Shire : Form 8.5 (EPT/RI) - Replacement of Shire plc

AMENDMENT Section (2b)

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:	Morgan Stanley Capital Services LLC
(b) Name of offeror/offeree in relation to whose relevant securities this form relates: Use a separate form for each offeror/offeree	Shire plc
(c) Name of the party to the offer with which exempt principal trader is connected:	Shire plc
(d) Date dealing undertaken:	19 DECEMBER 2018
(e) In addition to the company in 1(b) above, is the exempt principal trader making disclosures in respect of any other party to this offer? If it is a cash offer or possible cash offer, state 'N/A'	Yes - Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security	Purchases/ sales	Total number of securities	Highest price per unit paid/received	Lowest price per unit paid/received
ADR	PURCHASES	456	168.8200 USD	168.1800 USD
ADR	SALES	26,430	168.9300 USD	167.5300 USD

(b) Cash-settled derivative transactions

Class of relevant security	Product description e.g. CFD	Nature of dealing e.g. opening/closing a long/short position, increasing/reducing a long/short position	Number of reference securities	Price per unit
ADR	CFD	LONG	10,300	168.3523 USD
ADR	CFD	LONG	10,300	168.3523 USD
ADR	CFD	SHORT	100	168.2400 USD
ADR	CFD	SHORT	100	168.2400 USD
ADR	CFD	SHORT	300	168.3244 USD
ADR	CFD	SHORT	310	168.3256 USD
ADR	CFD	SHORT	10	168.3600 USD
5p ordinary	CFD	LONG	363	43.8206 GBP
5p ordinary	CFD	LONG	308	43.8206 GBP
5p ordinary	CFD	LONG	5,596	43.8206 GBP
5p ordinary	CFD	LONG	3,870	44.3422 GBP
5p ordinary	CFD	SHORT	490,375	43.7100 GBP
5p ordinary	CFD	SHORT	61	44.0132 GBP
5p ordinary	CFD	SHORT	296	44.0132 GBP
5p ordinary	CFD	SHORT	29,000	44.2554 GBP
5p ordinary	CFD	SHORT	3,265	44.3177 GBP
5p ordinary	CFD	SHORT	18,369	44.3177 GBP
5p ordinary	CFD	SHORT	32,418	44.3177 GBP
5p ordinary	CFD	SHORT	5,763	44.3177 GBP
5p ordinary	CFD	SHORT	20,239	44.3177 GBP
5p ordinary	CFD	SHORT	35,719	44.3177 GBP
5p ordinary	CFD	SHORT	3,644	44.3177 GBP
5p ordinary	CFD	SHORT	6,432	44.3177 GBP
5p ordinary	CFD	SHORT	55,099	44.3177 GBP
5p ordinary	CFD	SHORT	31,221	44.3177 GBP
5p ordinary	CFD	SHORT	2,185	44.3177 GBP
5p ordinary	CFD	SHORT	3,857	44.3177 GBP
5p ordinary	CFD	SHORT	3,249	44.3177 GBP
5p ordinary	CFD	SHORT	4,712	44.3177 GBP
5p ordinary	CFD	SHORT	2,670	44.3177 GBP
5p ordinary	CFD	SHORT	5,733	44.3177 GBP
5p ordinary	CFD	SHORT	26,031	44.3177 GBP
5p ordinary	CFD	SHORT	14,750	44.3177 GBP
5p ordinary	CFD	SHORT	5,238	44.3177 GBP
5p ordinary	CFD	SHORT	9,245	44.3177 GBP
5p ordinary	CFD	SHORT	79,409	44.3177 GBP
5p ordinary	CFD	SHORT	3,012	44.3177 GBP
5p ordinary	CFD	SHORT	140,138	44.3177 GBP
5p ordinary	CFD	SHORT	5,316	44.3177 GBP
5p ordinary	CFD	SHORT	14,528	44.3177 GBP
5p ordinary	CFD	SHORT	25,640	44.3177 GBP
5p ordinary	CFD	SHORT	50,766	44.3177 GBP
5p ordinary	CFD	SHORT	21,057	44.3177 GBP
5p ordinary	CFD	SHORT	28,766	44.3177 GBP
5p ordinary	CFD	SHORT	11,932	44.3177 GBP
5p ordinary	CFD	SHORT	75,000	44.3254 GBP
5p ordinary	CFD	SHORT	45	44.3271 GBP
5p ordinary	CFD	SHORT	25,000	44.3305 GBP
5p ordinary	CFD	SHORT	37,500	44.3336 GBP
5p ordinary	CFD	SHORT	37,500	44.3392 GBP
5p ordinary	CFD	SHORT	850	44.3770 GBP
5p ordinary	CFD	SHORT	2,324	44.3806 GBP
5p ordinary	CFD	SHORT	4,647	44.4675 GBP
5p ordinary	CFD	SHORT	26,141	44.4675 GBP
5p ordinary	CFD	SHORT	44,429	44.4675 GBP
5p ordinary	CFD	SHORT	5,186	44.4675 GBP
5p ordinary	CFD	SHORT	28,802	44.4675 GBP
5p ordinary	CFD	SHORT	3,110	44.4675 GBP
5p ordinary	CFD	SHORT	7,455	44.4675 GBP
5p ordinary	CFD	SHORT	20,990	44.4675 GBP
5p ordinary	CFD	SHORT	4,623	44.4675 GBP
5p ordinary	CFD	SHORT	3,800	44.4675 GBP
5p ordinary	CFD	SHORT	16,980	44.4675 GBP
5p ordinary	CFD	SHORT	40,935	44.4675 GBP
5p ordinary	CFD	SHORT	20,675	44.4675 GBP
5p ordinary	CFD	SHORT	4,286	44.4675 GBP
5p ordinary	CFD	SHORT	113,001	44.4675 GBP
5p ordinary	CFD	LONG	29	44.3150 GBP
5p ordinary	CFD	LONG	273	56.0463 USD
5p ordinary	CFD	SHORT	1,670	55.8617 USD
5p ordinary	CFD	SHORT	1,670	56.2711 USD

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security	Product description e.g. call option	Writing, purchasing, selling, varying etc.	Number of securities to which option relates	Exercise price per unit	Typee.g. American, European etc.	Expiry date	Option money paid/ received per unit
N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

(ii) Exercise

Class of relevant security	Product description e.g. call option	Exercising/ exercised against	Number of securities	Exercise price per unit
N/A	N/A	N/A	N/A	N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security	Nature of dealing e.g. subscription, conversion	Details	Price per unit (if applicable)
N/A	N/A	N/A	N/A

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer: Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

NONE

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to: (i) the voting rights of any relevant securities under any option; or (ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced: If there are no such agreements, arrangements or understandings, state 'none'

NONE

Date of disclosure:	21 DECEMBER 2018
Contact name:	Craig Horsley
Telephone number:	[phone]

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on [phone].

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.