Shire : Form 8.5 (EPT/RI)- Shire plc AMENDMENT

AMENDMENT

INCREASED EQUITY SALES BY 1,293 TO 460,315

ADDED EQUITY SWAP PURCHASES OF 1,293

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:	J.P. Morgan Securities Plc
(b) Name of offeror/offeree in relation to whose relevant securities this form relates: Use a separate form for each offeror/offeree	Shire plc
(c) Name of the party to the offer with which exempt principal trader is connected:	Joint Financial Adviser to Takeda Pharmaceutical Company Limited
(d) Date dealing undertaken:	09 November 2018
(e) In addition to the company in 1(b) above, is the exempt principal trader making disclosures in respect of any other party to this offer? If it is a cash offer or possible cash offer, state 'N/A'	Yes, Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security	Purchases/ sales	Total number of securities	Highest price per unit paid/received (GBP)	Lowest price per unit paid/received (GBP)
Ordinary Shares	Purchases Sales	383,731 460,315	46.3350 46.3533	45.4900 45.3821

(b) Cash-settled derivative transactions

Class of relevant security	Product description e.g. CFD	Nature of dealing e.g. opening/closing a long/short position, increasing/reducing a long/short position	Number of reference securities	Price per unit
Ordinary Shares	Equity Swaps	Long Short	22,500 22,500 78 304 477 2,940 28 2,739 151 396 70 22,500 68 232 9,103 51,758 18,468 13,503 16,666 474 1,293 4,882 3,090 1,102 149 435 168 234 9,052 9,644 2,649 1,650 1,647 19,208 300 622 3,576 117 358 182 33,889 785 12,499	45.6062 GBP 45.7811 GBP 45.7923 GBP 45.8632 GBP 45.8795 GBP 45.8833 GBP 45.8954 GBP 45.9207 GBP 45.9444 GBP 45.9474 GBP 45.9586 GBP 45.9612 GBP 45.9722 GBP 45.9908 GBP 45.9978 GBP 46.1226 GBP 46.1229 GBP 46.1241 GBP 46.1250 GBP 46.3520 GBP 59.5798 USD 45.6900 GBP 45.7087 GBP 45.7465 GBP 45.7521 GBP 45.7562 GBP 45.7571 GBP 45.7667 GBP 45.7963 GBP 45.7990 GBP 45.8057 GBP 45.8115 GBP 45.8154 GBP 45.8206 GBP 45.8323 GBP 45.8917 GBP 45.9008 GBP 45.9205 GBP 45.9206 GBP 46.0563 GBP 46.1101 GBP 46.1250 GBP 46.1342 GBP

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security	Product description e.g. call option	Writing, purchasing, selling, varying etc.	Number of securities to which option relates	Exercise price per unit (GBP)	Type e.g. American, European etc.	Expiry date	Option money paid/ received per unit (GBP)

(ii) Exercise

Class of relevant security	Product description e.g. call option	Exercising/ exercised against	Number of securities	Exercise price per unit (GBP)

(d) Other dealings (including subscribing for new securities)

Class of relevant security	Nature of dealing e.g. subscription, conversion	Details	Price per unit (if applicable) (GBP)

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer: Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to: (i) the voting rights of any relevant securities under any option; or (ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced: If there are no such agreements, arrangements or understandings, state 'none'

None

Date of disclosure:	14 November 2018
Contact name:	Alwyn Basch
Telephone number:	020 7742 7407

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on [phone].

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.