Shire : Form 8.5 (EPT/RI) - Replacement of Shire plc

AMENDMENT Section 2(b) & 2c(i)

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:	Morgan Stanley Capital Services LLC
(b) Name of offeror/offeree in relation to whose relevant securities this form relates: Use a separate form for each offeror/offeree	Shire plc
(c) Name of the party to the offer with which exempt principal trader is connected:	Shire plc
(d) Date dealing undertaken:	17 DECEMBER 2018
(e) In addition to the company in 1(b) above, is the exempt principal trader making disclosures in respect of any other party to this offer? If it is a cash offer or possible cash offer, state 'N/A'	Yes - Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security	Purchases/ sales	Total number of securities	Highest price per unit paid/received	Lowest price per unit paid/received
ADR	PURCHASES	8	171.1300 USD	169.0300 USD
ADR	SALES	2,249	172.1600 USD	168.9200 USD

(b) Cash-settled derivative transactions

Class of relevant security	Product description e.g. CFD	Nature of dealing e.g. opening/closing a long/short position, increasing/reducing a long/short position	Number of reference securities	Price per unit
ADR	CFD	LONG	1,700	169.8702 USD
ADR	CFD	LONG	2,070	170.1748 USD
ADR	CFD	LONG	70	170.2200 USD
ADR	CFD	LONG	300	171.8900 USD
ADR	CFD	LONG	100	171.9600 USD
ADR	CFD	LONG	100	171.9600 USD
ADR	CFD	SHORT	600,000	4.3000 USD
ADR	CFD	SHORT	1	171.1300 USD
ADR	CFD	SHORT	1	171.1300 USD
5p ordinary	CFD	LONG	88	45.3440 GBP
5p ordinary	CFD	LONG	7,110	45.4255 GBP
5p ordinary	CFD	SHORT	44	45.2706 GBP
5p ordinary	CFD	SHORT	11,152	45.4013 GBP
5p ordinary	CFD	SHORT	4,879	45.4013 GBP
5p ordinary	CFD	SHORT	2,227	45.4013 GBP
5p ordinary	CFD	SHORT	19,202	45.4013 GBP
5p ordinary	CFD	SHORT	12,278	45.4013 GBP
5p ordinary	CFD	SHORT	1,309	45.4013 GBP
5p ordinary	CFD	SHORT	2,638	45.4013 GBP
5p ordinary	CFD	SHORT	2,755	45.4013 GBP
5p ordinary	CFD	SHORT	17,484	45.4013 GBP
5p ordinary	CFD	SHORT	10,128	45.4013 GBP
5p ordinary	CFD	SHORT	3,105	45.4013 GBP
5p ordinary	CFD	SHORT	46,955	45.4013 GBP
5p ordinary	CFD	SHORT	3,047	45.5318 GBP
5p ordinary	CFD	SHORT	45,771	45.5318 GBP
5p ordinary	CFD	SHORT	9,872	45.5318 GBP
5p ordinary	CFD	SHORT	19,854	45.5318 GBP
5p ordinary	CFD	SHORT	17,042	45.5318 GBP
5p ordinary	CFD	SHORT	1,274	45.5318 GBP
5p ordinary	CFD	SHORT	18,718	45.5318 GBP
5p ordinary	CFD	SHORT	2,170	45.5318 GBP
5p ordinary	CFD	SHORT	18,196	45.5318 GBP
5p ordinary	CFD	SHORT	2,571	45.5318 GBP
5p ordinary	CFD	SHORT	2,686	45.5318 GBP
5p ordinary	CFD	SHORT	4,756	45.5318 GBP
5p ordinary	CFD	SHORT	10,871	45.5318 GBP
5p ordinary	CFD	SHORT	3,265	45.5318 GBP
5p ordinary	CFD	SHORT	11,969	45.5318 GBP
5p ordinary	CFD	SHORT	74	45.6674 GBP
5p ordinary	CFD	SHORT	247	45.6674 GBP
5p ordinary	CFD	SHORT	59	45.6674 GBP
5p ordinary	CFD	SHORT	414	45.6674 GBP
5p ordinary	CFD	SHORT	108	45.6674 GBP
5p ordinary	CFD	SHORT	426	45.6674 GBP
5p ordinary	CFD	SHORT	50	45.6674 GBP
5p ordinary	CFD	SHORT	30	45.6674 GBP
5p ordinary	CFD	SHORT	272	45.6674 GBP
5p ordinary	CFD	SHORT	452	45.6674 GBP
5p ordinary	CFD	SHORT	388	45.6674 GBP
5p ordinary	CFD	SHORT	225	45.6674 GBP
5p ordinary	CFD	SHORT	1,042	45.6674 GBP
5p ordinary	CFD	SHORT	69	45.6674 GBP
5p ordinary	CFD	SHORT	61	45.6674 GBP
5p ordinary	CFD	SHORT	4,006	45.7950 GBP
5p ordinary	CFD	SHORT	60,165	45.7950 GBP
5p ordinary	CFD	SHORT	12,978	45.7950 GBP
5p ordinary	CFD	SHORT	26,097	45.7950 GBP
5p ordinary	CFD	SHORT	22,403	45.7950 GBP
5p ordinary	CFD	SHORT	15,732	45.7950 GBP
5p ordinary	CFD	SHORT	1,677	45.7950 GBP
5p ordinary	CFD	SHORT	2,854	45.7950 GBP
5p ordinary	CFD	SHORT	24,605	45.7950 GBP
5p ordinary	CFD	SHORT	6,252	45.7950 GBP
5p ordinary	CFD	SHORT	23,920	45.7950 GBP
5p ordinary	CFD	SHORT	3,380	45.7950 GBP
5p ordinary	CFD	SHORT	3,531	45.7950 GBP
5p ordinary	CFD	SHORT	4,291	45.7950 GBP
5p ordinary	CFD	SHORT	14,290	45.7950 GBP
5p ordinary	CFD	SHORT	1,503	45.2115 GBP
5p ordinary	CFD	SHORT	8,164	46.2128 GBP
5p ordinary	CFD	SHORT	1,177	57.0155 USD
5p ordinary	CFD	SHORT	28,823	57.0155 USD
5p ordinary	CFD	SHORT	1,095	57.1387 USD
5p ordinary	CFD	SHORT	1,642	57.4384 USD

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security	Product description e.g. call option	Writing, purchasing, selling, varying etc.	Number of securities to which option relates	Exercise price per unit	Typee.g. American, European etc.	Expiry date	Option money paid/ received per unit
ADR	CALL	PURCHASE	6,000	180.0000	A	18/04/2019	4.3000 USD

(ii) Exercise

Class of relevant security	Product description e.g. call option	Exercising/ exercised against	Number of securities	Exercise price per unit
N/A	N/A	N/A	N/A	N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security	Nature of dealing e.g. subscription, conversion	Details	Price per unit (if applicable)
N/A	N/A	N/A	N/A

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer: Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

NONE

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to: (i) the voting rights of any relevant securities under any option; or (ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced: If there are no such agreements, arrangements or understandings, state 'none'

NONE

Date of disclosure:	19 DECEMBER 2018
Contact name:	Craig Horsley
Telephone number:	[phone]

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on [phone].

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.