Forward-looking statements



Certain information and statements included in this quarterly report on
Form 10-Q, including, without limitation, statements containing the words
"forecast," "guidance," "projects," "estimates," "anticipates," "goals,"
"believes," "expects," "intends," "may," "plans," "seeks," "should," or
"targets," "will," or the negative of those words or similar words, constitute
"forward-looking statements" within the meaning of Section 27A of the Securities
Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934,
as amended. Forward-looking statements involve inherent risks and uncertainties
regarding events, conditions, and financial trends that may affect our future
plans of operations, business strategy, results of operations, and financial
position. A number of important factors could cause actual results to differ
materially from those included within or contemplated by the forward-looking
statements, including, but not limited to, the following:

•Operating factors such as a failure to operate our business successfully in
comparison to market expectations or in comparison to our competitors, our
inability to obtain capital when desired or refinance debt maturities when
desired, and/or a failure to maintain our status as a REIT for federal tax
purposes.
•Market and industry factors such as adverse developments concerning the life
science, agtech, and technology industries and/or our tenants.
•Government factors such as any unfavorable effects resulting from federal,
state, local, and/or foreign government policies, laws, and/or funding levels.
•Global factors such as negative economic, political, financial, credit market,
and/or banking conditions.
•Uncertain global, national, and local impacts of the ongoing COVID-19 pandemic.
•Other factors such as climate change, cyber intrusions, and/or changes in laws,
regulations, and financial accounting standards.

This list of risks and uncertainties is not exhaustive. Additional information
regarding risk factors that may affect us is included under "Item 1A. Risk
factors" and "Item 7. Management's discussion and analysis of financial
condition and results of operations" of our annual report on Form 10-K for the
year ended December 31, 2020, and respective sections within this quarterly
report on Form 10-Q. Readers of this quarterly report on Form 10-Q should also
read our other documents filed publicly with the SEC for further discussion
regarding such factors.


                                       44
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The COVID-19 pandemic



In December 2019, a novel coronavirus, which causes respiratory illness and
spreads from person to person (COVID-19), was identified for the first time. The
first case of COVID-19 in the U.S. was reported on January 20, 2020. On
March 11, 2020, the World Health Organization declared COVID-19 a global
pandemic, and on March 13, 2020, the U.S. declared a national emergency with
respect to COVID-19.

COVID-19 prevention, treatment, and other measures to combat the pandemic



Since scientists shared the virus's genetic makeup in January 2020, intense
research has been underway around the world to develop treatments and vaccines
for COVID-19. This has led to the U.S. Food and Drug Administration ("FDA")
issuing Emergency Use Authorizations ("EUAs") for therapeutics to treat patients
with COVID-19 and, most recently, issuing EUAs for three vaccines for use in the
prevention of coronavirus disease caused by COVID-19.

The three vaccines issued EUAs were created by Pfizer Inc. (in partnership with
BioNTech), Moderna, Inc. (in partnership with the National Institutes of Health
("NIH")), and Johnson & Johnson, each a tenant of ours. The U.S. began a
large-scale COVID-19 vaccination campaign in December 2020. As of July 23, 2021,
according to the U.S. Centers for Disease Control and Prevention, approximately
162.4 million individuals in the U.S. have been fully vaccinated for COVID-19,
and the U.S. will continue to roll out vaccines across the nation. The U.S. has
sufficient vaccine supply to inoculate 100% of the population for which the
vaccines are authorized and continues to facilitate access and encourage the
remaining unvaccinated population to get vaccinated so the country may achieve
herd immunity.

Access to vaccines outside the U.S. remains limited, and as a result, new
strains of COVID-19 continue to emerge. The level of resistance these new
strains may have to the existing vaccines remains unknown and is being closely
tracked by governments in partnership with industry. The effectiveness and
durability of current vaccines to emerging variants will help determine the need
for boosters in the future.

Impact to the global and U.S. economy

As a result of the unprecedented measures taken in the U.S. and around the world, the disruption and impact to the U.S. and global economies and financial markets by the COVID-19 pandemic have been significant.



Based on the data provided by the U.S. Bureau of Labor Statistics on July 2,
2021, the unemployment rate in the U.S. is up by 2.4% since February 2020 to
5.9%. While still higher compared to pre-pandemic levels, there has been a
slight decrease since December 2020. The July 2021 data reported an increase of
approximately 850,000 jobs in June 2021, reflecting the gradual reopening of the
economy as a result of vaccine distribution.

Since March 2020, the U.S. government has passed approximately $5.3 trillion in
government funding to combat the pandemic and stimulate the economy. The various
relief packages provided unemployment benefits, direct payments to all eligible
Americans, small business loans, funding toward highly impacted industries and
funding toward the U.S. health system to fund research, construction, and
acquisition of equipment for vaccine and infectious disease research facilities,
as well as the distribution of vaccines.

It is too early to determine the full, long-term economic impact of the COVID-19
pandemic and corresponding government stimulus measures. Potential
ineffectiveness of relief measures could lead to the deterioration of economic
conditions, significant inflation, long-term high unemployment rates, and/or a
recession, which in turn could materially affect our (or our tenants' or venture
investment portfolio companies') performance, financial condition, results of
operations, and cash flows.

See "Item 1A. Risk factors" in our most recent annual report on Form 10-K for
additional discussion of the risks posed by the COVID-19 pandemic and
uncertainties we, our tenants, and the national and global economies may face as
a result.


                                       45

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Overview



We are a Maryland corporation formed in October 1994 that has elected to be
taxed as a REIT for federal income tax purposes. We are an S&P 500® urban office
REIT and the first, longest-tenured, and pioneering owner, operator, and
developer uniquely focused on collaborative life science, agtech, and technology
campuses in AAA innovation cluster locations, with a total market capitalization
of $36.3 billion and an asset base in North America of 58.1 million SF as of
June 30, 2021. The asset base in North America includes 36.7 million RSF of
operating properties and 3.4 million RSF of Class A properties undergoing
construction, 7.7 million RSF of near-term and intermediate-term development and
redevelopment projects, and 10.3 million SF of future development projects.
Founded in 1994, we pioneered this niche and have since established a
significant market presence in key locations, including Greater Boston, the San
Francisco Bay Area, New York City, San Diego, Seattle, Maryland, and Research
Triangle. We have a longstanding and proven track record of developing Class A
properties clustered in urban life science, agtech, and technology campuses that
provide our innovative tenants with highly dynamic and collaborative
environments that enhance their ability to successfully recruit and retain
world-class talent and inspire productivity, efficiency, creativity, and
success. Alexandria also provides strategic capital to transformative life
science, agtech, and technology companies through our venture capital platform.
We believe these advantages result in higher occupancy levels, longer lease
terms, higher rental income, higher returns, and greater long-term asset value.

As of June 30, 2021:



•Investment-grade or publicly traded large cap tenants represented 53% of our
total annual rental revenue;
•Approximately 95% of our leases (on an RSF basis) contained effective annual
rent escalations that were either fixed (generally ranging from approximately
3.0% to 3.5%) or indexed based on a consumer price index or other index;
•Approximately 94% of our leases (on an RSF basis) were triple net leases, which
require tenants to pay substantially all real estate taxes, insurance,
utilities, repairs and maintenance, common area expenses, and other operating
expenses (including increases thereto) in addition to base rent; and
•Approximately 94% of our leases (on an RSF basis) provided for the recapture of
capital expenditures (such as heating, ventilation, and air conditioning systems
maintenance and/or replacement, roof replacement, and parking lot resurfacing)
that we believe would typically be borne by the landlord in traditional office
leases.

Our primary business objective is to maximize stockholder value by providing our
stockholders with the greatest possible total return and long-term asset value
based on a multifaceted platform of internal and external growth. A key element
of our strategy is our unique focus on Class A properties clustered in urban
campuses. These key urban campus locations are characterized by high barriers to
entry for new landlords, high barriers to exit for tenants, and a limited supply
of available space. They generally represent highly desirable locations for
tenancy by life science, agtech, and technology entities because of their close
proximity to concentrations of specialized skills, knowledge, institutions, and
related businesses. Our strategy also includes drawing upon our deep and broad
real estate, life science, agtech, and technology relationships in order to
identify and attract new and leading tenants and to source additional
value-creation real estate.

                                       46
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Executive summary

Operating results


                                          Three Months Ended June 30,       

Six Months Ended June 30,


                                           2021                  2020                  2021                 2020

Net income attributable to Alexandria's common stockholders - diluted: In millions

$        380.6          $    226.6          $       388.5          $    244.8
Per share                            $         2.61          $     1.82          $        2.74          $     1.99
Funds from operations attributable to Alexandria's common stockholders - diluted, as adjusted:
In millions                          $        282.3          $    225.0          $       545.2          $    446.4
Per share                            $         1.93          $     1.81          $        3.84          $     3.63

The operating results shown above include certain items related to corporate-level investing and financing decisions. Refer to the tabular presentation of these items at the beginning of the "Results of operations" section within this Item 2 for additional information.

Six-time Nareit Investor CARE Gold Award winner



2021 recipient of the Nareit Investor CARE (Communications and Reporting
Excellence) Gold Award in the Large Cap Equity REIT category as the
best-in-class REIT delivering transparency, quality, and efficient
communications and reporting to the investment community. This represents our
fourth consecutive Nareit Investor CARE Gold Award, and our sixth Gold Award
over the last seven years.

Historic leasing activity and rental rate growth; continued strong net operating income and internal growth



•During the three months ended June 30, 2021, historic demand for our
high-quality office/laboratory space translated into 1.9 million RSF of leasing
activity, representing the highest leasing activity in a single quarter and the
second highest rental rate growth in Company history.
•Continued strong leasing activity and rental rate growth during the three and
six months ended June 30, 2021, over expiring rates on renewed and re-leased
space:
                                                                                      June 30, 2021
                                                             Three Months Ended                            Six Months Ended
Total leasing activity - RSF                                       1,933,838                                    3,611,497
Leasing of development and redevelopment space -
RSF                                                                  256,328                                    1,045,301
Lease renewals and re-leasing of space:
RSF (included in total leasing activity above)                     1,472,713                                    1,994,538
Rental rate increases                                                          42.4%                                        40.7%
Rental rate increases (cash basis)                                             25.4%                                        23.3%



•Total revenues:
•$509.6 million, up 16.6%, for the three months ended June 30, 2021, compared to
$437.0 million for the three months ended June 30, 2020.
•$989.5 million, up 12.8%, for the six months ended June 30, 2021, compared to
$876.9 million for the six months ended June 30, 2020.
•Net operating income (cash basis) of $1.3 billion for the three months ended
June 30, 2021, annualized, increased by $194.4 million, or 17.6%, compared to
the three months ended June 30, 2020, annualized.
•95% of our leases contain contractual annual rent escalations approximating 3%.
•Same property net operating income growth:
•3.7% and 7.8% (cash basis) for the three months ended June 30, 2021, over the
three months ended June 30, 2020.
•4.4% and 7.4% (cash basis) for the six months ended June 30, 2021, over the six
months ended June 30, 2020.

                                       47
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A REIT industry-leading high-quality tenant roster with high-quality revenues and cash flows, strong margins, and operational excellence

Percentage of annual rental revenue in effect from investment-grade or publicly traded large cap tenants

                                                            53  %

Occupancy of operating properties in North America                                         94.3  % (1)
Operating margin                                                                             72  %
Adjusted EBITDA margin                                                                       69  %
Weighted-average remaining lease term:
All tenants                                                                                    7.5 years
Top 20 tenants                                                                                11.1 years


(1)Includes 1.4 million RSF, or 3.8%, of vacancy at recently acquired properties
in our North America markets, representing lease-up opportunities that are
expected to provide incremental annual rental revenues in excess of $55 million.
Approximately 35% of the vacant 1.4 million RSF is currently under
leased/negotiating, with occupancy expected primarily over the next two
quarters. Excluding these acquired vacancies, occupancy of operating properties
in North America was 98.1% as of June 30, 2021. Refer to the "Summary of
occupancy percentages in North America" section within this Item 2 for
additional information regarding vacancy at recently acquired properties.

Strong and flexible balance sheet with significant liquidity



•Investment-grade credit ratings ranked in the top 10% among all publicly traded
U.S. REITs as of June 30, 2021.
•Net debt and preferred stock to Adjusted EBITDA of 5.8x and fixed-charge
coverage ratio of 4.9x for the three months ended June 30, 2021, annualized.
•$4.5 billion of liquidity as of June 30, 2021.

Continued dividend strategy to share growth in cash flows with stockholders



Common stock dividend declared for the three months ended June 30, 2021, of
$1.12 per common share, aggregating $4.36 per common share for the twelve months
ended June 30, 2021, up 24 cents, or 6%, over the twelve months ended June 30,
2020. Our FFO payout ratio of 60% for the three months ended June 30, 2021,
allows us to continue to share growth in cash flows from operating activities
with our stockholders while also retaining a significant portion for
reinvestment.

Sustained strength in tenant collections



•Tenant collections remain consistently high, with 99.4% of July 2021 billings
collected as of the date of this report.
•As of June 30, 2021, our tenant receivables balance was $6.7 million,
representing our lowest balance since 2012.

Leasing activity of development and redevelopment projects



We continue to execute our unique and differentiated life science strategy at an
accelerated pace and expand our collaborative campuses and asset base in each of
our key life science cluster submarkets, and we remain strategically positioned
to take maximum advantage of historic tenant demand. Demand for our
value-creation development and redevelopment projects of high-quality
office/laboratory space, as well as continued operational excellence at our
world-class, sophisticated laboratory facilities and strong execution by our
team, has translated into record leasing activity. The following table provides
leasing activity of our development and redevelopment projects:

                      Leased RSF                            In-Process RSF(1)
     2020              Six months ended June 30, 2021      As of July 26, 2021
 1.0 million                    1.0 million                    3.0 million


(1)  Represents in-process leasing activity on near-term value-creation
development and redevelopment projects that are expected to commence vertical
construction in 2021/2022. Includes 2.2 million RSF related to leases under
negotiation/executed letters of intent and 0.8 million RSF related to letters of
intent under negotiation.

Value-creation development and redevelopment projects are expected to generate significant growth in rental revenues and cash flows



                                  Projects Expected to Commence            Incremental Projected
    Under Construction              Construction in 2021/2022              Annual Rental Revenues

     3.4 million RSF                     3.6 million RSF
      33 Properties         +             19 Properties             =          >$545 million
  80% Leased/Negotiating              89% Leased/Negotiating


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Delivery of fully leased value-creation projects



•During the three months ended June 30, 2021, we placed into service development
and redevelopment projects aggregating 755,565 RSF that are 100% leased across
five submarkets.
•Annual net operating income (cash basis) is expected to increase by $49 million
upon the burn-off of initial free rent from recently delivered projects.

Alexandria at the vanguard of innovation for over 750 tenants and looking to accommodate current needs plus a path for future growth



•In June 2021, we entered into a definitive agreement to expand our Alexandria
Center® at Kendall Square campus through our acquisition of a 100% interest in
One Rogers Street and One Charles Park for a purchase price of $815.0 million.
This acquisition provides a key expansion to our mega campus strategy in our
Cambridge submarket, the premier life science real estate market in the world,
and consists of the following:
•Upon closing of the acquisition, we expect to redevelop the two existing
buildings, along with the services of The Davis Companies, into a Class A life
science project aggregating 400,000 RSF of technical office/laboratory space. We
will retain our wholly owned interest in the project upon completion of the
redevelopments.
•These two buildings are 100% under lease negotiation with several cutting-edge
life science companies.
•The redevelopment project is targeting initial occupancy in 2023.
•Parking garage with approximately 650 spaces.
•We expect to pursue additional entitlement opportunities for future development
of additional office/laboratory space at this site.
•We expect to complete this acquisition in December 2021.
•During the three months ended June 30, 2021, we completed acquisitions in our
key life science cluster submarkets aggregating 5.5 million SF (includes
Sequence Drive described in the next bullet); 4.7 million RSF of value-creation
opportunities; and 0.9 million RSF of operating space, for an aggregate purchase
price of $1.1 billion.
•In June 2021, we acquired five operating buildings at 6260, 6290, 6310, 6340,
and 6350 Sequence Drive aggregating 487,023 RSF, located in our Sorrento Mesa
submarket, for a purchase price of $298.5 million, with opportunity to increase
the campus by approximately 400,000 SF through ground-up development.
•The five operating buildings are currently 100% occupied with a
weighted-average remaining lease term of 2.7 years. We expect to develop or
redevelop these spaces upon expiration of the existing in-place leases.
•The aggregate 887,000 RSF from this acquisition provides a significant future
development opportunity to expand our existing Sequence District by Alexandria
campus into a flagship mega campus aggregating 1.9 million SF.

Key strategic transactions that generated capital for investment into our highly leased value-creation pipeline and acquisitions with development and redevelopment opportunities



•In April 2021, we sold a 70% partial interest in our 213 East Grand Avenue
property located in our South San Francisco submarket for a sales price of
$301.0 million, or $1,429 per RSF, representing capitalization rates of 4.5% and
4.0% (cash basis).
•In July 2021, we sold a 70% partial interest in our 400 Dexter Avenue North
property located in our Lake Union submarket for a sales price of $254.8
million, or $1,255 per RSF, representing capitalization rates of 4.1% and 4.2%
(cash basis).

Balance sheet management

Key metrics as of June 30, 2021



•$36.3 billion of total market capitalization.
•$27.4 billion of total equity capitalization.
•No debt maturing prior to 2024.
•12.5 years weighted-average remaining term of debt as of June 30, 2021.
•Investment-grade credit ratings ranked in the top 10% among all publicly traded
U.S. REITs as of June 30, 2021.
                                                                     June 30, 2021                             Goal for Fourth Quarter of 2021,
                                                   Quarter Annualized              Trailing 12 Months                     Annualized
Net debt and preferred stock to Adjusted                 5.8x                             6.2x                    Less than or equal to 5.2x
EBITDA
Fixed-charge coverage ratio                              4.9x                             4.6x                  Greater than or equal to 5.0x


                                       49

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Value-creation pipeline of new Class A development and redevelopment projects as a percentage of gross investments in real estate

June 30, 2021

Current and key near-term projects and key pending acquisition 84%

                       10%

leased/negotiating


Income-producing/potential cash flows/covered land play(1)                                        6%
Land                                                                                              2%


(1)Includes projects that have existing buildings that are generating or can
generate operating cash flows. Also includes development rights associated with
existing operating campuses.

Key capital events

•In June 2021, we entered into forward equity sales agreements aggregating $1.5
billion to sell 8.1 million shares of our common stock (including the exercise
of underwriters' option) at a public offering price of $184.00 per share, before
underwriting discounts and commissions.
•During the three months ended June 30, 2021, we settled a portion of these
forward equity sales agreements by issuing 4.9 million shares and received net
proceeds of $870.3 million.
•We expect to issue 3.1 million shares in the second half of 2021 to settle our
remaining outstanding forward equity sales agreements and receive net proceeds
of approximately $547.8 million.
•We also expect to issue 1.5 million shares in the second half of 2021 to settle
our remaining outstanding January 2021 forward equity sales agreements and
receive net proceeds of approximately $230.5 million.
•During the three months ended June 30, 2021, there was no sale activity under
our ATM common stock offering program. As of June 30, 2021 and as of the date of
this report, the remaining aggregate amount available under our current program
for future sales of common stock is $500.0 million.

Investments



•As of June 30, 2021, our investments aggregated $2.0 billion, including an
adjusted cost basis of $1.0 billion, unrealized gains of $1.0 billion, and $48.0
million of investments accounted for under the equity method of accounting.
•Investment income of $304.3 million for the three months ended June 30, 2021,
consisted of $60.2 million of realized gains and $244.0 million of unrealized
gains.

Industry and ESG leadership: catalyzing and leading the way for positive change to benefit human health and society



Industry leadership
•We were ranked in the top 10 of the world's largest and most impactful real
estate firms on the Forbes 2021 Global 2000 list determined based on sales,
profits, assets, and market value.
•In June 2021, we released our 2020 Environmental, Social & Governance Report,
which showcases our longstanding ESG commitment and leadership. Key highlights
in the report include the company's critical efforts to tackle climate change by
pioneering low-carbon and climate-resilient design solutions, mitigating
climate-related risk in our asset base, and investing in and providing essential
infrastructure for sustainable agrifoodtech companies; continuing strong
progress toward our 2025 environmental impact goals, including further reducing
carbon emissions; and catalyzing the health, wellness, safety, and productivity
of our employees and tenants, local communities, and the world at large through
the built environment and our social responsibility initiatives.

                                       50
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Operating summary

                                 Same Property Net Operating
                                        Income Growth                                                                            Favorable Lease Structure(1)
                                                                                                        Strategic Lease Structure by Owner and Operator

of Collaborative Life Science,


                                                                                                                               Agtech, and Technology Campuses
                                                                                                     Increasing cash flows
                                                                                                     Percentage of leases containing annual rent escalations                          95%
                                                    [[Image Removed: are-20210630_g2.jpg]]           Stable cash flows
     [[Image Removed: are-20210630_g1.jpg]]                                                          Percentage of triple                                                             94%
                                                                                                     net leases
                                                                                                     Lower capex burden
                                                                                                     Percentage of leases providing for the recapture of capital                      94%
                                                                                                     expenditures


                                     Rental Rate Growth:
                                   Renewed/Re-Leased Space                                                                                Margins(2)

                                                                                                                  Operating                                       Adjusted EBITDA
     [[Image Removed: are-20210630_g3.jpg]]         [[Image Removed: are-20210630_g4.jpg]]                           72%                                                69%




(1)Percentages calculated based on RSF as of June 30, 2021. (2)Represents percentages for the three months ended June 30, 2021.


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                                           Long-Duration Cash Flows From High-Quality, Diverse, and
                                                              Innovative Tenants

                     Investment-Grade or                                                             Long-Duration Lease Terms
              Publicly Traded Large Cap Tenants

                             53%                                                                             7.5 Years
                          of ARE's                                                                        Weighted-Average
                  Annual Rental Revenue(1)                                                               Remaining Term(2)

                                                                  Tenant Mix


                                                    [[Image Removed: are-20210630_g5.jpg]]


                                                 Percentage of ARE's Annual Rental Revenue(1)


(1)Represents annual rental revenue in effect as of June 30, 2021. Refer to the
"Non-GAAP measures and definitions" section within this Item 2 for additional
information.
(2)Based on aggregate annual rental revenue in effect as of June 30, 2021. Refer
to definition of "Annual rental revenue" in the "Non-GAAP measures and
definitions" section within this Item 2 for additional information on our
methodology on annual rental revenue for unconsolidated real estate joint
ventures.
(3)Represents annual rental revenue currently generated from office space that
is targeted for a future change in use. The weighted-average remaining term of
these leases is 2.9 years.
(4)Represents annual rental revenue from publicly traded technology tenants with
an average daily market capitalization greater than $200 billion for the twelve
months ended June 30, 2021.
(5)Our other tenants, aggregating 5.0% of our annual rental revenue, comprise
3.9% of annual rental revenue from technology, professional services, finance,
telecommunications, and construction/real estate companies and only 1.1% from
retail-related tenants.
                                       52
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                                             High-Quality Cash Flows From High-Quality Tenants and
                                                      Class A Properties in AAA Locations

                          Industry-Leading                                                          AAA Locations
                            Tenant Roster

                                 85%
                      of ARE's Top 20 Tenants'
                      Annual Rental Revenue(1)                                         [[Image Removed: are-20210630_g6.jpg]]
                     Is From Investment-Grade or
                           Publicly Traded
                          Large Cap Tenants
                                                                                    Percentage of ARE's Annual Rental Revenue(1)

       Solid Historical                                                        Occupancy Across Key Locations(3)
         Occupancy(2)

             96%                                                           

[[Image Removed: are-20210630_g7.jpg]]

Over 10 Years





(1)Represents annual rental revenue in effect as of June 30, 2021. Refer to the
"Non-GAAP measures and definitions" section within this Item 2 for additional
information.
(2)Represents average occupancy of operating properties in North America as of
each December 31 for the last 10 years and as of June 30, 2021.
(3)As of June 30, 2021.
(4)Refer to the "Summary of occupancy percentages in North America" section
within this Item 2 for additional information.
                                       53
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Leasing

The following table summarizes our leasing activity at our properties:


                                                              Three Months Ended                                                     Six Months Ended                                                 Year Ended
                                                                June 30, 2021                                                          June 30, 2021                                              December 31, 2020
                                                     Including                                                              Including                                                   Including
                                                Straight-Line Rent                    Cash Basis                       Straight-Line Rent                   Cash Basis              Straight-Line Rent                 Cash Basis
(Dollars per RSF)
Leasing activity:
Renewed/re-leased space(1)
Rental rate changes                                     42.4%                                  25.4%                           40.7%                                 23.3%                          37.6%                       18.3%
New rates                                         $58.70                                $56.16                           $58.41                               $55.82                       $49.51                        $46.53
Expiring rates                                    $41.22                                $44.77                           $41.51                               $45.29                       $35.99                        $39.32
RSF                                            1,472,713                                                              1,994,538                                                         2,556,833
Tenant improvements/leasing
commissions                                       $32.06                                                                 $31.82                                                            $35.08
Weighted-average lease term                         5.8 years                                                              6.1 years                                                            6.0 years

Developed/redeveloped previously
vacant space leased(2)
New rates                                         $57.61                                $53.52                           $51.56                               $47.91                       $56.67                        $53.61
RSF                                              461,125                                                              1,616,959                                                         1,802,013
Weighted-average lease term                         7.5 years                                                              9.8 years                                                            9.0 years

Leasing activity summary (totals):
New rates                                         $58.44                                $55.53                           $55.34                               $52.28                       $52.47                        $49.46
RSF                                            1,933,838      (3)                                                     3,611,497      (4)                                                4,358,846
Weighted-average lease term                         6.2 years                                                              7.7 years                                                            7.3 years

Lease expirations(1)
Expiring rates                                    $40.06                                $43.13                           $40.25                               $43.35                       $36.03                        $39.01
RSF                                            1,712,307                                                              2,459,582                                                         3,560,188


Leasing activity includes 100% of results for each property in which we have an investment in North America.



(1)Excludes month-to-month leases aggregating 88,305 RSF and 96,383 RSF as of
June 30, 2021, and December 31, 2020, respectively.
(2)Refer to "New Class A development and redevelopment properties: summary of
pipeline" section within this Item 2 for additional information on total project
costs.
(3)Represents the highest leasing activity in a single quarter in Company
history.
(4)During the six months ended June 30, 2021, we granted tenant concessions/free
rent averaging 2.6 months with respect to the 3,611,497 RSF leased.
Approximately 47% of the leases executed during the six months ended
June 30, 2021, did not include concessions for free rent.

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Summary of contractual lease expirations

The following table summarizes information with respect to the contractual lease expirations at our properties as of June 30, 2021:


                                                                            Percentage of                    Annual Rental Revenue                Percentage of Total
         Year                             RSF                                Occupied RSF                         (per RSF)(1)                   Annual Rental Revenue

         2021    (2)                     913,052                                        2.7  %                     $ 46.74                                     2.6  %
         2022                          2,503,192                                        7.3  %                     $ 45.14                                     6.8  %
         2023                          3,472,768                                       10.1  %                     $ 40.58                                     8.5  %
         2024                          2,912,682                                        8.5  %                     $ 43.28                                     7.6  %
         2025                          2,778,313                                        8.1  %                     $ 51.54                                     8.7  %
         2026                          2,077,113                                        6.0  %                     $ 48.24                                     6.1  %
         2027                          2,109,753                                        6.1  %                     $ 50.48                                     6.4  %
         2028                          2,951,361                                        8.6  %                     $ 50.79                                     9.1  %
         2029                          2,132,286                                        6.2  %                     $ 53.42                                     6.9  %
         2030                          2,299,958                                        6.7  %                     $ 53.53                                     7.5  %
      Thereafter                      10,225,279                                       29.7  %                     $ 48.19                                    29.8  %

(1)Represents amounts in effect as of June 30, 2021. (2)Excludes month-to-month leases aggregating 88,305 RSF as of June 30, 2021.



The following tables present information by market with respect to our lease
expirations in North America as of June 30, 2021, for the remainder of 2021, and
all of 2022:
                                                                                          2021 Contractual Lease Expirations (in RSF)

                                                                                                        Targeted for                                                                     Annual Rental
                                                                         Negotiating/                   Development/                    Remaining                                           Revenue
                Market                            Leased                 Anticipating                 Redevelopment(1)               Expiring Leases                Total2)              (per RSF)(3)
Greater Boston                                       57,247                      62,312                          202,428                      35,120                    357,107          $    46.37
San Francisco Bay Area                              122,534                       4,570                                -                      73,301                    200,405               57.99
New York City                                        30,408                           -                                -                       4,973                     35,381                    N/A
San Diego                                            46,586                           -                           84,359                      35,085                    166,030               37.40
Seattle                                              24,990                       6,053                                -                      33,341                     64,384               18.62
Maryland                                              7,268                           -                                -                          76                      7,344               35.23
Research Triangle                                    23,435                           -                                -                      43,911                     67,346               30.78
Canada                                                    -                           -                                -                           -                          -                   -
Non-cluster/other markets                                 -                           -                                -                      15,055                     15,055               86.16
Total                                               312,468                      72,935                          286,787                     240,862                    913,052          $    46.74
Percentage of expiring leases                            34  %                        8  %                            31  %                       27  %                     100  %

                                                                                          2022 Contractual Lease Expirations (in RSF)

                                                                                                        Targeted for                                                                     Annual Rental
                                                                         Negotiating/                   Development/                    Remaining                                           Revenue
                Market                            Leased                 Anticipating                 Redevelopment(1)             Expiring Leases(4)                Total               (per RSF)(3)
Greater Boston                                      118,555                     149,849                                -                     275,190    (5)             543,594          $    58.71
San Francisco Bay Area                                    -                      33,498                          490,127                     233,583                    757,208               52.08
New York City                                             -                      14,891                                -                       3,264                     18,155                    N/A
San Diego                                           103,730                           -                          250,028                     211,117                    564,875               36.31
Seattle                                                   -                           -                           51,255                     151,092                    202,347               34.39
Maryland                                              7,638                      18,090                                -                      50,865                     76,593               29.11
Research Triangle                                         -                      30,039                                -                     207,409                    237,448               22.48
Canada                                                    -                           -                                -                      28,623                     28,623               22.57
Non-cluster/other markets                                 -                           -                                -                      74,349                     74,349               44.25
Total                                               229,923                     246,367                          791,410                   1,235,492                  2,503,192          $    45.14
Percentage of expiring leases                             9  %                       10  %                            32  %                       49  %                     100  %



(1)Represents RSF targeted for development or redevelopment upon expiration of
existing in-place leases, primarily related to recently acquired properties.
Refer to "Investments in real estate - value-creation square footage currently
in rental properties" in the "Non-GAAP measures and definitions" section within
this Item 2 for additional details on value-creation square feet currently
included in rental properties.
(2)Excludes month-to-month leases aggregating 88,305 RSF as of June 30, 2021.
(3)Represents amounts in effect as of June 30, 2021.
(4)The largest remaining contractual lease expiration includes one lease for
62,490 RSF in our Research Triangle submarket.
(5)57% of the remaining expiring leases in Greater Boston are located in our
Cambridge/Inner Suburbs submarket.

                                       55
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Top 20 tenants


           85% of Top 20 Annual Rental Revenue From Investment-Grade
                    or Publicly Traded Large Cap Tenants(1)

Our properties are leased to a high-quality and diverse group of tenants, with
no individual tenant accounting for more than 3.3% of our annual rental revenue
in effect as of June 30, 2021. The following table sets forth information
regarding leases with our 20 largest tenants in North America based upon annual
rental revenue in effect as of June 30, 2021 (dollars in thousands, except
average market cap):
                                                                                                                                                        Annual                 Percentage of Aggregate                                                        Average Market
                                                                      Remaining Lease Term(1)                       Aggregate                           Rental                  Annual Rental Revenue              Investment-Grade Credit Ratings                Cap(1)
                                Tenant                                       (in Years)                                RSF                            Revenue(1)                         (1)                     Moody's                        S&P           (in billions)
  1          Bristol-Myers Squibb Company                                        7.2                                 916,234                  $          53,100                            3.3  %                   A2                          A+            $     140.0
  2          Takeda Pharmaceutical Company Ltd.                                  8.1                                 606,249                             39,342                            2.4                     Baa2                        BBB+           $      55.8
  3          Moderna, Inc.                                                      11.2                                 855,458                             39,341                            2.4                      -                            -            $      48.9
  4          Facebook, Inc.                                                     10.5                                 903,786                             38,595                            2.4                      -                            -            $     797.7
  5          Eli Lilly and Company                                               7.5                                 580,693                             37,047                            2.3                      A2                          A+            $     167.4
  6          Illumina, Inc.                                                      9.1                                 891,495                             36,118                            2.2                     Baa3                         BBB           $      55.3
  7          Sanofi                                                              8.1                                 494,693                             35,040                            2.1                      A1                          AA            $     126.5
  8          Novartis AG                                                         7.1                                 423,914                             30,216                            1.9                      A1                          AA-           $     217.7
  9          Uber Technologies, Inc.                                            61.4      (2)                      1,009,188                             27,379                            1.7                      -                            -            $      84.7
 10          Roche                                                               2.8      (3)                        546,893                             26,040                            1.6                     Aa3                          AA            $     299.6
 11          bluebird bio, Inc.                                                  5.9                                 312,805                             23,142                            1.4                      -                            -            $       3.0
 12          Maxar Technologies                                                  4.2      (4)                        478,000                             21,803                            1.3                      -                            -            $       2.1
 13          Massachusetts Institute of Technology                               7.5                                 257,626                             21,145                            1.3                     Aaa                          AAA           $         -
 14          United States Government                                           13.8                                 918,516                             20,236                            1.2                     Aaa                          AA+           $         -
 15          The Children's Hospital Corporation                                17.3                                 269,816                             20,066                            1.2                     Aa2                          AA            $         -
 16          Jazz Pharmaceuticals, Inc.                                          9.2                                 198,041                             20,003                            1.2                      -                            -            $       8.6
 17          New York University                                                10.2                                 204,691                             19,531                            1.2                     Aa2                          AA-           $         -
 18          Merck & Co., Inc.                                                  12.9                                 311,015                             19,392                            1.2                      A1                          AA-           $     200.2
 19          Pfizer Inc.                                                         3.7                                 416,979                             17,762                            1.1                      A2                          A+            $     207.3
 20          FibroGen, Inc.                                                      7.4                                 234,249                             16,896                            1.0                      -                            -            $       3.4
             Total/weighted-average                                             11.1      (2)                     10,830,341                  $         562,194                           34.4  %


Annual rental revenue and RSF include 100% of each property managed by us in North America.



(1)Based on aggregate annual rental revenue in effect as of June 30, 2021. Refer
to the definitions of "Annual rental revenue" and "Investment-grade or publicly
traded large cap tenants" in the "Non-GAAP measures and definitions" section
within this Item 2 for our methodologies on annual rental revenue from
unconsolidated real estate joint ventures and average market capitalization.
(2)Includes (i) ground leases for land at 1455 and 1515 Third Street (two
buildings aggregating 422,980 RSF) and (ii) leases at 1655 and 1725 Third Street
(two buildings aggregating 586,208 RSF) owned by our unconsolidated real estate
joint venture in which we have an ownership interest of 10%. Annual rental
revenue is presented using 100% of the annual rental revenue of our consolidated
properties and our share of annual rental revenue for our unconsolidated real
estate joint ventures. Refer to footnote 1 for additional details. Excluding the
ground lease, the weighted-average remaining lease term for our top 20 tenants
was 8.5 years as of June 30, 2021.
(3)Includes 197,787 RSF expiring in 2022 at our recently acquired property at
651 Gateway Boulevard in our South San Francisco submarket. Upon expiration of
the lease, 651 Gateway Boulevard will be redeveloped into a Class A
office/laboratory building. Excluding this 197,787 RSF, the weighted-average
remaining term of space leased to Roche is 3.4 years.
(4)Represents remaining lease term at two properties with future redevelopment
and development opportunities. The leases with this tenant were in place when we
acquired the property during the three months ended December 31, 2019.
                                       56
--------------------------------------------------------------------------------

Locations of properties



The locations of our properties are diversified among a number of life science,
agtech, and technology cluster markets. The following table sets forth the total
RSF, number of properties, and annual rental revenue in effect as of June 30,
2021, in each of our markets in North America (dollars in thousands, except per
RSF amounts):
                                                                                                     RSF                                                                                                                    Annual Rental Revenue
Market                                         Operating                Development               Redevelopment                 Total                 % of Total            Number of Properties               Total                 % of Total            Per RSF
Greater Boston                                    9,893,984               510,116                    490,545                 10,894,645                        27  %                   77                $      579,594                       36  %       $ 61.32
San Francisco Bay Area                            8,046,553               368,149                     92,147                  8,506,849                        21                      66                       408,038                       25            61.46
New York City                                     1,160,472                     -                    120,027                  1,280,499                         3                       5                        83,961                        5            72.80
San Diego                                         7,102,797               341,891                    117,212                  7,561,900                        19                      88                       263,165                       16            39.49
Seattle                                           2,628,577                     -                    213,976                  2,842,553                         7                      40                       108,354                        7            42.26
Maryland                                          3,593,787                84,264                    344,226                  4,022,277                        10                      50                        95,592                        6            26.88
Research Triangle                                 3,137,115               410,000                    325,936                  3,873,051                        10                      35                        71,093                        4            24.42
Canada                                              268,551                     -                          -                    268,551                         1                       3                         5,164                        -            24.98
Non-cluster/other markets                           600,709                     -                          -                    600,709                         1                      13                        11,174                        1            40.41
Properties held for sale                            225,849                     -                          -                    225,849                         1                       4                         6,168                        -                 N/A
North America                                    36,658,394             1,714,420                  1,704,069                 40,076,883                       100  %                  381                $    1,632,303                      100  %       $ 48.65
                                                                                       3,418,489


Summary of occupancy percentages in North America



The following table sets forth the occupancy percentages for our operating
properties and our operating and redevelopment properties in each of our North
America markets, excluding properties held for sale, as of the following dates:

                                                               Operating Properties                                            Operating and Redevelopment Properties
Market                                       6/30/21                   3/31/21                6/30/20                  6/30/21                  3/31/21                6/30/20
Greater Boston                                    95.5  % (1)               96.2  %                98.2  %                    91.0  %                91.5  %                95.6  %
San Francisco Bay Area                            94.0    (1)(2)            95.4                   94.7                       92.9                   94.3                   90.6
New York City                                     99.4                      99.4                   97.1                       90.1                   89.8                   86.2
San Diego                                         93.8    (1)               93.3                   91.8                       92.3                   90.3                   90.8
Seattle                                           97.6                      96.8                   95.1                       90.2                   89.6                   95.1
Maryland                                          98.9                      97.9                   93.9                       90.3                   90.4                   93.2
Research Triangle                                 92.8    (1)               90.8                   96.8                       84.1                   73.7                   96.8
Subtotal                                          95.2                      95.3                   95.1                       90.9                   89.9                   92.6
Canada                                            77.0                      81.6                   90.0                       77.0                   81.6                   90.0
Non-cluster/other markets                         46.0                      52.6                   70.8                       46.0                   52.6                   70.8
North America                                     94.3  % (1)               94.5  %                94.8  %                    90.1  %                89.2  %                92.3  %



(1)Excludes 1.4 million RSF, or 3.8%, of vacancy at recently acquired properties
in our North America markets, representing lease-up opportunities that are
expected to provide incremental annual rental revenues in excess of $55 million.
Approximately 35% of the vacant 1.4 million RSF is currently under
leased/negotiating, with occupancy expected primarily over the next two
quarters. Excluding these acquired vacancies, occupancy of operating properties
in North America was 98.1% as of June 30, 2021. The following table provides
vacancy detail for our recent acquisitions:

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