Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 7.31B 6.49B 6.07B 5.53B 10.42B 704B 10.56B 73.48B 28.44B 359B 27.45B 26.86B 1,152B P/E 2026 *
-12.3x
P/E 2027 * -22.6x
Enterprise Value 7.21B 6.4B 5.99B 5.46B 10.27B 694B 10.41B 72.44B 28.04B 353B 27.07B 26.48B 1,135B EV / Sales 2026 *
7.84x
EV / Sales 2027 * 5.41x
Free-Float
99.05%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 2012-06-30
Chief Executive Officer 64 2019-12-31
Director of Finance/CFO 64 2000-04-30
Director TitleAgeSince
Director/Board Member 64 2005-12-12
Director/Board Member 73 2002-04-30
Director/Board Member 64 2019-03-24
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 7.31B
+4.16%+3.04%+49.37%+94.17% 74.41B
-1.38%-1.82%+24.07%+77.69% 59.26B
+1.32%-0.07%+4.87%+35.27% 47.14B
-3.02%-5.20%+27.94%+32.51% 42.91B
+0.31%+3.02%+348.95%+643.82% 44.13B
-1.96%-0.33%+7.04%+99.46% 40.79B
+3.32%+3.49%+10.10%+51.23% 30.77B
-2.68%+2.92%+29.63%+22.72% 29.31B
-4.86%-10.66%-26.27%+330.06% 23.71B
Average -0.36%-0.52%+52.86%+154.10% 43.6B
Weighted average by Cap. +0.02%-0.32%+58.02%+145.77%

Financials

2026 *2027 *
Net sales 920M 817M 764M 696M 1.31B 88.53B 1.33B 9.24B 3.58B 45.09B 3.45B 3.38B 145B 1.36B 1.21B 1.13B 1.03B 1.94B 131B 1.97B 13.71B 5.31B 66.92B 5.12B 5.01B 215B
Net income -576M -512M -479M -436M -821M -55.48B -832M -5.79B -2.24B -28.26B -2.16B -2.12B -90.76B -330M -293M -274M -250M -471M -31.79B -477M -3.32B -1.28B -16.19B -1.24B -1.21B -52B
Net Debt -103M -91.48M -85.55M -77.95M -147M -9.92B -149M -1.03B -401M -5.05B -387M -378M -16.22B 68.31M 60.67M 56.74M 51.7M 97.34M 6.58B 98.68M 686M 266M 3.35B 256M 251M 10.76B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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Global
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