INDIANAPOLIS - Eli Lilly and Company (NYSE: LLY) announced today it will share new Taltz (ixekizumab) data from multiple long-term and post-hoc analyses that indicate sustained efficacy in patients with psoriasis and psoriatic arthritis.

Notably, Lilly will share results from the extension period of UNCOVER-3 demonstrating five-year sustained efficacy of Taltz in patients with psoriasis in treating challenging body areas, such as the scalp, nails, palms and soles. These studies will be presented at the 29th annual European Academy of Dermatology and Venereology (EADV) Congress, taking place virtually October 29-31, 2020.

'Finding an effective long-term treatment option that can clear hard-to-treat body areas that patients find particularly burdensome, such as the scalp and nails, is one of the most important considerations when treating psoriasis,' said Andrew Blauvelt, M.D., M.B.A., a board-certified dermatologist, President of Oregon Medical Research Center, and lead author of the UNCOVER-3 five-year disclosure. 'These data demonstrate that Taltz was able to provide sustained responses in these challenging skin areas and should help physicians make informed treatment decisions for their psoriasis patients.'

About Taltz

Taltz is a monoclonal antibody that selectively binds with interleukin 17A (IL-17A) cytokine and inhibits its interaction with the IL-17 receptor. IL-17A is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Taltz inhibits the release of pro-inflammatory cytokines and chemokines.

About Moderate to Severe Plaque Psoriasis

Psoriasis is a chronic, immune disease that affects the skin. It occurs when the immune system sends out faulty signals that speed up the growth cycle of skin cells. Psoriasis affects approximately 125 million people worldwide, approximately 20 percent of whom have moderate to severe plaque psoriasis. The most common form of psoriasis, plaque psoriasis, appears as raised, red patches covered with a silvery white buildup of dead skin cells. Patients with plaque psoriasis often have other serious health conditions, such as diabetes and heart disease and experience negative impact on their quality of life.

About Psoriatic Arthritis

Psoriatic arthritis (PsA) is a chronic, progressive form of inflammatory arthritis that can cause swelling, stiffness and pain in and around the joints and impaired physical function. It occurs when an overactive immune system sends out faulty signals that cause inflammation, leading to swollen and painful joints and tendons. PsA can affect peripheral joints in the arms and legs (elbows, wrists, hands and feet). If left untreated, PsA can cause permanent joint damage. Up to 30 percent of people with psoriasis also develop PsA.

About Lilly in Dermatology

By following the science through uncharted territory, we continue Lilly's legacy of delivering innovative medicines that address unmet needs and have significant impacts on people's lives around the world. Skin-related diseases are more than skin deep. We understand the devastating impact this can have on people's lives. At Lilly, we are relentlessly pursuing a robust dermatology pipeline to provide innovative, patient-centered solutions so patients with skin-related diseases can aspire to live life without limitations.

About Eli Lilly and Company

Lilly is a global health care leader that unites caring with discovery to create medicines that make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism.

This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about Taltz (ixekizumab) as a treatment for patients with psoriasis or psoriatic arthritis and reflects Lilly's current belief. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of development and commercialization. Among other things, there can be no guarantee that future study results will be consistent with the results to date or that Taltz will receive additional regulatory approvals or be commercially successful.

Contact:

Kevin Hern

Tel: 317-277-1838

Email: hernkevinr@lilly.com

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