Lipigon Pharmaceuticals AB (Lipigon) announced that its blood lipid-lowering drug candidate, Lipisense®?, has demonstrated with statistical certainty a significant reduction in the concentration of the target protein ANGPTL4 in the blood of healthy individuals. In the recent Phase I study involving Lipisense®? where 24 healthy participants received four repeated doses of either Lipisense®?

or a placebo, a reduction in the target protein ANG PTL4 was observed in those administered Lipisense®? The decrease in blood plasma reached -29% for individuals undergoing active treatment compared to the placebo group at the 90-day follow-up after the final dose (95% confidence interval: -55% to -3%, P-value: 0.03). The statistical analysis was performed post hoc on the study data by the sponsor.

The results are encouraging, suggesting a potential positive impact on cardiometabolic diseases like type 2 diabetes and cardiovascular diseases.