Shire : Form 8.5 (EPT/RI) - Replacement of Shire

AMENDMENT Section (2a & 2b)

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:	Morgan Stanley & Co. International plc
(b) Name of offeror/offeree in relation to whose relevant securities this form relates: Use a separate form for each offeror/offeree	Shire plc
(c) Name of the party to the offer with which exempt principal trader is connected:	Shire plc
(d) Date dealing undertaken:	19 DECEMBER 2018
(e) In addition to the company in 1(b) above, is the exempt principal trader making disclosures in respect of any other party to this offer? If it is a cash offer or possible cash offer, state 'N/A'	Yes - Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security	Purchases/ sales	Total number of securities	Highest price per unit paid/received	Lowest price per unit paid/received
5p ordinary	PURCHASES	375	48.9000 EUR	48.9000 EUR
5p ordinary	SALES	375	48.9000 EUR	48.9000 EUR
5p ordinary	PURCHASES	5,234,394	44.6900 GBP	43.7100 GBP
5p ordinary	SALES	2,627,883	44.6850 GBP	43.8206 GBP
5p ordinary	PURCHASES	671,290	56.3442 USD	55.8338 USD
5p ordinary	SALES	106,869	56.1193 USD	56.0463 USD

(b) Cash-settled derivative transactions

Class of relevant security	Product description e.g. CFD	Nature of dealing e.g. opening/closing a long/short position, increasing/reducing a long/short position	Number of reference securities	Price per unit
ADR	CFD	LONG	15,500	168.0691 USD
ADR	CFD	LONG	300	168.1700 USD
ADR	CFD	LONG	100	168.5200 USD
ADR	CFD	LONG	100	168.8750 USD
5p ordinary	CFD	LONG	953	43.8206 GBP
5p ordinary	CFD	LONG	7,764	43.8206 GBP
5p ordinary	CFD	LONG	346	43.8206 GBP
5p ordinary	CFD	LONG	105,062	43.8206 GBP
5p ordinary	CFD	LONG	30,145	43.8206 GBP
5p ordinary	CFD	LONG	1,599	43.8206 GBP
5p ordinary	CFD	LONG	1,410	44.3200 GBP
5p ordinary	CFD	LONG	37,999	44.3610 GBP
5p ordinary	CFD	LONG	2,449	44.3610 GBP
5p ordinary	CFD	LONG	42,455	44.3610 GBP
5p ordinary	CFD	LONG	8,430	44.3610 GBP
5p ordinary	CFD	LONG	10,238	44.3610 GBP
5p ordinary	CFD	LONG	36,314	44.3610 GBP
5p ordinary	CFD	LONG	8,230	44.3610 GBP
5p ordinary	CFD	LONG	200,000	44.4279 GBP
5p ordinary	CFD	LONG	170	44.4634 GBP
5p ordinary	CFD	LONG	20,000	44.4682 GBP
5p ordinary	CFD	LONG	75,000	44.4682 GBP
5p ordinary	CFD	SHORT	282	44.0132 GBP
5p ordinary	CFD	SHORT	80,000	44.2827 GBP
5p ordinary	CFD	SHORT	136	44.3056 GBP
5p ordinary	CFD	SHORT	3,471	44.3177 GBP
5p ordinary	CFD	SHORT	6,126	44.3177 GBP
5p ordinary	CFD	SHORT	12,583	44.3200 GBP
5p ordinary	CFD	SHORT	12,583	44.3200 GBP
5p ordinary	CFD	SHORT	50,953	44.3200 GBP
5p ordinary	CFD	SHORT	108,000	44.3577 GBP
5p ordinary	CFD	SHORT	71,000	44.3577 GBP
5p ordinary	CFD	SHORT	157,425	44.3710 GBP
5p ordinary	CFD	SHORT	208,578	44.3728 GBP
5p ordinary	CFD	SHORT	154,118	44.3821 GBP
5p ordinary	CFD	SHORT	457,820	44.3933 GBP
5p ordinary	CFD	SHORT	4,940	44.4675 GBP
5p ordinary	CFD	LONG	1,996	44.3150 GBP
5p ordinary	CFD	LONG	90,000	56.2478 USD
5p ordinary	CFD	SHORT	33,200	55.8338 USD
5p ordinary	CFD	SHORT	15,500	55.8338 USD
5p ordinary	CFD	SHORT	6,800	55.8338 USD
5p ordinary	CFD	SHORT	6,230	55.8338 USD
5p ordinary	CFD	SHORT	350	55.8617 USD
5p ordinary	CFD	SHORT	17,980	55.8617 USD
5p ordinary	CFD	SHORT	8,584	56.0404 USD
5p ordinary	CFD	SHORT	4,416	56.0404 USD
5p ordinary	CFD	SHORT	37,300	56.0808 USD
5p ordinary	CFD	SHORT	20,100	56.0808 USD
5p ordinary	CFD	SHORT	16,800	56.0808 USD
5p ordinary	CFD	SHORT	4,700	56.0808 USD
5p ordinary	CFD	SHORT	3,300	56.0808 USD
5p ordinary	CFD	SHORT	3,100	56.0808 USD
5p ordinary	CFD	SHORT	2,500	56.0808 USD
5p ordinary	CFD	SHORT	1,600	56.0808 USD
5p ordinary	CFD	SHORT	50,000	56.1632 USD
5p ordinary	CFD	SHORT	55,000	56.1664 USD
5p ordinary	CFD	SHORT	5,800	56.2011 USD
5p ordinary	CFD	SHORT	2,700	56.2011 USD
5p ordinary	CFD	SHORT	2,132	56.2011 USD
5p ordinary	CFD	SHORT	12,500	56.2011 USD
5p ordinary	CFD	SHORT	75,000	56.2108 USD
5p ordinary	CFD	SHORT	210,000	56.2134 USD
5p ordinary	CFD	SHORT	17,980	56.2711 USD
5p ordinary	CFD	SHORT	350	56.2711 USD
5p ordinary	CFD	SHORT	5,900	56.3442 USD
5p ordinary	CFD	SHORT	12,400	56.3442 USD
5p ordinary	CFD	SHORT	2,553	56.3442 USD
5p ordinary	CFD	SHORT	2,700	56.3442 USD

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security	Product description e.g. call option	Writing, purchasing, selling, varying etc.	Number of securities to which option relates	Exercise price per unit	Typee.g. American, European etc.	Expiry date	Option money paid/ received per unit
N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

(ii) Exercise

Class of relevant security	Product description e.g. call option	Exercising/ exercised against	Number of securities	Exercise price per unit
N/A	N/A	N/A	N/A	N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security	Nature of dealing e.g. subscription, conversion	Details	Price per unit (if applicable)
N/A	N/A	N/A	N/A

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer: Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

NONE

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to: (i) the voting rights of any relevant securities under any option; or (ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced: If there are no such agreements, arrangements or understandings, state 'none'

NONE

Date of disclosure:	21 DECEMBER 2018
Contact name:	Craig Horsley
Telephone number:	[phone]

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on [phone].

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.