On April 1, 2022, the Board of Directors of Evelo Biosciences, Inc. appointed Jose-Carlos Gutiérrez-Ramos, Ph.D., as a Class I director on the Board, effective immediately, to serve until the Company's annual meeting of stockholders to be held in 2022 and until his successor is duly elected and qualified or his earlier death, disqualification, resignation or removal. Dr. Gutiérrez-Ramos also was appointed as a member of the Science and Technology Committee of the Board. Dr. Gutiérrez-Ramos previously served on the Board from June 2019 to February 2020.

Since January 2021, Dr. Gutiérrez-Ramos has served as the Chief Science Officer at Danaher Corporation. Also on April 1, 2022, the Board appointed Tonya Williams as a Class III director on the Board, effective immediately, to serve until the Company's annual meeting of stockholders to be held in 2024 and until her successor is duly elected and qualified or her earlier death, disqualification, resignation or removal. Ms. Williams also was appointed as a member of the Nominating and Corporate Governance Committee (the “Governance Committee”) of the Board.

Since January 2019, Ms. Williams has served as Head of External Affairs and Corporate Responsibility at SoftBank Group International, an investment management and financial services firm. Ms. Williams is also currently an Adjunct Professor at the University of Pennsylvania and an advisor to Hangar Management LLC.