Simulations Plus, Inc. announced the release of GastroPlus 9.9, the latest version of its physiologically based pharmacokinetics/biopharmaceutics (PBPK/PBBM) modeling and simulation software. Key enhancements include: Expanded the ocular (OCAT), oral cavity (OCCAT), and dermal (TCAT) models by adding new formulation and PK/PD mechanisms to better capture local and systemic exposure levels in animals and humans Extended the ACAT model to enhance the evaluation of formulation approaches for local gastrointestinal (GI) disease states Improved Biologics Module features to mimic study designs and refine dose optimization simulations for clinical trial success Upgraded with ADMET Predictor version 11 models, enhancing the company's First in Human Simulator. GastroPlus 9.9 is available now for licensing and download.