You should read the following discussion and analysis of our financial condition
and results of operations together with our consolidated financial statements
and related notes appearing elsewhere in this Quarterly Report on Form 10-Q. The
following discussion contains forward-looking statements that involve risks
uncertainties and assumptions. Our actual results and the timing of certain
events could differ materially from those anticipated in these forward-looking
statements as a result of many factors. We discuss factors that we believe could
cause or contribute to these differences below and elsewhere in this Quarterly
Report on Form 10-Q, including those set forth under "Forward-looking
Statements" and "Risk Factors", as revised and supplemented by those risks
described from time to time in other reports which we file with the SEC.



OVERVIEW



We are a specialty pharmaceutical company committed to being the leader in
responsible pain management. Our first product, Xtampza ER, is an
abuse-deterrent, extended-release, oral formulation of oxycodone. In April 2016,
the FDA approved our NDA for Xtampza ER for the management of pain severe enough
to require daily, around-the-clock, long-term opioid treatment and for which
alternative treatment options are inadequate. In June 2016, we announced the
commercial launch of Xtampza ER.



Our product portfolio also includes Nucynta IR and Nucynta ER (collectively, the
"Nucynta Products"). In December 2017, we entered into a Commercialization
Agreement (the "Nucynta Commercialization Agreement") with Assertio
Therapeutics, Inc. ("Assertio"), pursuant to which we licensed the right to
commercialize the Nucynta Products in the United States. Nucynta ER is an
extended-release formulation of tapentadol that is indicated for the management
of pain severe enough to require daily, around-the-clock, long-term opioid
treatment, including neuropathic pain associated with diabetic peripheral
neuropathy in adults, and for which alternate treatment options are inadequate.
Nucynta IR is an immediate-release formulation of tapentadol that is indicated
for the management of acute adult pain severe enough to require an opioid
analgesic and for which alternative treatments are inadequate.



We began shipping and recognizing product sales on the Nucynta Products on
January 9, 2018 and began marketing the Nucynta Products in February 2018. On
February 6, 2020, we entered into an Asset Purchase Agreement with Assertio (the
"Nucynta Purchase Agreement"), pursuant to which we agreed to acquire from
Assertio certain assets related to the Nucynta Products (the "Nucynta
Acquisition"), including the license from Grünenthal GmbH ("Grünenthal"), for an
aggregate purchase price of $375.0 million. On February 13, 2020, we closed the
Nucynta Acquisition in accordance with the Nucynta Purchase Agreement. Upon
closing, the Nucynta Commercialization Agreement was effectively terminated and
our royalty payment obligations to Assertio thereunder ceased. Following the
closing, we pay royalties directly to Grünenthal at a rate of 14% of net sales
of the Nucynta Products and no longer pay royalties to Assertio.



Outlook



We expect to continue to incur significant commercialization expenses related to
marketing, manufacturing, distribution, selling and reimbursement activities. We
are promoting Xtampza ER to approximately 11,000 health care professionals who
write approximately 65% of the branded extended-release oral opioid
prescriptions in the United States with a sales team of approximately 150 sales
representatives and managers. We are promoting the Nucynta Products to the same
health care professionals to whom we promote Xtampza ER, leveraging our existing
sales organization.



Net income for the three and nine months ended September 30, 2020 was $11.3
million and $19.8 million, respectively. In every annual reporting period since
inception, we have incurred net losses. As of September 30, 2020, we had an
accumulated deficit of $340.1 million. Substantially all of our prior net losses
resulted from costs incurred in connection with selling, general and
administrative costs associated with our operations and research and development
programs. We have historically paid royalties to Assertio on all revenues from
the sale of Nucynta Products based on certain net sales thresholds, which ceased
upon closing of the Nucynta Acquisition. Our net income (loss) may fluctuate
significantly from quarter to quarter and year to year.

We believe that our cash and cash equivalents at September 30, 2020, together
with expected cash inflows from the commercialization of our products, will
enable us to fund our operating expenses, debt service and capital expenditure
requirements under our current business plan for the foreseeable future.

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In December 2019, a novel strain of coronavirus began infecting people in China;
since then, the disease caused by that virus, COVID-19, has sickened millions of
people across the world and in March 2020, the World Health Organization
declared COVID-19 a pandemic. The pandemic has severely impacted global economic
activity, and many countries and many states in the United States have reacted
to the outbreak by instituting quarantines, mandating business and school
closures and restricting travel. As of the date of the filing of this Quarterly
Report on Form 10-Q, we expect the COVID-19 pandemic and actions taken to
contain it to impact our revenue (due to fewer new patients beginning therapy
with our products and adverse impact on our ability to promote our products due
to closure or limited operations of many physicians' offices) and have decreased
certain operating expenses, including travel, marketing and expenses associated
with participation in congresses that have been postponed. We believe that the
disruptions caused by COVID-19 will continue and there remains substantial
uncertainty as to when such disruptions will cease (or ease).



CRITICAL ACCOUNTING POLICIES AND SIGNIFICANT JUDGMENTS AND ESTIMATES


We believe that several accounting policies are important to understanding our
historical and future performance. We refer to these policies as "critical"
because these specific areas generally require us to make judgments and
estimates about matters that are uncertain at the time we make the estimate, and
different estimates-which also would have been reasonable-could have been used,
which would have resulted in different financial results.



The critical accounting policies we identified in our Annual Report on Form 10-K
for the fiscal year ended December 31, 2019 ("Annual Report"), relate to revenue
recognition and impairment of intangible assets. Estimates include revenue
recognition, including the estimates of product returns, units prescribed,
discounts and allowances related to commercial sales of our products, estimates
utilized in the valuation of inventory, estimates of useful lives with respect
to intangible assets, accounting for stock-based compensation, contingencies,
intangible assets, and tax valuation reserves. We base our estimates and
assumptions on historical experience when available and on various factors that
we believe are reasonable under the circumstances, the results of which form the
basis for making judgments about the carrying value of assets and liabilities
that are not readily apparent from other sources. We evaluate our estimates and
assumptions on an ongoing basis. Actual results may differ from these estimates
under different assumptions or conditions. It is important that the discussion
of our operating results that follows be read in conjunction with the critical
accounting policies disclosed in our Annual Report.



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RESULTS OF OPERATIONS

(in thousands)




                                          Three months ended
                                            September 30,              Nine months ended September 30,
                                         2020            2019             2020                  2019

                                            (in thousands)                       (in thousands)
Product revenues, net                 $   79,176      $   72,942    $        233,745      $        222,498
Cost of product revenues
Cost of product revenues (excluding
intangible asset amortization)            14,188          43,066              54,316               133,508
Intangible asset amortization             16,795           3,688              43,885                11,064
Total cost of products revenues           30,983          46,754              98,201               144,572
Gross profit                              48,193          26,188             135,544                77,926
Operating expenses
Research and development                   2,141           2,491               7,300                 7,942
Selling, general and administrative       26,426          30,072              87,008                91,359
Total operating expenses                  28,567          32,563              94,308                99,301
Income (loss) from operations             19,626         (6,375)           

  41,236              (21,375)
Interest expense                         (8,063)           (228)            (21,145)                 (698)
Interest income                                3             494                 229                 1,552

Income (loss) before income taxes         11,566         (6,109)              20,320              (20,521)
Provision for income taxes                   280               -           

     526                     -
Net income (loss)                     $   11,286      $  (6,109)    $         19,794      $       (20,521)

Comparison of the three months ended September 30, 2020 and September 30, 2019





Product revenues, net were $79.2 million for the three months ended
September 30, 2020 (the "2020 Quarter"), compared to $72.9 million for the three
months ended September 30, 2019 (the "2019 Quarter"). The $6.3 million increase
was related to an increase in revenue for Xtampza ER of $5.6 million combined
with an increase in revenue for the Nucynta Products of $588,000. For the 2020
Quarter, Xtampza ER product revenues, net were $32.1 million, compared to $26.5
million for the 2019 Quarter. The increase in revenue for Xtampza ER was
primarily related to an increase in sales volume due to increased demand and an
increase in price. For the 2020 Quarter, Nucynta IR and ER product revenues, net
were $30.0 million and $17.1 million, respectively, compared to $28.1 million
and $18.3 million, respectively, for the 2019 Quarter. The increase in revenue
for the Nucynta Products was primarily related to an increase in price,
partially offset by lower sales volume.



Cost of product revenues (excluding intangible asset amortization) was $14.2
million for the 2020 Quarter, compared to $43.1 million for the 2019
Quarter. The $28.9 million decrease was primarily related to a decrease in
royalty expense for the Nucynta Products. In the 2019 Quarter, we recognized
$30.2 million in sales-based royalty expense due to Assertio under the terms of
the Nucynta Commercialization Agreement. Our sales-based royalty obligations to
Assertio ceased upon closing of the Nucynta Acquisition on February 13, 2020.



Intangible asset amortization was $16.8 million for the 2020 Quarter, compared
to $3.7 million for the 2019 Quarter. The $13.1 million increase was primarily
related to the Nucynta Acquisition, in which $367.1 million of consideration was
allocated to the existing intangible asset as incremental cost in 2020. The
intangible asset is being amortized on a straight-line basis over its estimated
useful life of approximately six years.



Research and development expenses were $2.1 million for the 2020 Quarter, compared to $2.5 million for the 2019 Quarter. The $350,000 decrease was primarily related to a decrease in trial related costs.

Selling, general and administrative expenses were $26.4 million for the 2020 Quarter, compared to $30.1 million for the 2019 Quarter. The $3.7 million decrease was primarily related to:

? a decrease in travel, trainings, conferences and meetings of $1.7 million

primarily due to the restrictions imposed in response to the COVID-19 outbreak;




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a decrease in sales, marketing, and consulting costs of $1.5 million, primarily

? due to lower costs incurred in the 2020 Quarter to support the ongoing

commercialization of our products; and

? a decrease in fees, permits and other regulatory costs, including

post-marketing requirements, of $457,000.

Interest expense was $8.1 million for the 2020 Quarter, compared to $228,000 in the 2019 Quarter. The $7.9 million increase was primarily due to interest expense recognized in the 2020 Quarter associated with the term notes and convertible notes issued in connection with the Nucynta Acquisition.





Interest income was $3,000 for the 2020 Quarter, compared to $494,000 in the
2019 Quarter. The $491,000 decrease was primarily due to lower interest rates in
the 2020 Quarter.


Comparison of the nine months ended September 30, 2020 and September 30, 2019





Product revenues, net were $233.7 million for the nine months ended
September 30, 2020 (the "2020 Period"), compared to $222.5 million for the nine
months ended September 30, 2019 (the "2019 Period"). The $11.2 million increase
was related to an increase in revenue for Xtampza ER of $19.6 million, offset by
a decrease in revenue for the Nucynta Products of $8.4 million. For the 2020
Period, Xtampza ER product revenues, net were $97.2 million, compared to $77.6
million for the 2019 Period. The increase in revenue for Xtampza ER was
primarily related to an increase in sales volume due to increased demand and an
increase in price. For the 2020 Period, Nucynta IR and ER product revenues, net
were $87.0 million and $49.5 million, respectively, compared to $87.5 million
and $57.4 million, respectively, for the 2019 Period. The decrease in revenue
for the Nucynta Products was primarily related to lower sales volume, partially
offset by an increase in price.



Cost of product revenues (excluding intangible asset amortization) was $54.3
million for the 2020 Period, compared to $133.5 million for the 2019 Period. The
$79.2 million decrease was primarily related to a decrease in royalty expense
for the Nucynta Products. In the 2019 Period, we recognized $94.2 million in
sales-based royalty expense due to Assertio under the terms of the Nucynta
Commercialization Agreement, compared to $19.1 million in the 2020 Period. The
$19.1 million represented sales-based royalties due to Assertio prior to the
closing of the Nucynta Acquisition on February 13, 2020. Our sales-based royalty
obligations due to Assertio ceased upon closing the Nucynta Acquisition.



Intangible asset amortization was $43.9 million for the 2020 Period, compared to
$11.1 million for the 2019 Period. The $32.8 million increase was primarily
related to the Nucynta Acquisition, in which $367.1 million of consideration was
allocated to the existing intangible asset as incremental cost. The intangible
asset is being amortized on a straight-line basis over its estimated useful life
of approximately six years.



Research and development expenses were $7.3 million for the 2020 Period, compared to $7.9 million for the 2019 Period. The $642,000 decrease was primarily related to a decrease in trial related costs.







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Selling, general and administrative expenses were $87.0 million for the 2020
Period, compared to $91.4 million for the 2019 Period. The $4.4 million decrease
was primarily related to:

? a decrease in audit, legal, and other professional fees of $3.7 million,

primarily due to lower litigation costs;

a decrease in sales, marketing, and consulting costs of $3.2 million, primarily

? due to lower costs incurred in the 2020 Period to support the ongoing

commercialization of our products;

a decrease in travel, trainings, conferences, and meetings of $3.1 million,

? primarily due to the restrictions imposed in response to the COVID-19 outbreak;

partially offset by

? an increase in product taxes and fees of $2.2 million, primarily due to certain

states recently enacting excise taxes on the sale of opioids;

an increase in salaries, wages and benefits of $1.3 million, primarily due to

? stock-based compensation expense, wage increases and incentive compensation

expense;

? an increase in insurance of $692,000, primarily due to higher premiums;

? an increase in fees, permits and other regulatory costs, including

post-marketing requirements, of $603,000; and

? an increase in systems, licenses and support of $514,000.

Interest expense was $21.1 million for the 2020 Period, compared to $698,000 in the 2019 Period. The $20.4 million increase was primarily due to interest expense recognized in the 2020 Period associated with the term notes and convertible notes issued in connection with the Nucynta Acquisition.


Interest income was $229,000 for the 2020 Period, compared to $1.6 million in
the 2019 Period. The $1.3 million decrease was primarily due to lower interest
rates in the 2020 Period.



Provision for income taxes was $526,000 for the 2020 Period, compared to none in
the 2019 Period. The $526,000 increase was primarily due state income tax
expense as, in the 2020 Quarter, certain states enacted changes in tax laws that
prevent us from using our state-level NOLs to offset taxable income. In
addition, we continue to generate more taxable income from sales of our products
in states in which we do not have sufficient state-level NOLs to fully offset
state taxable income. We did not record income tax expense in the 2019 Period
due to the utilization of federal and state NOLs carried forward to offset
taxable income.



LIQUIDITY AND CAPITAL RESOURCES





Sources of Liquidity


As of September 30, 2020, we had $165.4 million in cash and cash equivalents. We intend to rely on our existing cash and cash equivalents together with cash flows from the commercialization of our products as our primary source of liquidity.





Although it is difficult to predict future liquidity requirements, we believe
that our cash and cash equivalents at September 30, 2020, together with expected
cash inflows from the commercialization of our products, will enable us to fund
our operating expenses, debt service and capital expenditure requirements under
our current business plan for the foreseeable future.



Borrowing Arrangements and Equity Offerings

The following transactions represent the material changes in borrowing arrangements and equity offerings that were previously disclosed in our most recent Annual Report.





Pharmakon Term Notes



On February 6, 2020, in connection with the execution of the Nucynta Purchase
Agreement, we, together with our subsidiary, Collegium Securities Corporation,
entered into the Loan Agreement with BioPharma Credit PLC, as collateral agent
and lender; and BioPharma Credit Investments V (Master) LP, as lender. The Loan
Agreement provides for a $200.0 million secured term loan (the "term notes"),
the proceeds of which were used to finance a portion of the purchase price paid
pursuant to the Nucynta Purchase Agreement.



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The term notes will mature on the calendar quarter end immediately following the
48-month anniversary of the closing of the Nucynta Acquisition, and is
guaranteed by our material domestic subsidiaries and is also secured by
substantially all of our material domestic assets. The term notes will bear
interest at a rate based upon LIBOR (subject to a LIBOR floor of 2.0%), plus a
margin of 7.5% per annum. We are required to repay the term notes by making
equal quarterly payments.



The Loan Agreement contains certain covenants and obligations of the parties,
including, without limitation, covenants that require us to maintain $200.0
million in annual net sales and covenants that limit our ability to incur
additional indebtedness or liens, make acquisitions or other investments or
dispose of assets outside the ordinary course of business. Failure to comply
with these covenants would constitute an event of default under the Loan
Agreement, notwithstanding our ability to meet its debt service obligations. The
Loan Agreement also includes various customary remedies for the lenders
following an event of default, including the acceleration of repayment of
outstanding amounts under the Loan Agreement and execution upon the collateral
securing obligations under the Loan Agreement.



2026 Convertible Notes



On February 13, 2020, in connection with the execution of the Nucynta Purchase
Agreement, we issued 2.625% convertible senior notes due 2026 (the "convertible
notes"), in the aggregate principal amount of $143.8 million, in a public
offering registered under the Securities Act of 1933, as amended. The proceeds
were used to finance a portion of the purchase price paid pursuant to the
Nucynta Purchase Agreement.



The convertible notes are senior, unsecured obligations and will accrue interest
at a rate of 2.625% per annum, payable semi-annually in arrears on February 15
and August 15 of each year, beginning on August 15, 2020. The notes will mature
on February 15, 2026, unless earlier repurchased, redeemed or converted. Before
August 15, 2025, noteholders will have the right to convert their notes only
upon the occurrence of certain events. From and after August 15, 2025,
noteholders may convert their notes at any time at their election until the
close of business on the scheduled trading day immediately before the maturity
date. We will settle conversions by paying or delivering, as applicable, cash,
shares of our common stock or a combination of cash and shares of our common
stock, at our election. The initial conversion rate is 34.2618 shares of common
stock per $1,000 principal amount of notes, which represents an initial
conversion price of approximately $29.19 per share of common stock. The
conversion rate and conversion price will be subject to adjustment upon the
occurrence of certain events.



Silicon Valley Bank Term Loan Facility





From August 2012 until January 2020, we maintained a term loan facility with
Silicon Valley Bank, which was amended in connection with, and as a condition
to, consummation of the transactions contemplated by the Nucynta
Commercialization Agreement. Under the amended term loan, we had a term loan
facility in an amount of $11.5 million, which replaced our previously existing
term loan facility. The proceeds were used to finance certain payment
obligations under the Nucynta Commercialization Agreement and to repay the
balance of the previously existing term loan. In January 2020, in anticipation
of consummation of the Nucynta Acquisition and related financing activities, we
repaid all of our outstanding indebtedness under the amended term loan.



Cash Flows




                                                         Nine months ended September 30,
                                                             2020               2019

Net cash provided by operating activities                $     71,365      $        12,127
Net cash used in investing activities                       (372,291)      

(5,549)


Net cash provided by financing activities                     298,877                  627
Net (decrease) increase in cash, cash equivalents and
restricted cash                                          $    (2,049)      $         7,205




Operating activities.  Cash provided by operating activities was $71.4 million
in the 2020 Period, compared to cash provided by operating activities of $12.1
million in 2019 Period. The $59.3 million increase in cash provided by operating
activities was primarily due to higher net income and non-cash adjustments
related to the Nucynta Acquisition,

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which resulted in higher intangible asset amortization and higher non-cash interest expense from the term notes and convertible notes. These increases were partially offset by decreases in working capital accounts.


Investing activities.  Cash used in investing activities was $372.3 million in
the 2020 Period, compared to cash used in investing activities of $5.5 million
in the 2019 Period. The $366.8 million increase in cash used in investing
activities was primarily related to the Nucynta Acquisition. The remaining
change is primarily related to the timing of purchases of property, plant, and
equipment primarily for the dedicated production suite at our contract
manufacturing organization.



Financing activities.  Cash provided by financing activities was $298.9 million
for the 2020 Period, compared to cash provided by financing activities of
$627,000 in the 2019 Period. The $298.3 million increase in cash provided by
financing activities was primarily related to net proceeds from the term notes
of $192.1 million and issuance of the convertible notes of $138.3 million, both
of which were issued in the 2020 Period. This increase was partially offset by
term note repayments of $25.0 million and the SVB term loan repayment of $11.5
million. The remaining change is primarily related to changes in proceeds from
the issuance of shares under our employee stock purchase plan and proceeds from
exercises of stock options, offset by payments made for employee restricted

stock tax withholdings.



Funding Requirements



We believe that our cash and cash equivalents at September 30, 2020 together
with expected cash inflows from the commercialization of our products, will
enable us to fund our operating expenses, debt service and capital expenditure
requirements under our current business plan for the foreseeable future.
However, we are subject to all the risks common to the commercialization and
development of new pharmaceutical products, and we may encounter unforeseen
expenses, difficulties, complications, delays and other unknown factors that may
adversely affect our business.



Certain economic or strategic considerations may cause us to seek additional
cash through private or public debt or equity offerings. Such funds may not be
available when needed, or, we may not be able to obtain funding on favorable
terms, or at all. The continued spread of COVID-19 has led to severe disruption
and volatility in the global capital markets, which could increase our cost of
capital and adversely affect our ability to access the capital markets. If we
are unable to raise additional capital in sufficient amounts or on terms
acceptable to us, we may have to significantly delay, scale back or discontinue
the development or commercialization of one or more of our products. If we raise
additional funds through the issuance of additional debt or equity securities,
it could result in dilution to our existing shareholders, increased fixed
payment obligations and the existence of securities with rights that may be
senior to those of our common stock. If we incur indebtedness, we could become
subject to covenants that would restrict our operations and potentially impair
our competitiveness, such as limitations on our ability to incur additional
debt, limitations on our ability to acquire, sell or license intellectual
property rights and other operating restrictions that could adversely impact our
ability to conduct our business. Any of these events could significantly harm
our business, financial condition and prospects.



Our forecast that our financial resources will be adequate to support our
operations is a forward-looking statement and involves risks and uncertainties,
and actual results could vary as a result of a number of factors. We have based
this estimate on assumptions that may prove to be wrong, and we could utilize
our available capital resources sooner than we currently expect. The amount and
timing of future funding requirements, both near- and long-term, will depend on
many factors, including:


? the generation of reasonable levels of revenue from products sales and the

impact of the COVID-19 pandemic on our business and results of operations;

? the cost of growing and maintaining sales, marketing and distribution

capabilities for our products;

the cost of patent infringement litigation, including our litigation with

? Purdue, relating to Xtampza ER and the Nucynta Products, which may be expensive

to defend;

? the cost of litigation related to opioid marketing and distribution practices;

? the timing and costs associated with manufacturing our products, for commercial

sale and clinical trials; and

? the effect of competing technological and market developments






If we cannot capitalize on our business opportunities because we lack sufficient
capital, our business, financial condition and results of operations could be
materially adversely affected.



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ADDITIONAL INFORMATION



To supplement our financial results presented on a GAAP basis, we have included
information about non-GAAP adjusted income and adjusted EBITDA. We use these
non-GAAP financial measures to understand, manage and evaluate the Company as we
believe they represent the performance of our core business. Because these
non-GAAP financial measures are important internal measures for the Company, we
believe that the presentation of these non-GAAP financial measures provides
analysts, investors, lenders and other third parties insight into management's
view and assessment of the Company's ongoing operating performance. In addition,
we believe that the presentation of these non-GAAP financial measures, when
viewed with our results under GAAP and the accompanying reconciliation, provide
supplementary information that may be useful to analysts, investors, lenders,
and other third parties in assessing the Company's performance and results from
period to period. We report these non-GAAP financial measures to portray the
results of our major operations prior to considering certain income statement
elements. These non-GAAP financial measures should be considered in addition to,
and not as a substitute for, or superior to, net income or other financial
measures calculated in accordance with GAAP.



Non-GAAP Adjusted Income



Non-GAAP adjusted income is not based on any standardized methodology prescribed
by GAAP and represents GAAP net income (loss) adjusted to exclude stock-based
compensation expense, amortization expense, non-cash interest expense, certain
royalty costs recognized in connection with the Nucynta Commercialization
Agreement and the provision for income taxes. Non-GAAP adjusted income as used
by us may be calculated differently from, and therefore may not be comparable
to, similarly titled measures used by other companies.




                                      Three months ended       Nine months ended
                                        September 30,            September 30,
                                       2020        2019        2020         2019
GAAP net income (loss)              $   11,286   $ (6,109)   $  19,794   $ (20,521)
Non-GAAP adjustments:

Stock-based compensation expense(1)      5,165       4,137      15,700     

12,562

Intangible asset amortization(2) 16,795 3,688 43,885

11,064


Non-cash interest expense(3)             2,567           -       6,427     

-


Nucynta royalty adjustment (4)               -           -      14,216     

-


Provision for income taxes (5)             280           -         526     

-

Total non-GAAP adjustments $ 24,807 $ 7,825 $ 80,754 $


 23,626
Non-GAAP adjusted income            $   36,093   $   1,716   $ 100,548   $    3,105





(1)
Represents stock-based compensation expense associated with our stock option,
restricted stock unit and performance stock unit grants and our employee share
purchase plan.
(2)
Represents amortization expense from the Nucynta Intangible Asset.
(3)
Represents non-cash interest expense recognized related to the accretion of debt
discount and amortization of debt issuance costs.
(4)
Represents non-recurring adjustment for royalty expense recognized in 2020 prior
to the closing of the Nucynta Asset Purchase Agreement in February 2020. The
royalty expense was included as a reduction to the base purchase price for the
Nucynta Asset Purchase Agreement and, upon closing, the Company was discharged
of any unpaid royalties due to Assertio.
(5)
Represents current provision for estimated income taxes.


Adjusted EBITDA



Adjusted EBITDA represents GAAP net income (loss) adjusted to exclude interest
expense, interest income, income tax expense, depreciation, amortization, and
stock-based compensation. Adjusted EBITDA as used by us may be calculated
differently from, and therefore may not be comparable to, similarly titled
measures used by other companies.



There are several limitations related to the use of adjusted EBITDA rather than net income (loss), which is the nearest GAAP equivalent, such as:

adjusted EBITDA excludes depreciation and amortization, and, although these are

? non-cash expenses, the assets being depreciated or amortized may have to be


   replaced in the future, the cash requirements for which are not reflected in
   adjusted EBITDA;


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we exclude stock-based compensation expense from adjusted EBITDA although (a)

it has been, and will continue to be for the foreseeable future, a significant

? recurring expense for our business and an important part of our compensation

strategy and (b) if we did not pay out a portion of our compensation in the

form of stock-based compensation, the cash salary expense included in operating

expenses would be higher, which would affect our cash position;

? adjusted EBITDA does not reflect changes in, or cash requirements for, working

capital needs;

? adjusted EBITDA does not reflect provision for income taxes or the cash

requirements to pay taxes; and

? adjusted EBITDA does not reflect historical cash expenditures or future

requirements for capital expenditures or contractual commitments.







                                   Three months ended       Nine months ended
                                     September 30,            September 30,
                                    2020        2019        2020         2019
GAAP net income (loss)           $   11,286   $ (6,109)   $  19,794   $ (20,521)
Adjustments:
Interest expense                      8,063         228      21,145          698
Interest income                         (3)       (494)       (229)      (1,552)
Provision for income taxes              280           -         526            -
Depreciation                            195         180         589          535
Amortization                         16,795       3,688      43,885       11,064
Stock-based compensation expense      5,165       4,137      15,700       12,562
Total adjustments                $   30,495   $   7,739   $  81,616   $   23,307
Adjusted EBITDA                  $   41,781   $   1,630   $ 101,410   $    2,786





                                        First Quarter    Second Quarter     Third Quarter
                                            2020              2020              2020
GAAP net income                        $           450   $         8,058   $        11,286
Adjustments:
Interest expense                                 4,823             8,259             8,063
Interest income                                  (212)              (14)               (3)
Provision for income taxes                           -               246               280
Depreciation                                       198               196               195
Amortization                                    10,295            16,795            16,795

Stock-based compensation expense                 4,951             5,584             5,165
Total adjustments                      $        20,055   $        31,066   $        30,495
Adjusted EBITDA                        $        20,505   $        39,124   $        41,781





                                  First Quarter     Second Quarter     Third Quarter     Fourth Quarter
                                      2019               2019              2019               2019
GAAP net loss                    $       (9,700)   $        (4,712)   $       (6,109)   $        (2,201)
Adjustments:
Interest expense                             234                236               228                211
Interest income                            (526)              (532)             (494)              (383)
Provision for income taxes                     -                  -                 -                  -
Depreciation                                 184                171               180                196
Amortization                               3,688              3,688             3,688              3,688

Stock-based compensation expense           4,263              4,162        

    4,137              3,966
Total adjustments                $         7,843   $          7,725   $         7,739   $          7,678
Adjusted EBITDA                  $       (1,857)   $          3,013   $         1,630   $          5,477




CONTRACTUAL OBLIGATIONS



With the exception of the Loan Agreement with Pharmakon and issuance of
convertible notes previously discussed, there have been no material changes to
the contractual obligations and commitments described under Management's
Discussion and Analysis of Financial Condition and Results of Operations in

our
most recent Annual Report.

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OFF-BALANCE SHEET ARRANGEMENTS

We did not have during the periods presented any off­balance sheet arrangements, as defined under SEC rules.

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