On November 29, 2021, Exact Sciences Corporation (the Company) and Pfizer Inc. (Pfizer) entered into an amendment (the Amendment) to the Amended & Restated Cologuard ® Promotion Agreement effective October 6, 2020, by and between the Company and Pfizer (the Promotion Agreement). The Amendment provides that after November 30, 2021, Pfizer will no longer promote the Company's Cologuard colorectal cancer screening test (the Product) to health care providers. As reported on a Form 8-K filed by the Company on September 15, 2021, the Company recently hired approximately 400 former Pfizer sales representatives to promote the Product to health care providers.

The Amendment provides that the Company will pay Pfizer a total of $35,900,000 in three installments during the second, third, and fourth quarters of 2022. The Amendment eliminates the Company's obligation to pay Pfizer royalties or other fees except for certain media fees, advertising fees, and any detail fees owed to Pfizer for promoting the Product prior to November 30, 2021. Pursuant to the Promotion Agreement, as amended, Pfizer will continue to purchase certain advertising for the Product on behalf of the Company through the third quarter of 2022 and will provide support in transitioning responsibilities for purchasing such advertising to the Company.