(Recasts following Raimondo's press conference in Shanghai, adds comment by Chinese foreign ministry in paragraphs 7-8)

SHANGHAI, Aug 30 (Reuters) - U.S. Commerce Secretary Gina Raimondo talked up American firms' desire to do business in China and her hopes for further engagement with Chinese officials on market access on Wednesday, after earlier comments over China being "uninvestible."

At a press conference in Shanghai, Raimondo said she had not expected any breakthroughs on issues affecting U.S. firms such as Intel, Micron, Boeing, Visa and Mastercard in her first meetings with Chinese officials, but did hope to "see some results" in the next few months as a result of her four-day visit to Beijing and Shanghai.

Raimondo said there was strong appetite among U.S. businesses to make the relationship work and that, while some actions of the Chinese government have been positive, the situation on the ground needed to match the rhetoric.

"There's business we can do and there's business to be done," she said. "U.S. businesses want to do business here but they need to have a predictable regulatory environment."

The commerce secretary is the latest Biden administration official to visit China in a bid to strengthen communications, particularly on economics and defense, amid concern that friction between the two superpower could spiral out of control.

Raimondo insists the U.S. does not want to decouple from China.

But on Tuesday she had told reporters on a high-speed train from Beijing to Shanghai that American companies had complained to her that China has become "uninvestible," pointing to fines, raids and other actions that have made it risky to do business in the world's second-largest economy.

Her comment on the difficulties U.S. businesses face has shone a harsh light on trade and investment flows between the geopolitical rivals.

"The essence of China-U.S. economic and trade relations is mutual benefit," said Wang Wenbin, a Chinese Foreign Ministry spokesperson, on Wednesday, citing Premier Li Qiang's remarks during his meeting with Raimondo on Tuesday.

"Politicizing and securitising economic and trade issues not only seriously affects the relationship and mutual trust between the two countries, it also harms the interests of their businesses and peoples," he added.

Companies have been at the center of a power struggle between the two countries for several years. China has criticized U.S. efforts to block China's access to advanced semiconductors through export controls.

Raimondo said export control dialog was to reduce misunderstandings.

We were able clarify at the first meeting that we are not targeting China," she said. "We're targeting actions and behavior that undermine US national security."

INVESTMENT FLOWS

The two biggest economies in the world used to be each other's largest trade partners, but Washington is now trading more with neighboring Canada and Mexico, while Beijing is trading more with Southeast Asia.

Global investors, who have been spooked by unpredictable crackdowns in China on sectors from e-commerce to education in recent years, have also been streaming out of Chinese assets lately.

Foreign net selling of 82.9 billion yuan ($11.4 billion) in Chinese stocks this month is a record outflow. Corporate investment is also going missing, with foreign direct investment (FDI) at its lowest since records began 25 years ago.

Michael Hart, president of the American Chamber of Commerce in China, said businesses had been "very clear" in making their concerns known to the Chinese government.

"Certain actions, including raids on companies and restricting data flows, are not conducive to attracting additional FDI," Hart said.

That sentiment was echoed by Jens Eskelund, president of the European Union Chamber of Commerce in China, who said "'uninvestible' is not a term we would use to describe China," instead describing it as "under-invested."

'A WHOLE NEW LEVEL OF CHALLENGE'

Raimondo said American firms were facing new challenges, among them "exorbitant fines without any explanation, revisions to the counterespionage law, which are unclear and sending shockwaves through the U.S. community; raids on businesses – a whole new level of challenge and we need that to be addressed."

Raimondo, in opening remarks at a meeting on Wednesday morning with Shanghai Communist Party Secretary Chen Jining, struck a positive tone, saying she wanted to discuss "concrete ways that we can work together to accomplish business goals and to bring about a more predictable business environment, a predictable regulatory environment and a level playing field for American businesses."

Chen said a stable relationship between China and the United States was crucial for the world, adding that Shanghai had the highest concentration of U.S. businesses in China.

On Wednesday afternoon, the commerce secretary visited Shanghai Disneyland and a Boeing facility in the city, touting two prominent American exports.

Disney has emphasized its Chinese links since Shanghai Disneyland - a joint venture with state-owned Shendi Group - opened in 2016.

Raimondo, who has said China was blocking tens of billions of dollars in deliveries of Boeing airplanes to Chinese airlines, on Tuesday said she raised the airlines' refusal to accept delivery of Boeing 737 MAX airplanes but won no commitments. (Reporting by David Shepardson in Shanghai; additional reporting by Nicoco Chan and Jason Xue in Shanghai and Joe Cash, Martin Quin Polland, Yew Lun Tian and Laurie Chen in Beijing; Editing by Sandra Maler, Robert Birsel and Alex Richardson)