InnoGI Technologies announced an exciting, market-driven collaboration with Simulations Plus to combine its TIM Technology, part of the InnoGI SurroGUT platform, with the GastroPlus and ADMET Predictor modelling software offered by Simulations Plus. Understanding drug behavior following oral administration is important because solubility and absorption profiles affect dosing and efficacy. However, dynamic interactions between sparingly-soluble active pharmaceutical ingredients, excipients and the gastrointestinal (GI) environment are oversimplified in all static in vitro dissolution models and are very difficult to model using purely computational (in silico) approaches.

To address these challenges and reshape industry norms, leverage unique combination of advanced in vitro dynamic dissolution testing with the TIM Technology, accurately mimicking the physiological conditions of the human GI tract, and the GastroPlus and ADMET Predictor software to deliver cutting-edge predictive models. InnoGI Technologies is offering GastroPlus PBPK modelling of oral drug performance in vivo as a standalone service, with the option to integrate in vitro release or dissolution data for a more holistic formulation-oriented approach using advanced TIM Technology or standard U.S. Pharmacopeia (USP) apparatus, and for the development of strong IVIVCs.