncertain at the time the estimate
is made, and (2) material changes in the estimate are reasonably likely from
period-to-period. For a detailed discussion on the application of these and
other accounting estimates, refer to Note 1 to the Consolidated Financial
Statements.

Acquired Intangibles-The Company's business acquisitions, including the Cytiva
and Aldevron acquisitions, typically result in the recognition of goodwill,
developed technology and other intangible assets, which affect the amount of
future period amortization expense and possible impairment charges that the
Company may incur. The fair values of acquired intangibles are determined using
information available near the acquisition date based on estimates and
assumptions that are deemed reasonable by the Company. Significant assumptions
include the discount rates and certain assumptions that form the basis of the
forecasted results of the acquired business including earnings before interest,
taxes, depreciation and amortization ("EBITDA"), revenue, revenue growth rates,
royalty rates and technology obsolescence rates. These assumptions are forward
looking and could be affected by future economic and market conditions. The
Company engages third-party valuation specialists who review the Company's
critical assumptions and calculations of the fair value of acquired intangible
assets in connection with significant acquisitions. In connection with
acquisitions during the year ended December 31, 2021, the Company recognized
aggregate goodwill of approximately $7.2 billion and intangible assets of
approximately $4.0 billion. Refer to Notes 1, 2 and 11 to the Consolidated
Financial Statements for a description of the Company's policies relating to
goodwill, acquired intangibles and acquisitions.

In performing its goodwill impairment testing, the Company estimates the fair
value of its reporting units primarily using a market-based approach which
relies on current trading multiples of forecasted EBITDA for companies operating
in businesses similar to each of the Company's reporting units to calculate an
estimated fair value of each reporting unit. In evaluating the estimates derived
by the market-based approach, management makes judgments about the relevance and
reliability of the multiples by considering factors unique to its reporting
units, including operating results, business plans, economic projections,
anticipated future cash flows, and transactions and marketplace data as well as
judgments about the comparability of the market proxies selected. There are
inherent uncertainties related to these assumptions and management's judgment in
applying them to the analysis of goodwill impairment.

As of December 31, 2021, the Company had five reporting units for goodwill
impairment testing. Reporting units resulting from recent acquisitions generally
present the highest risk of impairment. Management believes the impairment risk
associated with these reporting units generally decreases as these businesses
are integrated into the Company and better positioned for potential future
earnings growth. The Company's annual goodwill impairment analysis in 2021
indicated that in all instances, the fair values of the Company's reporting
units exceeded their carrying values and consequently did not result in an
impairment charge. The excess of the estimated fair value over carrying value
(expressed as a percentage of carrying value for the respective reporting unit)
for each of the Company's reporting units as of the annual testing date ranged
from approximately 175% to approximately 1,200%. To evaluate the sensitivity of
the fair value calculations used in the goodwill impairment test, the Company
applied a hypothetical 10% decrease to the fair values of each reporting unit
and compared those hypothetical values to the reporting unit carrying values.
Based on this hypothetical 10% decrease, the excess of the estimated fair value

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over carrying value (expressed as a percentage of carrying value for the respective reporting unit) for each of the Company's reporting units ranged from approximately 145% to approximately 1,100%.



The Company reviews identified intangible assets for impairment whenever events
or changes in circumstances indicate that the related carrying amounts may not
be recoverable. Determining whether an impairment loss occurred for finite-lived
intangibles requires a comparison of the carrying amount to the sum of
undiscounted cash flows expected to be generated by the asset. These analyses
require management to make judgments and estimates about future revenues,
expenses, market conditions and discount rates related to these assets.
Indefinite-lived intangibles are subject to impairment testing at least annually
or more frequently if events or changes in circumstances indicate that potential
impairment exists. Determining whether an impairment loss occurred for
indefinite-lived intangible assets involves calculating the fair value of the
indefinite-lived intangible assets and comparing the fair value to their
carrying value. If the fair value is less than the carrying value, the
difference is recorded as an impairment loss. Refer to Note 11 to the
Consolidated Financial Statements for a description of intangible assets
impairment charges recorded during 2021.

If actual results are not consistent with management's estimates and
assumptions, goodwill and other intangible assets may be overstated and a charge
would need to be taken against net earnings which would adversely affect the
Company's financial statements. Historically, the Company's estimates of
goodwill and intangible assets have been materially correct.

Contingent Liabilities-As discussed in "Item 3. Legal Proceedings" and Notes 8
and 18 to the Consolidated Financial Statements, the Company is, from time to
time, subject to a variety of litigation and similar contingent liabilities
incidental to its business (or the business operations of previously owned
entities). The Company recognizes a liability for any legal contingency or
contract settlement expense that is known or probable of occurrence and
reasonably estimable. These assessments require judgments concerning matters
such as litigation developments and outcomes, the anticipated outcome of
negotiations, the number of future claims, the cost of both pending and future
claims and the value of the elements in the outcome. In addition, because most
contingencies are resolved over long periods of time, liabilities may change in
the future due to various factors, including those discussed in Note 18 to the
Consolidated Financial Statements. If the reserves established by the Company
with respect to these contingent liabilities are inadequate, the Company would
be required to incur an expense equal to the amount of the loss incurred in
excess of the reserves, which would adversely affect the Company's financial
statements.

Income Taxes-For a description of the Company's income tax accounting policies,
refer to Notes 1 and 7 to the Consolidated Financial Statements. The Company
establishes valuation allowances for its deferred tax assets if it is more
likely than not that some or all of the deferred tax asset will not be realized.
This requires management to make judgments and estimates regarding: (1) the
timing and amount of the reversal of taxable temporary differences, (2) expected
future taxable income, and (3) the impact of tax planning strategies. Future
changes to tax rates would also impact the amounts of deferred tax assets and
liabilities and could have an adverse impact on the Company's financial
statements.

The Company provides for unrecognized tax benefits when, based upon the
technical merits, it is "more likely than not" that an uncertain tax position
will not be sustained upon examination. Judgment is required in evaluating tax
positions and determining income tax provisions. The Company re-evaluates the
technical merits of its tax positions and may recognize an uncertain tax benefit
in certain circumstances, including when: (1) a tax audit is completed; (2)
applicable tax laws change, including a tax case ruling or legislative guidance;
or (3) the applicable statute of limitations expires.

In addition, certain of the Company's tax returns are currently under review by
tax authorities including in Denmark and the United States (refer to "-Results
of Operations-Income Taxes" and Note 7 to the Consolidated Financial
Statements). Management believes the positions taken in these returns are in
accordance with the relevant tax laws. However, the outcome of these audits is
uncertain and could result in the Company being required to record charges for
prior year tax obligations which could have a material adverse impact to the
Company's financial statements, including its effective tax rate.

An increase of 1.0% in the Company's 2021 nominal tax rate would have resulted
in an additional income tax provision for continuing operations for the year
ended December 31, 2021 of $76 million.

Valuation of Investments in Equity Securities-For a description of the Company's
investments in equity securities and partnerships refer to Notes 1, 9 and 12 to
the Consolidated Financial Statements. The Company invests in publicly-traded
securities, non-marketable securities of early-stage companies and equity method
investments, including partnerships that invest primarily in early-stage
companies.

Investments in early-stage companies have significant risks, including
uncertainty regarding the investee company's ability to successfully develop new
technologies and services, bring these new technologies and services to market
and gain market acceptance, maintain adequate capitalization and access to cash
or other forms of liquidity, and retain critical management personnel. Refer to
"Item 1A. Risk Factors" for a further discussion of the risks related to
investing in early-stage companies.

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The Company's investments in publicly traded securities are measured at fair
value based on quotes in active markets. For investments in non-marketable
equity securities where the Company does not have influence over the investee,
the Company has elected the measurement alternative and records these
investments at cost and adjusts the carrying value for impairments and
observable price changes with a same or similar security from the same issuer
adjusted to reflect the specific rights and preferences of the securities, if
applicable. Valuations of non-marketable equity securities are complex and
require judgment due to the absence of market prices, lack of liquidity and the
risks inherent in early-stage companies. The uncertainty in the process of
valuing securities for which a ready market does not exist may cause our
estimated values of these securities to differ significantly from the values
that would have been derived had a ready market for the securities existed, and
those differences could be material.

The Company accounts for its investments in the partnerships using the equity
method. Accordingly, the investments are initially recorded at cost and adjusted
each period for the Company's share of the partnership's income or loss and
distributions received. The partnerships' investments are recorded by the
partnerships on an estimated fair value basis and pose the same risks and
require the same valuation judgments discussed above. As a result, changes in
the value of investments in the partnership will have a direct impact on the
Company's earnings. Impairment losses are recognized to reduce the investment's
carrying value to its fair value if there is a decline in fair value below
carrying value that is considered to be other-than-temporary. To determine
whether there is an other-than-temporary impairment, the Company uses
qualitative and quantitative valuation methods.

Realized and unrealized gains (losses) for these investments in equity
securities and partnerships are recorded in other income (expense), net, in the
Consolidated Statements of Earnings. A 10% decrease in the carrying value of the
Company's investments in equity securities and partnerships as of December 31,
2021 would result in a loss of approximately $160 million.

NEW ACCOUNTING STANDARDS

For a discussion of the new accounting standards impacting the Company, refer to Note 1 to the Consolidated Financial Statements.

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