Shire : Form 8.5 (EPT/RI) - SHIRE PLC

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:	Morgan Stanley & Co. International plc
(b) Name of offeror/offeree in relation to whose relevant securities this form relates: Use a separate form for each offeror/offeree	Shire plc
(c) Name of the party to the offer with which exempt principal trader is connected:	Shire plc
(d) Date dealing undertaken:	20 SEPTEMBER 2018
(e)Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?	Yes - Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security	Purchases/sales	Total number of securities	Highest price per unit paid/received	Lowest price per unit paid/received
5p ordinary	PURCHASES	526,826	45.5061 GBP	44.9150 GBP
5p ordinary	SALES	508,403	45.5000 GBP	44.9400 GBP
5p ordinary	PURCHASES	176,271	59.8947 USD	59.8775 USD
5p ordinary	SALES	2,664	59.7083 USD	59.5057 USD

(b) Cash-settled derivative transactions

Class of relevant security	Product description e.g. CFD	Nature of dealing e.g. opening/closing a long/short position, increasing/reducing a long/short position	Number of reference securities	Price per unit
ADR	CFD	LONG	9	179.4900 USD
ADR	CFD	LONG	320	179.4900 USD
ADR	CFD	LONG	255	179.4900 USD
ADR	CFD	LONG	416	179.9800 USD
ADR	CFD	LONG	23	179.9800 USD
ADR	CFD	LONG	214	179.9800 USD
ADR	CFD	LONG	213	179.9800 USD
ADR	CFD	LONG	23	179.9800 USD
ADR	CFD	SHORT	272	179.4900 USD
ADR	CFD	SHORT	273	179.4900 USD
ADR	CFD	SHORT	320	179.9800 USD
ADR	CFD	SHORT	255	179.9800 USD
ADR	CFD	SHORT	440	179.9800 USD
ADR	CFD	SHORT	14	179.9800 USD
ADR	CFD	SHORT	65	179.9800 USD
5p ordinary	CFD	LONG	10	45.0900 GBP
5p ordinary	CFD	LONG	21,429	45.1118 GBP
5p ordinary	CFD	LONG	2,378	45.1730 GBP
5p ordinary	CFD	LONG	2,826	45.1952 GBP
5p ordinary	CFD	LONG	2,354	45.2062 GBP
5p ordinary	CFD	LONG	4,434	45.2091 GBP
5p ordinary	CFD	LONG	5,235	45.2091 GBP
5p ordinary	CFD	LONG	67	45.2227 GBP
5p ordinary	CFD	LONG	33	45.2227 GBP
5p ordinary	CFD	LONG	706	45.2653 GBP
5p ordinary	CFD	LONG	11	45.2663 GBP
5p ordinary	CFD	LONG	1,538	45.3414 GBP
5p ordinary	CFD	LONG	77	45.4863 GBP
5p ordinary	CFD	SHORT	1,012	45.0103 GBP
5p ordinary	CFD	SHORT	240	45.0929 GBP
5p ordinary	CFD	SHORT	688	45.0929 GBP
5p ordinary	CFD	SHORT	307	45.0929 GBP
5p ordinary	CFD	SHORT	2	45.1100 GBP
5p ordinary	CFD	SHORT	4,093	45.1600 GBP
5p ordinary	CFD	SHORT	270	45.1688 GBP
5p ordinary	CFD	SHORT	1,596	45.1847 GBP
5p ordinary	CFD	SHORT	790	45.1847 GBP
5p ordinary	CFD	SHORT	216	45.2131 GBP
5p ordinary	CFD	SHORT	4,434	45.3101 GBP
5p ordinary	CFD	SHORT	2,302	45.3463 GBP
5p ordinary	CFD	SHORT	173	45.3901 GBP
5p ordinary	CFD	SHORT	969	45.5061 GBP
5p ordinary	CFD	LONG	73	45.3435 GBP
5p ordinary	CFD	SHORT	168,000	59.8357 USD
5p ordinary	CFD	SHORT	4,200	59.8947 USD
5p ordinary	CFD	SHORT	1,261	59.8947 USD
5p ordinary	CFD	SHORT	800	59.8947 USD
5p ordinary	CFD	SHORT	310	59.8947 USD
5p ordinary	CFD	SHORT	1,700	59.8947 USD

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security	Product description e.g. call option	Writing, purchasing, selling, varying etc.	Number of securities to which option relates	Exercise price per unit	Typee.g. American, European etc.	Expiry date	Option money paid/ received per unit
N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

(ii) Exercise

Class of relevant security	Product descriptione.g. call option	Number of securities	Exercise price per unit
N/A	N/A	N/A	N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security	Nature of dealinge.g. subscription, conversion	Details	Price per unit (if applicable)
N/A	N/A	N/A	N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer: If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to: (i) the voting rights of any relevant securities under any option; or (ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced: If there are no such agreements, arrangements or understandings, state 'none'

None

Date of disclosure:	21 SEPTEMBER 2018
Contact name:	Craig Horsley
Telephone number:	[phone]

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel [e-mail]. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on [phone].

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.