PolyPid Ltd. announced a new publication highlighting the potent antibacterial activity of D-PLEX(100) and its potential as an effective prophylactic drug against the most prevalent bacteria causing surgical site infections (SSIs), including resistant strains. The paper, entitled, "Potent antibacterial activity in surgical wounds with local administration of D-PLEX(100) was recently published in the European Journal of Pharmaceutical Sciences and can be found here. The efficacy and safety of D-PLEX(50) for the prevention of abdominal colorectal SSIs are currently being further evaluated in the SHIELD II Phase 3 clinical trial.

Top-line results are expected in mid-2024. Following the administration of D-PLEX (Polymer-Lipid Encapsulation matriX) technology pairs with Active Pharmaceutical Ingredients, enabling a prolonged and continuous release of the broad-spectrum antibiotic doxycycline, resulting in a high local concentration of the drug for a period of 30 days for the prevention of SSIs, with additional potential to prevent SSIs caused by antibiotic-resistant bacteria at the surgical site. D-PLEX(100") received Breakthrough Therapy Designation from the U.S. FDA for the prevention of SSIs in patients undergoing elective colorectal surgery.

D-PLEX(100") also received three Qualified Infectious Disease Product (QIDP) designations, and three Fast Trackdesignations for the prevention of SSIsin patients undergoing elective coloreCTal surgery, post-abdominal surgery incisional infection and for the prevention of sternal wound infection post-cardiac surgery. Through locally administered, controlled,release therapeutics, PolyPid's proprietary PLEX (Polymer-LIPid Encapsulation matri X) technology pairs with Active Pharmaceutical ingredients (APIs), enabling precise delivery of drugs at optimal release rates over durations ranging from several days to months. PolyPid's lead product candidate D-PLEX(100).

is in Phase 3 clinical trial for the prevention of abdominal colores colorectal SSIs are currently being further evaluated in the SHIELD II Phase 3 clinical trial. Top-line results are expected in mid-2024. About D-PLEX(100) D-PLEX(100,) PolyPid's lead product candidate, is designed to provide local prolonged and controlled anti-bacterial activity directly at the surgical site to prevent SSIs.

Following the administration of D-PLEX(100) into the surgical site, the PLEX (Polymer-Lipid Encapsulation matriX) technology pairs with Active Pharmaceutical Ingredients, enabling a prolonged and continuous release of the broad-spectrum antibiotic doxycycline, resulting in a high local concentration of the drug for a period of 30 days for the prevention of SSIs, with additional potential to prevent SSIs caused by antibiotic-resistant bacteria at the surgical site. D-PLEX(100) received Breakthrough Therapy Designation from the U.S. FDA for the prevention of SSIs in patients undergoing elective colorectal surgery. D-PLEX(100) also received three Qualified Infectious Disease Product (QIDP) designations, and three Fast Track designations for the prevention of SSIs in patients undergoing elective colorectal surgery, post-abdominal surgery incisional infection and for the prevention of sternal wound infection post-cardiac surgery.