PROBI AB Randomized, double blind, placebo-controlled clinical study published. The trial showed significant reduction in the pro-inflammatory markers fractalkine and CD163.
Maintaining or improving mental health and function is of growing interest for many people, and the number of chronically stressed people is increasing dramatically. Mental health is an area which is addressed by the
Probiotics may play a role for psychological function, as the intestine and the brain are connected via the gut-brain axis. Furthermore, the intestinal microbiota influences the immune activation and signaling molecules that are involved in the stress response.
During acute stress the immune system is activated, leading to an imbalance between inflammatory and anti-inflammatory responses. In chronic stress this imbalance and resulting low-grade inflammation may lead to development of diversified stress-related diseases such as cardiovascular diseases, neurodegenerative diseases and cancer.
"The aim of the study was to investigate if intake of the probiotic strain Lactiplantibacillus plantarum, HEAL9[TM] could counteract elevated cortisol and inflammation levels in subjects with chronic stress that are exposed to an acute stress test", explains
"We are pleased with the clinical results showing that intake of Lactiplantibacillus plantarum, HEAL9[TM] resulted in significantly decreased plasma levels of the two inflammatory markers (soluble fractalkine and CD163) compared to placebo - these markers are coupled to acute stress in chronically stressed individuals", Niskanen concludes. It is, to our knowledge, the first time it has been shown that acute mental stress triggers the immediate release of soluble fractalkine but also that a probiotic intervention can reduce the release and thereby potentially mitigate the negative physiological side effects of stress.
Tom Rönnlund, CEO at
The clinical trial, published in Physiology & Behavior, can be found here (https://doi.org/10.1016/j.physbeh.2020.113083).
FOR FURTHER INFORMATION, CONTACT:
Tom Rönnlund, CEO, Probi[®], tel +46 46 286 89 40, e-mail: trd@probi.com
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* Reference: https://www.who.int/mental_health/evidence/en/Note: Lactiplantibacillus plantarum was formerly named Lactobacillus plantarum, prior to the taxonomic reclassification.
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