Certain Common Stock of Renascience Inc. are subject to a Lock-Up Agreement Ending on 22-MAR-2022. These Common Stock will be under lockup for 179 days starting from 24-SEP-2021 to 22-MAR-2022. Details: During the period from the date to March 22, 2022, which is the 180th day from the date, Toshio Miyata, the lender and seller, Keiko Kato and Mitsuyo Miyata, the sellers, Aya Miyata, Moemi Miyata, Kazuyoshi Miyata, Otsuka Holdings Co., Ltd. and Kazuo Noguchi, normally holds the shares on the date of the conclusion of the principal underwriting contract without obtaining the prior written consent of the lead managing underwriter promise not to issue, transfer or sell shares or securities that have the right to acquire the Company's common stock. The shareholders, Daiwa Japan-Taiwan Bio-Venture Investment Business Limited Liability Union, THVP-1 Investment Business Limited Liability Union, KSP No. 5 Investment Business Limited Liability Union and 77 New Business Investment Business Limited Liability Union, are the lead managing underwriters. During the period from the date of conclusion of the original underwriting contract for the sale of the offering and the underwriter's purchase transaction to December 22, 2021, which is the 90th day from the listing (start of trading) date, the lead managing underwriter Issuance, transfer or sale of the Company's common stock and securities that have the right to acquire the Company's common stock, etc. held by own calculation on the date of conclusion of the principal underwriting contract without obtaining prior written consent (however, the selling price) is more than 1.5 times the issue price in the offering or the sale price in the sale, and does not sell at the Tokyo Stock Exchange through the lead managing underwriter.